The Association Of Sex Steroid Hormone Concentrations With Non-alcoholic Fatty Liver Disease And Liv

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The association of sex steroid hormone concentrations with non-alcoholic fatty liver disease and liver enzymes in US men - PubMed


Abstract
Background & aims: This study aimed to analyse the association of sex hormone levels with liver enzyme levels and non-alcoholic fatty liver disease (NAFLD) in a nationally representative sample of men.

Methods: 919 men from the US National Health and Nutrition Examination Study (NHANES) III were included in this cross-sectional analysis of data from 1988-1991. We used existing data on serum total and free testosterone, total and free estradiol, androstanediol glucuronide (AAG), sex steroid binding globulin (SHBG), and estimated their associations with aspartate aminotransferase (AST), and alanine aminotransferase (ALT) and NAFLD, as determined using ultrasound, after adjusting for possible confounders including age, race, smoking, alcohol, physical activity, waist circumference and steroid hormones.

Results: Lower total testosterone and higher free estradiol were associated with higher odds of NAFLD after adjusting for confounders including the other sex hormones. Lower total testosterone was associated with higher odds of elevated AST, but not ALT. Free testosterone, total estradiol, SHBG and AAG were not associated with NAFLD or liver enzymes.

Conclusions: This study supports an inverse association between total testosterone concentration and NAFLD in men independent of other sex hormones (SHBG, AAG, estradiol) and known risk factors such as obesity, age and lifestyle. Exploration of whether total testosterone might be a non-invasive marker for NAFLD diagnosis is warranted.
 
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