Bill Gates CRISPR CAS9 Gene Editing And Jeffrey Epstein

Discussion in 'Viruses, Parasites, Fungus, Vaccines' started by Drareg, May 12, 2020.

  1. Drareg

    Drareg Member

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    Gates has a fascination with CRISPR CAS9 gene editing.
    The coming COVID vaccine will be CRISPR based is my guess, the slight of hand will be that it’s not technically a VACCINE, it’s editing of your own genome to produce antibodies, no foreign bodies like adjuvants are injected into you, YOU PRODUCE IT YOURSELF, ITS ALL FOR YOU DAMIEN ,ITS ALL FOR YOU!!
    This should all appeal to the overly narcissistic culture today, the marketing theme will spin it!

    I will continue adding to this thread mainly on how incoherent CRISPR CAS9 is relative to those in let’s say the "peaty" paradigm, those working with it don’t even think about the metabolic energy required to charge the genome for example.
    With regard to the Epstein link ,enough people are covering it so need to go in depth on that.


    He has been throwing money at this technology since it’s advancement in 2014-15,Boris Nikolic was Gates scientific advisor who is now the executor of jeffrey Epstein’s will, yes that Jeffrey Epstein the convicted child sex trafficker.
    This Boris -Who is Boris Nikolic? Epstein-named executor is former Bill Gates adviser

    Here’s a pic of Jeff ,bill and the mass genome editor crew-
    Bill Gates Met With Jeffrey Epstein Many Times, Despite His Past

    Bill Gates And 13 Other Investors Pour $120 Million Into Revolutionary Gene-Editing Startup

    "The lead investor is a newly created firm called bng0, a select group of family offices led by Boris Nikolic, who was previously a science advisor to Bill Gates. Both Editas and Gates’ office confirm that the Microsoft billionaire, who is the world’s richest man, is among the bng0 backers"

    Here is an article written by bill himself where his extolling the "virtues" of genome editing plants, mosquitos and humans -

    Gene Editing for Good
    "That includes CRISPR and other technologies for targeted gene editing. Over the next decade, gene editing could help humanity overcome some of the biggest and most persistent challenges in global health and development. The technology is making it much easier for scientists to discover better diagnostics, treatments, and other tools to fight diseases that still kill and disable millions of people every year, primarily the poor. It is also accelerating research that could help end extreme poverty by enabling millions of farmers in the developing world to grow crops and raise livestock that are more productive, more nutritious, and hardier. New technologies are often met with skepticism. But if the world is to continue the remarkable progress of the past few decades, it is vital that scientists, subject to safety and ethics guidelines, be encouraged to continue taking advantage of such promising tools as CRISPR"


    Here’s the wiki on CRSPR CAS9, keep in mind this is a big money industry so it’s a heavily edited page-CRISPR gene editing - Wikipedia

    Here is a puff piece written on using CRISPR for vaccines-
    Vaccines don't work against some viruses. CRISPR might fix that - STAT


    "That gave immunologist Justin Taylor of Fred Hutchinson Cancer Research Center an idea — skip the vaccine.

    Injecting antibodies directly has been shown to protect premature babies against respiratory syncytial virus, for instance. Antibodies against a number of HIV strains (“broadly neutralizing antibodies) control viral load in people with HIV, said Trevor Mundel, president of global health at the Bill and Melinda Gates Foundation. But the antibodies generally last only 21 days or so, and therefore have to be given again and again. So why not create a one-and-done therapy: use CRISPR-Cas9 to genetically reprogram B cells to produce, and keep producing, whatever antibody someone needs?"

    "There’s a long way to go before CRISPR’d B cells give anyone immunity to anything. For starters, the approach won’t replace traditional vaccines, if only for economic reasons. B cells would have to be CRISPR’d individually, patient by patient (donor B cells, CRISPR’d or otherwise, are rejected by the immune system). Vaccines, by comparison, are cheap. Taylor’s team has ideas about how to make universal-donor B cells, and Dan Wattendorf, director of Innovative Technology Solutions at the Gates Foundation, said “there are scientific opportunities” to tweak B cells so they’d be universal donors.

    If genetically altered B cells kept churning out antibodies, “it would be a one-shot” preventive or treatment, said the Gates Foundation’s Mundel.

    The biggest hurdle would be keeping viruses from outsmarting antibodies produced by CRISPR just as they do antibodies produced by vaccines, by tweaking their antigens just enough for the antibodies not to fit them anymore. But Taylor believes it’s possible to engineer B cells to defeat that antigenic drift, “even if you need five antibodies to cover that,” he said, something that is well within the capabilities of CRISPR"

    “We can see gene editing [to protect against viruses] becoming feasible,” said Wattendorf. “It’s a very interesting time.”

