inhibitor

  1. haidut

    Fluoride In Tap Water Could Be A Causative Factor In Diabetes

    While the public health authorities continue their mantra on the "benefits" of fluoride for teeth and bone health, there are quite a few research groups that have been producing solid evidence to the contrary. As many of you know, fluoride is a proven thyroid inhibitor. As such, it is expected...
    • haidut
    • Thread
    • antagonist diabetes fluoride inhibitor metabolism tap water thyroid
    • Replies: 32
    • Forum: Scientific Studies
  2. haidut

    Estrogen Causes Epilepsy/seizures; Aromatase Inhibitors Are Viable Treatment

    In perhaps what is one of the most striking and open confirmations of Ray's views, this study finally acknowledges what the man has been saying for years. Estrogen is a major cause (and maybe even THE cause) of epilepsy and its associated seizures, and inhibiting estrogen synthesis may be a...
    • haidut
    • Thread
    • aromatase epilepsy estrogen inhibitor seizures treatment
    • Replies: 16
    • Forum: Scientific Studies
  3. haidut

    Circadian Clock Dysruptions Driven By Adrenal Activity (cortisol)

    If the results of this study translate to humans then taking a little pregnenolone or progesterone (which restrain excessive cortisol release) may allow people to quickly adapt their circadian clock to a new environment as a result of long flights or working in prolonged conditions of artificial...
    • haidut
    • Thread
    • 11β-hsd1 adaptation adrenal circadian rhythm clock corticosterone cortisol inhibitor metyrapone rhythm stress
    • Replies: 0
    • Forum: Scientific Studies
  4. haidut

    Achilles Heel Of Cancer Found - Its Addiction To Fat

    The public propaganda message has always been that cancer cells are addicted to glucose. As a result of that belief, one of the so-called "new wave" therapies in the treatment of cancer is to "starve" the cancer cells of glucose and hope that they die on their own. This usually has disastrous...
    • haidut
    • Thread
    • addiction aspirin c75 cancer doxycycline emodin endothelial lipase fat foxa heel inhibitor lipg niacinamide orlistat study
    • Replies: 28
    • Forum: Scientific Studies
  5. haidut

    Pregnenolone For Protection Against Melanoma

    Ray has written a few times on the topic of "moles" and how he treated his with DHEA, T3 and progesterone. While he did not mention pregnenolone, I always wondered if it would have a similar effect as animal studies with pregnenolone noted lack of melanoma in treated animals subjected to UV...
    • haidut
    • Thread
    • aggressiveness inhibitor melanoma metastases pregnenolone trpm1
    • Replies: 4
    • Forum: Scientific Studies
  6. haidut

    Pregnenolone Is The Most Potent Inhibitor Of The Stress Signal (CRH)

    I think this study should finally put to rest the arguments and debates of whether pregnenolone raises or lowers cortisol, and how it affects the stress response overall. I posted a similar study, which showed that the pregnenolone metabolites progesterone and allopregannolone potently inhibited...
    • haidut
    • Thread
    • acth allopregnanolone artemisia cortisol crf crh inhibitor pregnenolone stress
    • Replies: 116
    • Forum: Scientific Studies
  7. haidut

    Niacinamide Is Androgenic And Increases Dht Effects/signaling

    I just posted a study showing that inhibition of SIRT1 is anti-estrogenic, and SIRT1 inhibitors like niacinamide have similar effects to the estrogen receptor antagonist fulvestrant. Niacinamide Is Anti-estrogenic | Ray Peat Forum This study shows that, again through inhibition of SIRT1...
    • haidut
    • Thread
    • androgenic androgens dht hdac inhibitor niacinamide receptor sirt1 sirtuins study
    • Replies: 48
    • Forum: Scientific Studies
  8. Zachs

    Coconut Oil Reduced DHT By Inhibiting 5-ar?

