cortisol

  1. haidut

    Stress Leads To Lower Dopamine And More Drinking

    The study was really on alcohol consumption what affects it. It has been known since the 1960s that people drink more when under stress but to this day mainstream medicine denies that there is a causative link between stress and substance abuse. I posted a few studies showing that "addicts" have...
    • haidut
    • Thread
    • addiction alcohol alcoholism cortisol crh dopamine drinking ethanol gaba glucocorticoid pregnenolone
    • Replies: 64
    • Forum: Scientific Studies
  2. A

    Megadosing Vitamin C? (Increase DHEA, Lower Cortisol)

    Since DHEA is illegal in my country I have been looking for natural ways to increase it through diet/supplements. I found this study where the participants megadosed with 4 grams of Vitamin C daily for ten days. They splitted the dose to 1 gram every 6 hour : Annals NY Acad of Sciences, Jul...
    • Andreas
    • Thread
    • cortisol dhea supplemental vitamin c
    • Replies: 32
    • Forum: C
  3. haidut

    Aspirin Treats Depression By Lowering Cortisol And Inflammation

    This was an animal study but it follows a long thread of other studies and some of them with humans. Unfortunately, so far all of the human studies used aspirin only as an adjuvant but hopefully as new studies like the one below continue to appear the opinion on aspirin will change. Ray has...
    • haidut
    • Thread
    • antidepressant aspirin cortisol crf crh depression inflammation interferon
    • Replies: 9
    • Forum: Scientific Studies
  4. Drareg

    High Cortisol In 5-year-old Children Causes Loss Of DNA Methylation In SINE Retrotransposons: A

    Whats interesting here is it's showing cortisol demethylating dna? Lowering cortisol in certain circumstance might not be ideal? High cortisol in 5-year-old children causes loss of DNA methylation in SINE retrotransposons: a possible role for ZNF263 in stress-related diseases "Childhood stress...
  5. haidut

    Fertility Problems In Women Could Be Due To High Cortisol

    Cortisol is highly antagonistic to progesterone - i.e. it both directly inhibits synthesis of progesterone and activates aromatase, so elevated cortisol results both in deficiency of progesterone and excess of estrogen. This human study found that women who had issues getting pregnant had...
  6. haidut

    Androsterone - A Potent Steroidal Aromatase Inhibitor

    It is well-known in medical circles (at least in doctors over 50) that some androgens like DHT are potent aromatase inhibitors (AI). In fact, before the advent of modern AI drugs like letrozole, anastrozole and fadrozole the 5-AR androgens were a mainstream therapy for estrogen-receptor-positive...
    • haidut
    • Thread
    • 5-alpha reductase androsterone aromatase aromatase inhibition cortisol dht estrogen estrone
    • Replies: 36
    • Forum: Scientific Studies
  7. haidut

    Hypothyroidism (Cortisol, Prolactin And Adrenal Hyperactivity) Causes Balding

    I wanted to post this as quite a few people have raised points about androgens causing hair loss. The so-called "male pattern baldness" (MPB) exists in women as well and is in fact quite common in older women (as it is in men) since 50%+ of older women have some stage of baldness as well. Unless...
    • haidut
    • Thread
    • androstenedione baldness cortisol estrogen hair loss hypothyroidism mpb prolactin stress study
    • Replies: 273
    • Forum: Scientific Studies
  8. haidut

    DHEA Protects From Endotoxin Effects And Lethality

    Sepsis is the leading cause of death in patients hospitalized for infections. There is no accepted treatment, at least officially, that can change the course of the sepsis for the better. This study shows that a single HED dose of as little as 5mg - 7mg daramatically increased survival from a...
    • haidut
    • Thread
    • cortisol dhea endotoxin lethality lps prevention protective tnf
    • Replies: 2
    • Forum: Scientific Studies
  9. haidut

    Lisuride - Liquid Lisuride For Lab/R&D

    After many months of often fruitless searching and negotiations with chemical vendors from all over the world, I am pleased to finally announce the release of our Lisuride product. This is perhaps the most anticipated product we have ever released and it is for a good reason. The recent...
    • haidut
    • Thread
    • cortisol dopamine lisuride prolactin serotonin
    • Replies: 601
    • Forum: IdeaLabs
  10. P

    Effects Of Estrogen Versus Estrogen And Progesterone On Cortisol And Interleukin-6

    http://www.maturitas.org/article/S0378-5122%2808%2900258-2/abstract Abstract Objectives The purpose of this study was to compare the effects of 3 months of estrogen replacement therapy, estrogen plus progesterone replacement therapy and a placebo, on the resting cortisol and interleukin-6...
  11. haidut

