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cortisol
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Cortisol/Estrogen Impair Fertility; Progesterone/Pregnenolone Improve It
I posted a study s few months ago about the role of progesterone in ensuring proper sperm motility, and as such being crucial for male fertility. Male Fertility Requires Progesterone And Antagonism Of A PUFA Metabolite This new study from the same authors analyzed the effects of a few other...- haidut
- Thread
- cortisol estrogen fertility pregnenolone pregnenolone sulfate progesterone sperm motility testosterone
- Replies: 7
- Forum: Scientific Studies
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The Lower Your Cortisol Levels, The Younger You Look
Peat has this quote popping up on the forum every once in a while. “The main features of aging can be produced... | Ray Peat Forum "..."...The main features of aging can be produced directly by administering excessive amounts of cortisol. These features include atrophy of skin, arteries, muscle...- haidut
- Thread
- aging apprearance cortisol epigenetic facial looks perceived youth
- Replies: 92
- Forum: Scientific Studies
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Meal Timing Circadian Rythym Cortisol
Info graph here just incase you cant see it- beta pandemic
- Thread
- circadian rhythm cortisol meal frequency / timing
- Replies: 2
- Forum: Mind, Sleep, Stress
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Diamant - Adamantane Solution For Lab/R&D
I first became interested in adamantane when I read about it in one of ray's articles. According to Ray it seems to have a stabilizing and structurally protective effects on the water inside the cell, and its commercial derivatives are all know to be anti-excitotoxic. The problem of Alzheimer's... -
Stress Makes Parents Selfish And Makes Them Neglect Their Children
I think every stressed parent can testify to the validity of this finding. Even if stress does not make a parent more selfish it certainly makes a parent less attentive because of the diversion of energetic resources to deal with the stressor. So, this study suggests that many (if not all) cases...- haidut
- Thread
- children corticosterone cortisol greed neglect parents sellfish stress
- Replies: 6
- Forum: Scientific Studies
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High Cortisol / Testosterone Ratio As A Likely Cause Of PTSD
As the study below says the role of cortisol (C) in mood disorders has been known for more than 30 years. Cortisol's role in depression, schizophrenia, bipolar, and eating disorders is well known even in mainstream psychiatry and many of the new drugs in pharma pipeline are aimed at suppressing...- haidut
- Thread
- cortisol disorder hypothyroidism mood ptsd ratio stress testosterone
- Replies: 18
- Forum: Scientific Studies
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5-AR Inhibitor Drugs Like Finasteride Cause Persistent ED And Lower Testosterone
The FDA has denied for decades that the mainstream drugs for hair loss (MPB) and benign prostate enlargement (BPH) cause any persistent problems. It was in the minds of the users, the FDA said. Upon discontinuation, the problems were said to disappear within 2-4 weeks. But the reports on long...- haidut
- Thread
- 5-alpha reductase baldness bph cortisol dutasteride erectile dysfunction erection finasteride mpb prostate testosterone
- Replies: 41
- Forum: Scientific Studies
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Solid Evidence That Stress Causes Obesity
The statement in the title should be fairly obvious for most forum members or people following Peat's work. In fact, most endocrinologists are keenly aware of the role of stress and cortisol in causing obesity, metabolic syndrome and diabetes. However, believe it or not, officially the FDA and...- haidut
- Thread
- cortisol cvd diabetes obesity stress
- Replies: 16
- Forum: Scientific Studies
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Insulin Resistance As An Endocrine Disorder
This argument has flared up so many times on this forum and I doubt we have reached any agreement. I am on the side that insulin resistance and obesity are endocrine disorders. There is a group here that maintains that it is the obesity that really triggers it all. This study discusses some of...- haidut
- Thread
- adrenaline cortisol diabetes disorder endocrine hpa hypothyroidism insulin resistance obesity stress
- Replies: 22
- Forum: Scientific Studies
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Mirtazapine Powerfully Lowers Cortisol
Forum member haidut has posted many studies that anti-serotonin drugs lower cortisol, and here's some more evidence that the antidepressant mirtazapine dose the same. Mirtazapine has mixed serotenergic properties, but Ray thinks it might be useful in some situations. It's anti-serotonin and...- DaveFoster
- Thread
- cortisol mirtazapine study
- Replies: 23
- Forum: Scientific Studies
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Gynecomastia Associated With Low Androgens, High Cortisol / Estrogen / Prolactin / LH / FSH
