nicotine

This study looked at the effect of microdoses (2 μg/mL drinking water) of nicotine on mice. Nicotine was able to rescue the rate limiting enzyme for NAD synthesis, NAMPT, and improve NAD levels. This comes of course with all the goodies of a higher NAD/NADH ration, in this case: increase in...

I have embarked on a self experiment involving 2mg nicorette chewing gum and a specific hand-movement 'challenge.' This post is my introduction to the idea and my first experience report, with it I invite criticisms aimed at improving the experimental methods. My protocol: -I film myself...

Nicotine seems to have pro- and anti-inflammatory effects. Its increase in COX2 would be pro inflammatory. On the other hand nicotine has some interesting anti-endotoxin effects, with endotoxin beeing one the biggest promoters of inflammation in the body. This study suggests 2 mechanisms of...

Anyone know of other substances or ways to lower the conversion of DHT to 3adiol other than nicotine? I suspect this is one of my issues potentially after gaining a lot of weight so looking for ways to improve this as I work on lowering body fat. Nicotine helps give me that calm masculine...

A very interesting article, on a topic that has been studied for decades but has not seen much mainstream media exposure mostly because it does not fit the narrative. Namely, that "addictions", including smoking, are mostly genetically determined and not much can be done about them except manage...

I am looking to take Nicotine or Tobacco daily for stress - I'm not a regular user at the moment but nothing compares in terms of reduction of stress - from what I understand: FFA increase Driving down of Insulin High acetylcholine activity It is also said here that if the blood becomes too...

My own observations have found that chronic cigarette smoking alters the function of the kidneys, at the local and nervous level. This disruption in the quantitative and qualitative efficiency in the kidneys sets the entire body up for a state of deranged metabolism. The kidneys are critical for...

The inflammatory condition, called rheumatoid arthritis or rheumatism, is marked by degeneration and pain in the joints, muscles, and connective tissues. The disease shares many traits with other inflammatory “autoimmune” conditions like multiple sclerosis and lupus, but is especially associated...

Choline and acetylcholine are another topic that often pops up online. Cholinergic drugs are still the main "treatment" for Alzheimer, even though all of them are abject failure clinically. Ray has written about the excititoxic properties of acetylcholine, and how estrogen manifests its effects...

"Nicotine significantly reduced erectile responses to the erotic films (P = 0.02), corresponding to a 23% reduction in physiological sexual arousal. This occurred in 16 of 20 men with valid physiological recordings. Nicotine had no significant effect on continuous subjective ratings of sexual...

Conterversial study. It appears nicotine self administration modifies the female type approach strategy to solving problems. It's interesting to note how a substance can modify/adapt behaviour like this under stress, a better adaptive substance may be available, the female type strategy may...

Good study showing how adults get an increased spike in on administration in cardiac norepinephrine and another cardiac norepinephrine spike on withdrawal . It mentions smoking but like many studies on smoking they only use nicotine administration. Equally important, the long-term changes...

The mitochondrial uncoupling effect of caffeine, thyroid, and other substances has been discussed on the forum. Nicotine also uncouples mitochondrial proteins- specifically: Uncoupling Protein 1 (UCP1) Fasting and food restriction lowers expression of UCP1 Nicotine increases expression of UCP1...

Nicotine is the main active compound in tobacco and thus the main active compound in tobacco cigars and cigarettes. Many studies have painted a picture of the negative health effects brought on by smoking. It is important however to differentiate between smoking tobacco and consumption of...