    It’s interesting that they are saying they need to Taylor B cells individually , this will require mass DNA sampling of everyone, many including myself have been naive enough to sign up to 23andme and give or DNA for free so we can be placed at the scene of murder real easy,blackmailed and the like.
    I guess we can donate our data to get or tailored CRISPR’d -DNA.
     
  2. OP
    Drareg

    Drareg Member

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    This study from December 2019 then is a little disconcerting -
    Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome

    Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome

    Since 2012, monthly cases of Middle East respiratory syndrome coronavirus (MERS-CoV) continue to cause severe respiratory disease that is fatal in ~35% of diagnosed individuals.
    The ongoing threat to global public health and the need for novel therapeutic countermeasures have driven the development of animal models that can reproducibly replicate the pathology associated with MERS-CoV in human infections.
    The inability of MERS-CoV to replicate in the respiratory tracts of mice, hamsters, and ferrets stymied initial attempts to generate small animal models.
    Identification of human dipeptidyl peptidase IV (hDPP4) as the receptor for MERS-CoV infection opened the door for genetic engineering of mice.
    Precise molecular engineering of mouse DPP4 (mDPP4) with clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 technology maintained inherent expression profiles, and limited MERS-CoV susceptibility to tissues that naturally express mDPP4, notably the lower respiratory tract wherein MERS-CoV elicits severe pulmonary pathology.
    Here, we describe the generation of the 288–330+/+ MERS-CoV mouse model in which mice were made susceptible to MERS-CoV by modifying two amino acids on mDPP4 (A288 and T330), and the use of adaptive evolution to generate novel MERS-CoV isolates that cause fatal respiratory disease. The 288–330+/+ mice are currently being used to evaluate novel drug, antibody, and vaccine therapeutic countermeasures for MERS-CoV. The chapter starts with a historical perspective on the emergence of MERS-CoV and animal models evaluated for MERS-CoV pathogenesis, and then outlines the development of the 288–330+/+ mouse model, assays for assessing a MERS-CoV pulmonary infection in a mouse model, and describes some of the challenges associated with using genetically engineered mice.


    A little more info from the study-

    "In February of 2018 MERS-CoV was listed as a priority on the R&D Blueprint for the global strategy and preparedness plan outlined by the World Health Organization (WHO) [1]. The R&D Blueprint includes viruses that pose a global public health risk, and for which there are no available therapeutic countermeasures"

    "A seminal study identifying the MERS-CoV receptor as human dipeptidyl peptidase IV (hDPP4) [49], and publication of the crystal structure of hDPP4 interacting with the receptor binding domain (RBD) of the MERS-CoV spike protein [50], exposed tropism determinants critical for susceptibility. Dipeptidyl peptidase IV contact amino acids at the hDPP4/RBD interface are highly conserved among MERS-CoV-susceptible mammalian species (human, camel, and bat)"

    "Genetic engineering of mice would be necessary to develop preclinical MERS-CoV mouse models with respiratory phenotypes that reflected clinical outcomes in patients."

    "In some studies, higher viral loads could be detected in the brain compared to the lungs [39, 40]. Mice with infections of the central nervous system (CNS) exhibited encephalitis that corresponded with the kinetics of mortality [39]. Currently, there is no evidence to support a CNS component associated with MERS-CoV pathogenesis in humans"
    "DPP4 interacts with and modifies heterologous protein molecules involved in nociception, neuroendocrine function, metabolism, cardiovascular function, immune regulation, and infection"

    "Adaptive evolution of human MERS-CoV in the hDPP4-KI mouse resulted in mouse-adapted viruses that evoked a lethal respiratory phenotype with little involvement of extrapulmonary tissues. The lethal respiratory phenotype is a consequence of novel mutations acquired during adaptive evolution"

    "Shortly after the emergence of MERS-CoV into humans in 2012, the CRISPR/Cas9 genome editing technology became available for applications to modify mammalian genomes in vitro and in vivo"


    I’m not trying to imply anything but using CRISPR to put human peptides that corona viruses attach on to in mice seems risky, if like the quote above covid19 becomes a brain virus rather than lungs the public will become hyper hysterical.
     
