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Androsterone - The Forgotten But Potent Thyroid Mimetic

Discussion in 'Scientific Studies' started by haidut, Sep 15, 2016.

  1. haidut

    haidut Member

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    Androsterone is one of the 5-AR derived androgens and is a downstream metabolite of DHT. While modern medicine has almost completely forgotten about it, androsterone was well-known and widely used in the 1950s and 1960s under the commercial name Atromid - the most potent cholesterol and triglyceride lowering agent to ever enter clinical practice. Its effects were so rapid and so profound that it became the de-facto standard for prevention of CVD. Within the first 24 hours of administration cholesterol levels dropped about 20% and after a full week had elapsed, cholesterol dropped by 50%+ in most people. A very similar effect was observed for triglycerides and even NEFA.
    THE EFFECT OF ATROMID, AN ORALLY ACTIVE ANDROSTERONE ON SERUM LIPIDS IN NORMAL, HYPERCHOLESTEROLAEMIC AND HYPERLIPAEMIC SUBJECTS. - PubMed - NCBI
    Farewell to androsterone in atromid -- 4 (2): 8 -- DTB - Drug and Therapeutics Bulletin

    Atromid containing androsterone was widely used until the late 1960s when the pharmaceutical industry started lobbying for its gradual retirement and its replacement with newer and more toxic drugs for cholesterol management. While that fact alone should be enough to get people interested in androsterone, what is even more important and highly relevant in light of Ray's writing about cholesterol is exactly HOW androsterone achieve its cholesterol lowering effects. The news drugs for lowering cholesterol all inhibit cholesterol synthesis through one pathway or another. But androsterone is different and just before it was relegated into oblivion, a few scientists managed to work out its mechanism of action - i.e. androsterone was a thyroid-mimetic. It increased oxygen consumpion, basal temperatures, and donwstream metabolism of cholesterol into other steroids. The same effect was observed with thyroxine (T4) treatment. So, maybe androsterone can have a second chance as a legal, OTC thyroid-mimetic with virtually no known wide effects??

    The androsterone-etiocholanolone excretion ratio in hyper- and hypothyroidism. - PubMed - NCBI
    Thyroid-androgen interrelations and the hypocholesteremic effect of androsterone. - PubMed - NCBI
    “…From these results the hypothesis was made that some of the peripheral manifestations of excess or deficit of thyroid hormone might be mediated by the metabolites of steroid androgens. In confirmation, it was found that androsterone caused a significant decrease of the serum cholesterol level in myxedematous patients, in subjects with hypercholesterolemia of varied origin, and in normocholesteremic subjects. One myxedematous patient showed an increase in basal oxygen consumption during treatment with androsterone.”

    http://press.endocrine.org/doi/abs/10.1210/jcem-21-10-1208
    “…A possible explanation for the hypocholesterolemic effect of androsterone administered intramuscularly is the conversion of a small fraction of the androsterone to an estrogen. That this is not the case is suggested by the fact that serum phospholipid levels decreased and a lipoprotein cholesterol levels remained unchanged during intramuscular androsterone therapy, whereas during estrogen therapy there was a marked increase in the level of both phospholipids and α-lipoprotein cholesterol. However, the observed lipid effects of androsterone intramuscularly were indeed "thyromimetic," in that not only did the concentration of serum cholesterol decrease, but that of phospholipids fell to a lesser extent, while the lipoprotein effect was primarily a decrease in the β-fraction. Similar effects of L-triiodothyronine (11) and L-thyroxine (12) have been reported by Oliver and Boyd.”

    The Influence of Dextro-thyroxine and Androsterone on Blood Clotting Factors and Serum Cholesterol in Patients with Atherosclerosis
    “…Our studies established a direct correlation between the atherosclerotic process and thrombotic tendencies which are the major causes of cardiovascular diseases and deaths at the present time. Whether the effects of dextro-thyroxine or androsterone on coagulation are due to the decrease in blood lipids or due to a direct action of the drug per se remains to be explained. It would be of great interest to study the changes in the plasma cephalins (phosphatidyl, ethanolamine and phosphatidyl serine) in atherosclerotic subjects receiving dextro-thyroxine or androsterone. Such a study is actually under way in our laboratory. Androsterone administered intramuscularly definitely has a "thyromimetic" effect on cholesterol level and blood coagulation.”
     
  2. paymanz

    paymanz Member

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  3. OP
    haidut

    haidut Member

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    Te clofibrate is what replaced the original Atromid formulation. The original one was just androsterone and some kind of phospholipid to enhance oral bioavailability. I don't know much about clofibrate or whether it is beneficial.
     
  4. johnwester130

    johnwester130 Member

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    "saw palmetto remedy for prostate enlargement has been reported to contain pregnenolone, or something similar to it."

    Prostate Cancer

    Is peat referring to beta sitosterol ?
     
  5. johnwester130

    johnwester130 Member

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    Is lower cholesterol a good thing ?

    This drops cholesterol by 50% ???
     
  6. OP
    haidut

    haidut Member

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    It lowers it since it acts like thyroid - so it forced the conversion of cholesterol into downstream steroids and bile acids. Other strondrogens like DHT or androstanedione also have cholesterol lowering effects. T does have them to a degree as well but if you take too much it may raise cholesterol. DHEA in low doses also lowers cholesterol but in higher ones raises it due to aromatization, just like T.
    That is the proper way to lower cholesterol, as that's how thyroid works. The statin work by inhibiting cholesterol synthesis, which is a horrible thing usually.
     
  7. Lokzo

    Lokzo Member

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    Has no one mentioned Celery here!?
     
  8. OP
    haidut

    haidut Member

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    Celery does not contain androsteRone. It contains androsteNone, a structurally similar steroid but with very different properties.
    Androstenone - Wikipedia
     
  9. Lokzo

    Lokzo Member

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    Okay thanks for the clarification there man! ✅
     
  10. Lokzo

    Lokzo Member

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    Hold your horses!!!

    It DOES contain Androsterone.

    http://chem.ubbcluj.ro/~studiachemia/issues/chemia2016_3/tom2/12_Simedru_etal_415_422.pdf

    It was proven so far that celery contains compounds such as: phalides, coumarrins [4], fatty acids [5], folate, potassium, molybdenum, small amounts of vitamin C, vitamin A and some B vitamins, flavonols and flavone antioxidants, androsterone [6, 7] and androstenol [6], which have many health benefits.
     
  11. Lokzo

    Lokzo Member

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    Because when I have MASSIVE amounts of Celery, my breathing becomes deeper, my appetite goes through the roof, and well, my loads are definitely bigger.
    Also get many of the other DHT-like effects.
     
  12. OP
    haidut

    haidut Member

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    Not really, the study itself says that.
    "...The developed method was used to test the content of androsterone from three varieties of celery acquired from a Romanian market. The results show that the investigated celery varieties have very low content of androsterone."

    AndrosteNone is the main pheromone in celery. Any living organism that reproduces sexually will probably contain minute amounts of steroids like androsterone, T, rpogesterone, etc but that does not mean these amounts are high enough to be meaningful as food sources. However, it has been shown that eating celery increases androsteNone in human sweat, so the amounts present in celery are big enough to make a difference.
     
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