I just wanted to post this study here since there is still controversy in endocrinology circles about exactly what imbalance causes gynecomastia. Ray has written on the role of cortisol and prolactin in causing gyno, which is in addition to the generally accepted view of estrogen being the...- haidut
- Thread
- cortisol estrogen fsh gonadotropin gynecomastia lh pituitary prolactin
- Replies: 9
- Forum: Scientific Studies
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Pregnenolone, Progesterone And DHEA Drop, Cortisol Rises In Aging
I posted a few times about the steroidal characteristics of aging. Many people think there is a drop in testosterone (T) in aging and that is what drives the frailty of aging both in men and women. However, numerous studies show that that total T does not decrease with aging. What does seem to...- haidut
- Thread
- adrenals aging cortisol dhea dht estradiol gonads pregnenolone progesterone steroidogenesis steroids testosterone
- Replies: 29
- Forum: Scientific Studies
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Vitamin D Restores Sensitivity To Cortisol
The so-called "glucocorticoid resistance" is thought be behind a number of degenerative conditions including diabetes, depression, schizophrenia, chronic inflammation, autoimmune conditions, etc. The condition, similar to insulin resistance, is characterized by elevated serum cortisol levels and...- haidut
- Thread
- calcitriol cholecalciferol cortisol glucocorticoid inflammation resistance sensitivity vitamin d
- Replies: 18
- Forum: Scientific Studies
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The Anti-cortisol Mechanism Of Progesterone
I just posted the thread on the anti-cortisol mechanism of pregnenolone. The Anti-cortisol Mechanism Of Pregnenolone As I mentioned in that thread, the Peat has been saying that both pregnenolone and progsterone have anti-cortisol effects, however people have been questioning those statements...- haidut
- Thread
- acceleration antagonist binding cortisol dissociation glucocorticoid progesterone receptor
- Replies: 26
- Forum: Scientific Studies
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The Anti-cortisol Mechanism Of Pregnenolone
One of the recurring arguments on this forum is whether pregnenolone and progesterone (being technically precursor to the glucocorticoids) raise or lower cortisol levels, and whether they have effects opposing or promoting those of the glucocorticoids. The argument advanced by a few people here...- haidut
- Thread
- antagonist cell cortisol glucocorticoid nucleus pregnenolone receptor translocation
- Replies: 12
- Forum: Scientific Studies
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Creatine, Similar To Ketamine, Counteracts Depressive-Like Behavior Induced By Corticosterone Via PI
Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway. - PubMed - NCBI Ketamine has emerged as a novel strategy to treat refractory depression, producing rapid remission, but elicits some side effects that limit its use. In an...- paymanz
- Thread
- corticosterone cortisol creatine depression ketamine
- Replies: 5
- Forum: Articles & Scientific Studies
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Cyproheptadine - Liquid Serotonin Antagonist For Lab/R&D
Due to popular demand, we have released the well-known chemical cyproheptadine as a product for R&D use only. I don't think cyproheptadine needs any introduction here, so I have simply provided the Wikipedia links and some relevant links from the forum. Cyproheptadine - Wikipedia Please note... -
Acne At An Age Older Than 25 May Be A Sign Of Systemic Disease
The topic of acne has come up many times on this forum and appears to be anything but solved. While the pubertal and late teen acne is relatively well understood and often responds quite well to antibiotics or hormonal therapy, acne at an older age is much less understood. The predominant view...- haidut
- Thread
- acne cortisol dhea dhea-s hyperandrogenism pcos prolactin sign systemic systemic disease testosterone
- Replies: 33
- Forum: Scientific Studies
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Palmitic Acid Inhibits Cortisol Synthesis
Palmitic acid has a bad reputation in mainstream medical circles. It is being blamed for insulin resistance, obesity, and even triggering diabetes II. Ray has written a few times about palmitic acid, and has explained that it is one of the few known exogenous factors that can activate the enzyme...- haidut
- Thread
- 11β-hsd1 11β-hsd2 cortisol cortisol synthesis diabetes palmitate palmitic acid study synthesis
- Replies: 3
- Forum: Scientific Studies
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Adrenal Fatigue Real Or Fake?
How important are our adrenal glands to energy production truly? Come across so many articles which mention their significance. It seems as if Peat strongly disagrees with that notion. I know the guy is unparalleled in terms of knowledge but what are some other opinions on this matter?- Jsaute21
- Thread
- adrenal fatigue cortisol health hypoglycemia hypothyroidism
- Replies: 8
- Forum: Symptoms, Causes