• tca300: I understand this is off topic from what you typically teach, but I was wondering if you have run across any information or learned on your own, things that help people grieve over lost loved ones, and or fear of losing others to death? Thank you!

    Ray Peat: It activates the “helplessness” reactions in the body, stress weakening your own life, and I think it can help to get out of that if you think of your life as a continuation of theirs—the same life, though with fewer bodies.

    Rest in Paradise, Raymond Peat  October 12, 1936 - November 24 2022

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Lower Androgens And/or Increase In Pituitary Hormones Linked To Increased Mortality In Men


Mar 18, 2013
USA / Europe
So much for T and DHT being bad for older men. More specifically, lower androgen levels and higher pituitary hormone levels were linked to higher cancer and CVD mortality.

Temporal changes in sex hormones linked to increased mortality in older men

"...Increased risk for all-cause mortality was associated with progressive declines in serum testosterone (RR = 1.18 per 1 standard deviation [SD] decline; 95% CI, 1.05-1.32), dihydrotestosterone (RR = 1.17 per 1 SD decline; 95% CI, 1.05-1.32), calculated free testosterone (RR = 1.27 per 1 SD decline; 95% CI, 1.13-1.41) and estradiol (RR = 1.46 per 1 SD decline; 95% CI, 1.3-1.63). A lower risk for all-cause mortality was seen with declining sex hormone-binding globulin (RR = 0.8 per 1 SD decline; 95% CI, 0.73-0.88), luteinizing hormone (LH; RR = 0.81 per 1 SD decline; 95% CI, 0.77-0.89) and follicle-stimulating hormone (FSH; RR = 0.85 per 1 SD decline; 95% CI, 0.77-0.94). Significant interactions were found between all-cause mortality and serum testosterone and serum estradiol levels (P = .02). Compared with intermediate/high testosterone and estradiol, combined low testosterone and low estradiol were linked to an increased risk for all-cause mortality (RR = 1.35; 95% CI, 1.06-1.72). Progressive declines in serum testosterone, dihydrotestosterone, calculated free testosterone, estradiol and LH/testosterone were linked to cancer-specific mortality, whereas SHBG, LH and FSH were not. Increased risk for cardiovascular-specific mortality was linked to declining serum testosterone, dihydrotestosterone, calculated free testosterone and estradiol, as well as increasing SHBG, LH, FSH and LH/testosterone."


Jul 13, 2014
so high SHBG is a bad thing?

and testosterone replacement therapy possibly a good thing...?

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