    Emotional Stress Linked To Diabetes

    Considering the direct connection between stress, cortisol, and insulin resistance, I think the link should not be surprising but apparently it is to the fellows in white coats. http://www.psyneuen-journal.com/article/S0306-4530%2816%2930134-2/abstract Stress-diabetes link detailed in new study...
  12. haidut

    The Myth Of Pregnenolone Steal

    I think this is a very persistent myth and one that is reigning supreme on all forums except this one. Even here, we occasionally get challenged and statements referring to this flawed idea. Here is something that will hopefully clarify why the steroid "steal" is a flawed idea. Among the more...
    • haidut
    • Thread
    • cortisol dhea hypothyroidism inflammation pregnenolone pregnenolone steal steal stress
    • Replies: 9
    • Forum: Scientific Studies
  13. P

    Cortisol Decreases The Synthesis Of Hyaluronic Acid By Human Aortic Smooth Muscle Cells In Culture

    Cortisol decreases the synthesis of hyaluronic acid by human aortic smooth muscle cells in culture. - PubMed - NCBI The effect of cortisol on the synthesis of glycosaminoglycans (GAGs) was studied in cultured human aortic smooth muscle cells. Cortisol, at a level slightly exceeding the...
    • paymanz
    • Thread
    • atherosclerosis connective tissue cortisol extracellular matrix glycosaminoglycans hyaluronic acid skin stress study
    • Replies: 0
    • Forum: Articles & Scientific Studies
  14. haidut

    Stress Increases Estrogen In Females And Impairs Cognitive Function

    I already posted several studies showing that stress elevates estrogen in males. So much for estrogen being a beneficial female hormone. Acute stress persistently enhances estrogen levels in the female rat. - PubMed - NCBI "...Here we tested whether exposure to either tailshock or swim stress...
    • haidut
    • Thread
    • cognition cortisol estrogen female learning memory stress
    • Replies: 0
    • Forum: Scientific Studies
  15. haidut

    Depression May Be Caused By Estrogen In Females And Cortisol In Males

    A very interesting study, which points to a potential difference in the depression etiology between the sexes. However, given that cortisol is one of the strong activators of the aromatase enzyme, high cortisol also means high estrogen in males. The study openly discusses the effect of stress on...
    • haidut
    • Thread
    • cortisol crf depression estrogen female males serotonin tph tph1
    • Replies: 35
    • Forum: Scientific Studies
  16. haidut

    DHEA Enhances Cortisol Degradation

    DHEA is one of the body's primary defense mechanisms against cortisol. Not only does DHEA act like a functional anti-glucocorticoid and protect tissues but as I posted a few month ago, DHEA blocks new cortisol synthesis by inhibiting the enzyme 11β-HSD1 in micromolar concentrations, which is...
  17. haidut

    Aspirin (salicylic Acid) Inhibits Cortisol Synthesis

    I posted several studies on aspirin and sodium salicylate being effective in reversing insulin resistance and type II diabetes in humans. However, to my knowledge the mechanism of action of aspirin and other prodrugs for salicylic acid has never been publicly elucidated even though Ray has...
    • haidut
    • Thread
    • 11β-hsd1 adipose tissue aspirin cortisol inhibition insulin sensitivity salsalate sodium salicylate study
    • Replies: 10
    • Forum: Scientific Studies
  18. haidut

    Coffee Inhibits Cortisol Synthesis

    I was really pleased to see that study for two reasons. First, it gives more credibility to Peat's statement that coffee/caffeine do NOT boost cortisol, contrary to what many people claim and would like to believe. This matches well the few animal studies I have posted showing caffeine and...
    • haidut
    • Thread
    • 11β-hsd1 article coffee cortisol espresso inhibition
    • Replies: 60
    • Forum: Scientific Studies
  19. haidut

    Circadian Clock Dysruptions Driven By Adrenal Activity (cortisol)

    If the results of this study translate to humans then taking a little pregnenolone or progesterone (which restrain excessive cortisol release) may allow people to quickly adapt their circadian clock to a new environment as a result of long flights or working in prolonged conditions of artificial...
    • haidut
    • Thread
    • 11β-hsd1 adaptation adrenal circadian rhythm clock corticosterone cortisol inhibitor metyrapone rhythm stress
    • Replies: 0
    • Forum: Scientific Studies
  20. haidut

    Stress Increases Risk For Alzheimer Disease (AD)

    This is probably not surprising for any forum user, but official medical guidelines still claim that stress has no known long-term direct effects on health except in "genetically-predisposed individuals". Stress may increase risk for Alzheimer’s disease "...Fewer than ten percent of Alzheimer...
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