    This was something I researched a bit a few years ago when first learning about Ray Peat and his affinity for coconut oil. I actually asked him this question but he seemed to not know the answer. Lauric acid among other fatty acids is known for blocking the conversion of DHT by inhibiting...
    • Zachs
    • Thread
    • 5-alpha reductase coconut oil dht inhibitor reduction study
    • Replies: 11
    • Forum: Scientific Studies
  9. haidut

    Hypoxia Biomarker HIF-1 Is A Master Inhibitor Of Metabolism

    In another confirmation of Peat's ideas, this human study demonstrates that hypoxia, through increased levels of HIF-1 directly inhibit oxidative metabolism and activate the enzyme pyruvate dehydrogenase kinase (PDK). PDK inhibits the oxidation of pyruvate by inhibiting the enzyme pyruvate...
  10. haidut

    Hypoglycin - A Powerful Fatty Acid Oxidation Inhibitor

    I just posted another thread on the Randle Cycle. That study mentioned a natural compound called hypoglycin. It is a fatty acid oxidation inhibitor and as such, despite its toxicity if used carelessly, can be a viable alternative to people with conditions like heart failure, type I diabetes...
  11. haidut

    Aspirin Inhibits Tryptophan Absorption From The Intestine

    Peat has written about the benefits of tryptophan restriction for overall health and metabolism. Unfortunately, there are few reliable methods of reducing tryptophan absorption and most people have to resort to simply limiting consumption of foods high in tryptophan. It would be nice if there...
  12. Dan W

    Coffee And Cocoa As Aromatase Inhibitors

    I had to post this because we've gone nearly 17 minutes without discussing an aromatase inhibitor :lol: I don't have access to the full text of this study, but it's referenced elsewhere as showing coffee and cocoa strongly inhibiting aromatase in a microsomal assay...
  13. haidut

    Methylene Blue (MB) Is A Potent Aromatase Inhibitor

    I can't find the original reference on PubMed or anywhere else, so if someone can dig that up for me I'd really appreciate it. For now, we'll have to accept the following statement from the book (the book seems rather legit btw). https://books.google.com/books?id=plBoB ... se&f=false...
  14. haidut

    The Tetracycline Antibiotics Inhibit Mitochondrial Respiration

    I posted a study about a month ago showing that the tetracycline class of antibiotics are potent inhibitors for a large number of cancer types. The proposed mechanism of action in that study was the fact that the tetracyclines were very toxic to the tumor mitochondria. This study found that the...
    • haidut
    • Thread
    • inhibitor mitochondrial respiration study tetracycline
    • Replies: 27
    • Forum: Scientific Studies
  15. J

    Taurine Inhibits Endotoxic Translocation

    According to a paper by Thorne Research. They cite these papers: Intestinal endotoxin translocation in endotoxemic rats Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?
    • j.
    • Thread
    • endotoxin inhibitor study taurine
    • Replies: 0
    • Forum: Scientific Studies
  16. haidut

    Pregnenolone, Progesterone And Androsterone Are Aromatase Inhibitors

    I have seen some people in the forum claim that they thought pregnenolone increased their estrogen levels. According to this study, pregnenolone should in fact lower estrogen by inhibiting aromatase. Peat has already written extensively on progesterone being a known aromatase inhibitor, so that...
    • haidut
    • Thread
    • androsterone aromatase aromatase inhibition dht inhibitor pregnenolone progesterone
    • Replies: 125
    • Forum: Scientific Studies
  17. haidut

    Vitamin B6 Is A Dopamine Agonist And Prolactin Inhibitor

    I mentioned in some of my other posts that vitamin B6, and especially the cheap pyridoxine hydrocholride type, was used several decades ago to treat hyperprolactinemia and dopamine deficiencies. The dosages used vary widely, but the lowest I have seen used is 10mg daily, while the highest was...
  18. haidut

    Selenium Is Anti-estrogenic (aromatase Inhibitor)

    Another confirmation that most of the substances favored by Peat have anti-estrogenic action even if he did not directly state it. http://www.ncbi.nlm.nih.gov/pubmed/22128327
  19. haidut

    Vitamin E (tocopherol) Is A Potent Aromatase Inhibitor

    Hi all, As you know Ray has written extensively on the benefits of Vitamin E though its actions as an estrogen antagonist. I opsted some studies that show that tocopherols act directly like estrogen "receptor" antagonist and this may explain some of their anti-estrogenic properties. However...
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