  3. OP
    Drareg

    Drareg Member

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    This is the human peptide -Dipeptidyl peptidase-4 - Wikipedia

    "DPP4 plays a major role in glucose metabolism. It is responsible for the degradation of incretins such as GLP-1.[10] Furthermore, it appears to work as a suppressor in the development of some tumors".

    "Animal studies suggest its pathogenetic role in development of fibrosis of various organs, such as liver and kidney"

    "Middle East respiratory syndrome coronavirus has been found to bind to DPP4. It is found on the surface of cells in the airways (such as the lungs) and kidneys. Scientists may be able to use this to their advantage by blocking the virus's entry into the cell.[19]"
     
  4. methylenewhite

    methylenewhite Member

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    Crisp uses viruses to deliver genes. Covid could be a gene delivery Trojan Horse. Although Trojan Horse metaphor is not correct you got my point.
     
  5. boris

    boris Member

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    Look into "Gene Drive Files":

    Disclosed emails reveal military as top funder; Gates Foundation paying $1.6 million to influence UN expert process

    "Over 1,200 emails released under open records requests reveal that the U.S. military is now the top funder and influencer behind a controversial genetic extinction technology known as “gene drives” – pumping $100 million into the field. The trove of emails, obtained via open records requests, also shed light on a $1.6 million dollar UN gene drive advocacy operation paid for by the Bill and Melinda Gates Foundation."

    "Emerging Ag, a privately-held public relations firm, received over $1.6 million from the Bill and Melinda Gates Foundation to work on gene drive topics and to focus on exerting influence on the United Nations Convention on Biological Diversity (CBD), the key body for gene drive governance. Following calls in 2016 for a globalmoratorium on the use of gene drive technology, the CBD sought input from scientists and experts in an online forum. According to the Gene Drive Files, Emerging Ag recruited and coordinated over 65 experts, including a Gates Foundation senior official, a DARPA (Defense Advanced Research Project Agency) official, and government and university scientists, in an private attempt to flood the official UN process with their coordinated inputs."
     
  6. OP
    Drareg

    Drareg Member

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    One of the authors from the above study genetically engineered mice also has this study which I find interesting ,it seems the WHO have been encouraging research on coronavirus through anticipating future novel coronaviruses in mouse model research ,essentially encouraging the adaptation of the coronavirus in the lab before it adapts in the wild - so to speak.
    That’s not reassuring in the slightest when we look at WHO the WHO is.

    Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice. - PubMed - NCBI


    Modeling pathogenesis of emergent and pre-emergent human coronaviruses in mice.
    The emergence of highly pathogenic human coronaviruses (hCoVs) in the last two decades has illuminated their potential to cause high morbidity and mortality in human populations and disrupt global economies.
    Global pandemic concerns stem from their high mortality rates, capacity for human-to-human spread by respiratory transmission, and complete lack of approved therapeutic countermeasures.
    Limiting disease may require the development of virus-directed and host-directed therapeutic strategies due to the acute etiology of hCoV infections.
    Therefore, understanding how hCoV-host interactions cause pathogenic outcomes relies upon mammalian models that closely recapitulate the pathogenesis of hCoVs in humans.
    Pragmatism has largely been the driving force underpinning mice as highly effective mammalian models for elucidating hCoV-host interactions that govern pathogenesis. Notably, tractable mouse genetics combined with hCoV reverse genetic systems has afforded the concomitant manipulation of virus and host genetics to evaluate virus-host interaction networks in disease.
    In addition to assessing etiologies of known hCoVs, mouse models have clinically predictive value as tools to appraise potential disease phenotypes associated with pre-emergent CoVs. Knowledge of CoV pathogenic potential before it crosses the species barrier into the human population provides a highly desirable preclinical platform for addressing global pathogen preparedness, an overarching directive of the World Health Organization. Although we recognize that results obtained in robust mouse models require evaluation in non-human primates, we focus this review on the current state of hCoV mouse models, their use as tractable complex genetic organisms for untangling complex hCoV-host interactions, and as pathogenesis models for preclinical evaluation of novel therapeutic interventions.
     
  7. OP
    Drareg

    Drareg Member

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    Gates is clearly co-opted by the intelligence and military at some point. This is ridiculous how involved he is, he is basically an NGO or CIA business front for contemporary times. There is now way a government with all its tentacles would allow him to be so deep in all these industries which happen to revolve around human control unless he was working with them.
     
  8. OP
    Drareg

    Drareg Member

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    Another from the above authors, you don’t exactly feel sold on the idea that covid 19 didn’t originate in a lab after reading through these studies-
    Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease. - PubMed - NCBI

    Adaptive evolution influences the infectious dose of MERS-CoV necessary to achieve severe respiratory disease.

