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androsterone
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The Thyromimetic Mechanism Of Androsterone (and Other Androgens)
As I posted in one of the androsterone threads, studies in the first half of the 20th century discovered hypocholesteremic and pyrogenic effects of androsterone and many animal models and also in humans. However, the direct mechanism for these effects of androsterone was not elucidated by these...- haidut
- Thread
- androgens androsterone cholesterol estrogen thiouracil thyroglobulin thyroid thyromimetic thyroxine
- Replies: 28
- Forum: Scientific Studies
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The Antidepressant Mechanism Of Androsterone
There is solid evidence that androgens have potent antidepressant effects in both sexes. However, the mechanism of action of that antidepressant effect has not been fully elucidated yet. On the other hand, it is also well known that chemicals that increase the levels of the so-called...- haidut
- Thread
- anabolic androgen androsterone antidepressant bdnf depression estradiol estrogen hpa stress
- Replies: 20
- Forum: Scientific Studies
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The Role Of Steroids In The Prediction Of Affective Disorders In Adult Men
https://www.ncbi.nlm.nih.gov/pubmed/27871861?dopt=Abstract- Koveras
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- allopregnanolone androsterone anxiety depression pregnenolone progesterone steroids testosterone
- Replies: 13
- Forum: Scientific Studies
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RP Email Advice Comment: Androsterone-Associated Joint Pain
Subject: Heard you were looking for androsterone experiences Me: "I experienced profound joint pain and arthropathy, a very severe creaking from every joint. I felt as though i'd aged 60 years in a week. Others have had similar experiences. Dmso may potentiate the hormone excessively. Haidut...- goodandevil
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- androsterone ray peat ray peat email advice
- Replies: 87
- Forum: Email Advice
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Unsaturation = Estrogenic, Saturation = Androgenic
Most people on the forum have read Peat's articles on PUFA and its great synergism with the estrogenic hormones. Peat has written that saturated fats have effects opposite to those of PUFA and there are studies showing feeding saturated fat increases androgen synthesis. I have been researching...- haidut
- Thread
- androgenic androstenedione androsterone estrogenic estrone saturation steroid steroids study testosterone unsaturation
- Replies: 23
- Forum: Scientific Studies
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Androsterone As A Thyromimetic Treatment For Gout And CVD
These studies are old, but I am just posting them here as further support of the thyromimetic properties of androsterone. As we know, thyroid hormone is the primary regulator of levels of uric acid and serum lipids and Ray has recommended improvement of thyroid function as the primary method for...- haidut
- Thread
- androsterone atherosclerosis cholesterol cvd gout study thyroid thyromimetic triglycerides uric acid
- Replies: 5
- Forum: Scientific Studies
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Androsterone Is A Potent Agonist / Activator Of The Farnesoid X Receptor (FXR)
The so-called Farnesoid X Receptor (FXR) is a very interesting nuclear receptor inside the cell. It has a multitude of functions, but one of the main functions includes sensing and controlling the levels and synthesis of bile acids. As I mentioned in a few other posts, nuclear receptors...- haidut
- Thread
- activator agonist androsterone bile acid farnesoid fxr liver mitochondria study
- Replies: 42
- Forum: Scientific Studies
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Androsterone - Liquid Androsterone For Lab/R&D
Edit (10/6/2022): Androsterone seems to be indeed a very effective precursor to DHT in-vivo, as demonstrated by the test results discussed in the thread below. https://raypeatforum.com/community/threads/idea-labs-hair-test-for-androgens.47974/post-856197 EDIT: Since I keep getting questions... -
Remarkable Synergistic Effect Of Androsterone With DHEA
The steroids androsterone (A) and DHEA are considered not very strong androgens in terms of direct activity on androgenic receptors. DHEA is often cited as having 1/10 of the androgenic effects of testosterone (T) and androsterone as having 1/7 of the androgenic effects. While that has been...- haidut
- Thread
- anabolic androgenic androsterone combination dhea optimal ratio study synergistic
- Replies: 258
- Forum: Scientific Studies
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Androsterone - A Neurosteroid With Anti-cancer Activity
Given the recent posts about anti-cancer activity of DHT and other androgens this post is probably not going to surprise anybody. However, I still thought it would be relevant given that in some cancer lines like hepatoma and leukemia, only androsterone displayed chemopreventive and...- haidut
- Thread
- androsterone biomarker cancer hepatoma leukemia lymphoma prevention prognosis treatment
- Replies: 5
- Forum: Scientific Studies
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Androsterone Inhibits Catecholamines (Adrenaline / Noradrenaline)
