BCAA’s Impact Health And Lifespan Indirectly Via Amino Acid Balance And Appetite

Discussion in 'BCAA's' started by Mito, Apr 30, 2019.

  1. Mito

    Mito Member

    Joined:
    Dec 10, 2016
    Messages:
    1,409
    “Elevated branched-chain amino acids (BCAAs) are associated with obesity and insulin resistance. How long-term dietary BCAAs impact late-life health and lifespan is unknown. Here, we show that when dietary BCAAs are varied against a fixed, isocaloric macronutrient background, long-term exposure to high BCAA diets leads to hyperphagia, obesity and reduced lifespan. These effects are not due to elevated BCAA per se or hepatic mammalian target of rapamycin activation, but instead are due to a shift in the relative quantity of dietary BCAAs and other amino acids, notably tryptophan and threonine. Increasing the ratio of BCAAs to these amino acids results in hyperphagia and is associated with central serotonin depletion. Preventing hyperphagia by calorie restriction or pair-feeding averts the health costs of a high-BCAA diet. Our data highlight a role for amino acid quality in energy balance and show that health costs of chronic high BCAA intakes need not be due to intrinsic toxicity but instead are a consequence of hyperphagia driven by amino acid imbalance.”

    Branched-chain amino acids impact health and lifespan indirectly via amino acid balance and appetite control | Nature Metabolism
     
  2. whit

    whit Member

    Joined:
    Feb 4, 2016
    Messages:
    440
    Gender:
    Male
    Are they supplamenting BCAA or just looking at elevated levels in the blood?

    Since when was serotonin suppression a bad thing?
     
  3. CLASH

    CLASH Member

    Joined:
    Sep 15, 2017
    Messages:
    749
    Gender:
    Male
    I couldnt access the ful study but its looks like a hypothesis as opposed to an actual study. It seems that theyre combining a bunch of assumed positions to create this hypothesis:

    Elevated BCAAS lower serotonin-> lowered serotonin increases appetite-> increased appetite means increased calories-> increased calories means obesity (calories in/ calories out)-> increased obesity means increased morbidity and mortality

    I think this would be very difficult to prove.

    I think @Mito posted it specifically to show you can lower central serotonin using BCAA.
     
  4. whit

    whit Member

    Joined:
    Feb 4, 2016
    Messages:
    440
    Gender:
    Male
    That's how it seemed.
    I think you are correct.
    I've found BCAA to be a good tool for recovery.
    Thanks for the clarification.
     
  5. Rafael Lao Wai

    Rafael Lao Wai Member

    Joined:
    Jun 16, 2017
    Messages:
    875
    Gender:
    Male
    This has actually been proven to be false by another study that showed that serotonin antagonists such as cyproheptadine increase lifespan by 20-30%. It is well known that serotonin antagonists increase hunger, and I think the increased hunger is a sign of vitality. Indeed, the assumption that eating more leads to weight gain is a necessary( and false) assumption that is needed to build the hypothesis that low serotonin( and, consequently, things that lower it) is bad. Considering that weighing too little is also bad, we have another benefit of lowering serotonin: avoidance of cachexia or tissue wasting.
     
  6. magnesiumania

    magnesiumania Member

    Joined:
    Jul 17, 2018
    Messages:
    294
    Gender:
    Male
    Obesity is nothing but blue light toxicity as leptin is a photoreceptor detroyed by fake light. So many metabiloc aspects are linked to your light environment. Like b12 deficiency which is nothing but lack of strong UV that modulate it aswell as folate.
     
Loading...