    "We recently established a mouse model (288-330+/+) that developed acute respiratory disease resembling human pathology following infection with a high dose (5 × 106 PFU) of mouse-adapted MERS-CoV (icMERSma1). Although this high dose conferred fatal respiratory disease in mice, achieving similar pathology at lower viral doses may more closely reflect naturally acquired infections.
    Through continued adaptive evolution of icMERSma1 we generated a novel mouse-adapted MERS-CoV (maM35c4) capable of achieving severe respiratory disease at doses between 103 and 105 PFU. Novel mutations were identified in the maM35c4 genome that may be responsible for eliciting etiologies of acute respiratory distress syndrome at 10-1000 fold lower viral doses. Importantly, comparative genetics of the two mouse-adapted MERS strains allowed us to identify specific mutations that remained fixed through an additional 20 cycles of adaptive evolution. Our data indicate that the extent of MERS-CoV adaptation determines the minimal infectious dose required to achieve severe respiratory disease"
     
  9. OP
    Drareg

    Drareg Member

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    DNA vaccine researcher, same guy-

    http://atm.amegroups.com/article/view/12764/13471

    "In 2016 Inovio utilized its proprietary platform to initiate phase I clinical DNA vaccine studies for MERS-CoV, Zika virus, and Ebola virus (INOVIO Pharmaceuticals). DNA vaccines provide a number of advantages over other vaccine approaches such as recombinant protein and live-attenuated vaccines: (I) development is more cost effective and easier; (II) there is no risk of reversion; (III) membrane protein targets (e.g., viral membrane glycoproteins) can be readily expressed in mammalian cells; and (IV) prior phase I clinical studies indicate that there is little inflammation/toxicity associated with a DNA vaccine (15). Despite these advantages, there are no approved DNA vaccines for use in humans. DNA vaccines that elicit an effective immune response to infectious disease antigens continues to be a challenge in humans, as described in a number of former clinical trials (15)’
     
  10. OP
    Drareg

    Drareg Member

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    CRISPR gone wrong, there is a lot of articles like this one out there, I was naively interested in CRISPR at the start-
    Potential CRISPR damage has been 'seriously underestimated,' study finds


    "The results come hard on the heels of two studies that identified a related issue: Some CRISPR’d cells might be missing a key anti-cancer mechanism and therefore be able to initiate tumors.
    The DNA damage found in the new study included deletions of thousands of DNA bases, including at spots far from the edit. Some of the deletions can silence genes that should be active and activate genes that should be silent, including cancer-causing genes."

    "But just as critics of last month’s studies asked why, if CRISPR’d cells can initiate cancer, no CRISPR’d mice had turned up with tumors, so scientists raised similar questions about the new genomic havoc finding: Why don’t scientists see it when they analyze the DNA of CRISPR’d cells?
    “You find what you look for,” said Bradley. “No one is looking at the impact [of these DNA changes] on downstream genes.”

    And we know well on this forum they find what they look for, just like the bastardizing of progesterone research with artificial progestene etc.

    CRISPR CAS9 is been touted as laser guided snipping of the DNA , just like SSRI’s made it sound like the pill was incredible accurate at specific receptors ,we now know it has a lucky side effect of increasing allopregnenolone.
    CRISPR CAS9 is marketed the same way as an ssri, in reality it’s about as accurate as a wrecking ball.

    And one last quote from the article to sum up big pharma newest omen child biotechnology -

    "The possibility of adverse consequences from CRISPR’d cells has caused some company officials to argue that if, say, their therapy cures a child of a devastating disease, but increases her risk of cancer, that might be an acceptable trade-off"


     
  11. OP
    Drareg

    Drareg Member

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    I think it becomes clearer as to what Bill Gates links to Jeffrey Epstein the child sex trafficker was, Epstein we know had a fascination with theories of superior DNA, insemination of women at Wes lexners ranch, we know the ruling class have had this obsession since the days of blood lines, we can assume Bill Gates with his parents connections to elite types with eugenic fantasies is continuing on the delusional ideology, Epstein worked for intelligence, essentially for the elites.

    Epstein would get people in line with blackmail if they refused to go along with the genetically determined eugenic styled ideology, academics and Silicon Valley types, easy targets when it comes to sexual issues, these are the big influencers of society.

    Its almost a certitude then that contemporary influencers on you tube and Instagram are now been targeted by the same network, same with influential thinkers who are not in academia as academia is slowly dying.
     
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