deiodinase

[ edit : part of post moved from Anybody Know More On The Role Of Type 3 Deiodinase? ] I found this one by chance. Don't know if it helps. Conversion of T3 and rT3 to 3,3'-T2: pH dependency. - PubMed - NCBI

Abstract OBJECTIVE: Plasma levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) are reduced in individuals with defective insulin signaling. Initial studies using liver-specific insulin receptor (InsR) knockout mice identified reduced expression of type 1...

Hypothalamic-pituitary-thyroid (HPT) axis activity is important for energy homeostasis, and is modified by stress. Maternal separation (MS) alters the stress response and predisposes to metabolic disturbances in the adult. We therefore studied the effect of MS on adult HPT axis activity. Wistar...

Abstract Neutrophils are important effector cells of the innate immune system. Thyroid hormone (TH) is thought to play an important role in their function. Intracellular TH levels are regulated by the deiodinating enzymes. The TH-inactivating type 3 deiodinase (D3) is expressed in infiltrating...

Abstract It has been proven that either excess or deficiency of thyroid hormones has harmful influence on the cardiovascular system function. On the other hand, severe systemic conditions like myocardial infarction or severe heart failure may affect thyroid hormones secretion and their...

Millions of levothyroxine-treated hypothyroid patients complain of impaired cognition despite normal TSH serum levels. This could reflect abnormalities in the type 2 deiodinase (D2)-mediated T4-to-T3 conversion, given their much greater dependence on the D2 pathway for T3 production. T3 normally...

Does anybody know of an epigentics way to down regulate this enzyme? Some studies below. Expression of D3 in human cancers. This enzyme deactivates t3 and t4 hormone. Deiodination in cancer growth: the role of type III deiodinase. - PubMed - NCBI It's a common denominator in heart disease...