The neurosteroid androsterone has some very interesting properties, among which is potent GABA agonist activity. Most GABA agonists inhibit the synthesis and/or release of epinephrine (adrenaline) and norepinephrine (noradrenaline) in various animal models and in human trials. The studies below...- haidut
- Thread
- adrenaline androsterone anti-adrenaline antistress catecholamines cvd epinehprine noradrenaline norepinephrine vasorelaxation
- Replies: 25
- Forum: Scientific Studies
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Androsterone - Androgenic Neurosteroid Required For Male Sexual Behavior
I recently posted a study about DHT being required for male sexual behavior and orgasm. That study did not look specifically into whether DHT or one of its downstream metabolites was indeed responsible for male sexual function. This study went a bit further and claims that it is androsterone...- haidut
- Thread
- androgenic androsterone male sexual behavior sexuality
- Replies: 19
- Forum: Scientific Studies
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Androsterone - A Potential Treatment For Insulin Resistance And Diabetes
In another recent thread, I posted about androsterone's potent thyromimetic effects. Given the ability of thyroid hormone to improve insulin sensitivity and even reverse diabetes type II, it would not be surprising that androsterone would also exhibit such effects. And indeed, androsterone...- haidut
- Thread
- androsterone diabetes insulin insulin resistance insulin sensitivity type 2
- Replies: 2
- Forum: Scientific Studies
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Androsterone - The Legal Pro-hormone For Potent 5-AR Derived Androgens
Adnrosterone is a downstream metabolite of DHT and just like DHT it is a 5-AR derived steroid. What is even more interesting is that androsterone is not just a metabolite of DHT but can be converted back to DHT as needed in target tissues where DHT is needed. In fact, androsterone has at least 2...- haidut
- Thread
- 5-alpha reductase androgens androsterone dht prohormone
- Replies: 10
- Forum: Scientific Studies
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Androsterone - The Forgotten But Potent Thyroid Mimetic
Androsterone is one of the 5-AR derived androgens and is a downstream metabolite of DHT. While modern medicine has almost completely forgotten about it, androsterone was well-known and widely used in the 1950s and 1960s under the commercial name Atromid - the most potent cholesterol and...- haidut
- Thread
- androsterone cholesterol hypothyroidism myxedema pyrogenic thyroid thyromimetic triglycerides
- Replies: 18
- Forum: Scientific Studies
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Androsterone - A Potent Steroidal Aromatase Inhibitor
It is well-known in medical circles (at least in doctors over 50) that some androgens like DHT are potent aromatase inhibitors (AI). In fact, before the advent of modern AI drugs like letrozole, anastrozole and fadrozole the 5-AR androgens were a mainstream therapy for estrogen-receptor-positive...- haidut
- Thread
- 5-alpha reductase androsterone aromatase aromatase inhibition cortisol dht estrogen estrone
- Replies: 36
- Forum: Scientific Studies
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Androsterone - Anxiolytic, Sedative, And Anti-Convulsant Neurosteroid
I just posted a thread about androsterone and its potent anti-depressant effects: Androsterone - An Andidepressant Neurosteroid Just like allopregannolone (ALLO), androsterone is 5-AR derived neurosteroid, and just like allopreganolone androsterone is a very potent GABA agonist (even more...- haidut
- Thread
- agonist androsterone anti-seizure anticonvulsant anxiety anxiolytic gaba sedation sedative
- Replies: 29
- Forum: Scientific Studies
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Androsterone - An Andidepressant Neurosteroid
The neurosteroid DHEA has a well-known and studied anti-depressant effect. Several studies have been done in humans using relative high doses of DHEA (50mg - 450mg daily) and they all found positive effects of DHEA on depression. Dehydroepiandrosterone monotherapy in midlife-onset major and...- haidut
- Thread
- androsterone antidepressant depression dhea
- Replies: 2
- Forum: Scientific Studies
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Vitamin D Inhibits The Deactivation Of Androgens
Vitamin D is one of the most versatile substances in Peat world. It is actually a steroid and not a true vitamin, and as a steroid it is expected to have effects on other steroids. Its role in opposing estrogen, together with the other fat-soluble vitamins, is well-known. Now, this study shows...- haidut
- Thread
- androgen receptor androgens androsterone calcitriol deactivation dht glucuronidation inhibitor study vitamin d
- Replies: 12
- Forum: Scientific Studies
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Pregnenolone, Progesterone And Androsterone Are Aromatase Inhibitors
I have seen some people in the forum claim that they thought pregnenolone increased their estrogen levels. According to this study, pregnenolone should in fact lower estrogen by inhibiting aromatase. Peat has already written extensively on progesterone being a known aromatase inhibitor, so that...- haidut
- Thread
- androsterone aromatase aromatase inhibition dht inhibitor pregnenolone progesterone
- Replies: 125
- Forum: Scientific Studies