PSA: Change in Energin formulation (thiamine replaced by prosultiamine)

[haidut]

Just a quick heads up. We changed the vitamin B1 in Energin from the thiamine Hcl to the lipophilic analog known as prosultiamine. The latter is an analog of allithiamine, and allithiamine is well-known to forum users for its high bioavailability and ability to raise levels of thiamine pyrophosphate (TPP) in muscles, brains, and other organs while the same has not been shown to occur with intake of thiamin Hcl. TPP is also a required co-factor of the enzyme pyruvate dehydrogenase (PDH), which is the rate-limiting step in the oxidative metabolism of glucose. PDH downregulation has been observed in many diseases including diabetes, obesity, cancer, dementia, MELAS, ALS, myopathies, mental disorders, infectious diseases, sepsis, etc.

Prosultiamine - Wikipedia

en.wikipedia.org

Allithiamine - Wikipedia

en.wikipedia.org

Absorption, utilization and clinical effectiveness of allithiamines compared to water-soluble thiamines - PubMed

Oral administration of lipid-soluble allithiamines [thiamine propyl disulfide (TPD) and thiamine tetrahydrofurfuryl disulfide (TTHF)] rapidly increased thiamine activity in whole blood, red blood cells, cerebrospinal fluid, and urine in normal and thiamine-deficient subjects. These thiamine...

pubmed.ncbi.nlm.nih.gov

There are multiple studies on allithiamine posted on the forum and I have posted below some on prosultiamine as well. As such, the presence of porsultiamine in Energin should increase the effects associated with usage of vitamin B1. Both prosultiamine and allithiamine are naturally occurring analogs of vitamin B1, and present in high concentrations in garlic and are probably responsible for the unique smell of garlic, with Energin now smelling somewhat similar to garlic as well.

https://www.aimspress.com/fileOther/PDF/biophysics/biophy-07-01-002.pdf

Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis - PubMed

The changes in urodynamic parameters and urine levels of overactive bladder-related markers suggest that oral prosultiamine is a safe and effective treatment for overactive bladder with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis.

pubmed.ncbi.nlm.nih.gov

Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial - PubMed

University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) number, UMIN000005969. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/183.

pubmed.ncbi.nlm.nih.gov

Therapeutic benefits of an oral vitamin B1 derivative for human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) - PubMed

Prosultiamine, a vitamin B1 derivative, has long been used for beriberi neuropathy and Wernicke's encephalopathy. Based on the finding that prosultiamine induces apoptosis in human T lymphotropic virus type I (HTLV-I)-infected T cells, Nakamura et al. conducted a clinical trial of prosultiamine...

pubmed.ncbi.nlm.nih.gov

Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis - PubMed

Our results suggest that prosultiamine has the potential to be a new therapeutic tool that targets HTLV-I-infected cells in HAM/TSP.

pubmed.ncbi.nlm.nih.gov

The attempted enrichment of beer with thiamine alkyl disulphides - PubMed

The Wernicke-Korsakoff syndrome, commonplace in Australia, might be prevented by the enrichment of alcoholic beverages with thiamine. The use of the well absorbed thiamine alkyl disulphides for the enrichment of the most relevant Australian beverage, namely beer, is examined. A liquid...

pubmed.ncbi.nlm.nih.gov

Oral treatment of polioencephalomalacia and subclinical thiamine deficiency with thiamine propyl disulphide and thiamine hydrochloride - PubMed

Thiaminase type I production by Bacillus thiaminolyticus and activity in vitro were repressed by the primary substate thiamine and by thiamine monophosphate and thiamine propyl disulphide. At thiamine concentrations of 300-3000 mumol/l production of active enzyme by B. thiaminolyticus, and...

pubmed.ncbi.nlm.nih.gov

Hemodynamic response of the frontal cortex elicited by intravenous thiamine propyldisulphide administration - PubMed

The intravenous olfaction (IVO) test is a unique type of clinical olfactometry and is widely used in Japan. However, it is difficult to distinguish actual olfactory disturbance from feigned disturbance because the IVO test is a psychophysical test. To resolve this problem, we investigated the...

pubmed.ncbi.nlm.nih.gov

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO ORGANS - PubMed

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO ORGANS

pubmed.ncbi.nlm.nih.gov

PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES. I. COMPARISON OF THIAMINE PROPYL DISULFIDE AND THIOTHIAMINE - PubMed

PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES. I. COMPARISON OF THIAMINE PROPYL DISULFIDE AND THIOTHIAMINE

pubmed.ncbi.nlm.nih.gov

Measurement of urinary thiamine propyl disulfide metabolites as an index of liver function - PubMed

Thiamine propyl disulfide (TPD) was orally administered in patients with liver disease to measure the main metabolite, 2-hydroxypropyl methyl sulfone (2HPMS), in urine, for the test of liver function. The amount of urinary excretion of 2HPMS decreased in proportion to the degree of severity of...

pubmed.ncbi.nlm.nih.gov

[Methods of treatment of juvenile myopia. 1. Use of massive doses of thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide] - PubMed

[Methods of treatment of juvenile myopia. 1. Use of massive doses of thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide]

pubmed.ncbi.nlm.nih.gov

[INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE (TPS) STUDIED "IN VIVO" IN THE RAT] - PubMed

[INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE (TPS) STUDIED "IN VIVO" IN THE RAT]

pubmed.ncbi.nlm.nih.gov

[Preparation of thiamine derivative-protein complexes] - PubMed

The formation of a thiamine -- egg albumin complex through the action of thiamine propylidsulphide on native, heat denatured and iodine oxidized albumin was studied. The reaction was carried out at pH 6 to 10, temperature 20 degrees to 45 degrees C, and with varying proportions of substrates in...

pubmed.ncbi.nlm.nih.gov

Determination of urinary metabolites of thiamine propyl disulfide in humans - PubMed

Gas chromatographic procedure for the quantitative determination of methyl propyl sulfone (MPS), 2-hydroxypropyl methyl sulfone (2HPMS) and 3-hydroxypropyl methyl sulfone (3HPMS) in urine was developed. By using this procedure, the urinary excretion of MPS, 2HPMS and 3HPMS after oral dose of...

pubmed.ncbi.nlm.nih.gov

Effectiveness of alinamin for streptomycin poisoned children - PubMed

Effectiveness of alinamin for streptomycin poisoned children

pubmed.ncbi.nlm.nih.gov

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD - PubMed

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD

pubmed.ncbi.nlm.nih.gov

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine - PubMed

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine

pubmed.ncbi.nlm.nih.gov

Decreased urinary excretion of thiamine propyl disulfide metabolites in patients with liver disease - PubMed

Decreased urinary excretion of thiamine propyl disulfide metabolites in patients with liver disease

pubmed.ncbi.nlm.nih.gov

[Effect of Contol on nocturnal enuresis: especially combined therapy of Contol and Alinamin] - PubMed

[Effect of Contol on nocturnal enuresis: especially combined therapy of Contol and Alinamin]

pubmed.ncbi.nlm.nih.gov

 

[Regina]

Just a quick heads up. We changed the vitamin B1 in Energin from the thiamine Hcl to the lipophilic analog known as prosultiamine. The latter is an analog of allithiamine, and allithiamine is well-known to forum users for its high bioavailability and ability to raise levels of thiamine pyrophosphate (TPP) in muscles, brains, and other organs while the same has not been shown to occur with intake of thiamin Hcl.

Prosultiamine - Wikipedia

en.wikipedia.org

Allithiamine - Wikipedia

en.wikipedia.org

There are multiple studies on allithiamine posted on the forum and I have posted below some on prosultiamine as well. As such, the presence of porsultiamine in Energin should increase the effects associated with usage of vitamin B1. Both prosultiamine and allithiamine are naturally occurring analogs of vitamin B1, and present in high concentrations in garlic and are probably responsible for the unique smell of garlic, with Energin now smelling somewhat similar to garlic as well.

Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis - PubMed

The changes in urodynamic parameters and urine levels of overactive bladder-related markers suggest that oral prosultiamine is a safe and effective treatment for overactive bladder with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis.

pubmed.ncbi.nlm.nih.gov

Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial - PubMed

University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) number, UMIN000005969. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/183.

pubmed.ncbi.nlm.nih.gov

Therapeutic benefits of an oral vitamin B1 derivative for human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) - PubMed

Prosultiamine, a vitamin B1 derivative, has long been used for beriberi neuropathy and Wernicke's encephalopathy. Based on the finding that prosultiamine induces apoptosis in human T lymphotropic virus type I (HTLV-I)-infected T cells, Nakamura et al. conducted a clinical trial of prosultiamine...

pubmed.ncbi.nlm.nih.gov

Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis - PubMed

Our results suggest that prosultiamine has the potential to be a new therapeutic tool that targets HTLV-I-infected cells in HAM/TSP.

pubmed.ncbi.nlm.nih.gov

The attempted enrichment of beer with thiamine alkyl disulphides - PubMed

The Wernicke-Korsakoff syndrome, commonplace in Australia, might be prevented by the enrichment of alcoholic beverages with thiamine. The use of the well absorbed thiamine alkyl disulphides for the enrichment of the most relevant Australian beverage, namely beer, is examined. A liquid...

pubmed.ncbi.nlm.nih.gov

Oral treatment of polioencephalomalacia and subclinical thiamine deficiency with thiamine propyl disulphide and thiamine hydrochloride - PubMed

Thiaminase type I production by Bacillus thiaminolyticus and activity in vitro were repressed by the primary substate thiamine and by thiamine monophosphate and thiamine propyl disulphide. At thiamine concentrations of 300-3000 mumol/l production of active enzyme by B. thiaminolyticus, and...

pubmed.ncbi.nlm.nih.gov

Hemodynamic response of the frontal cortex elicited by intravenous thiamine propyldisulphide administration - PubMed

The intravenous olfaction (IVO) test is a unique type of clinical olfactometry and is widely used in Japan. However, it is difficult to distinguish actual olfactory disturbance from feigned disturbance because the IVO test is a psychophysical test. To resolve this problem, we investigated the...

pubmed.ncbi.nlm.nih.gov

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO ORGANS - PubMed

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO ORGANS

pubmed.ncbi.nlm.nih.gov

PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES. I. COMPARISON OF THIAMINE PROPYL DISULFIDE AND THIOTHIAMINE - PubMed

PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES. I. COMPARISON OF THIAMINE PROPYL DISULFIDE AND THIOTHIAMINE

pubmed.ncbi.nlm.nih.gov

Measurement of urinary thiamine propyl disulfide metabolites as an index of liver function - PubMed

Thiamine propyl disulfide (TPD) was orally administered in patients with liver disease to measure the main metabolite, 2-hydroxypropyl methyl sulfone (2HPMS), in urine, for the test of liver function. The amount of urinary excretion of 2HPMS decreased in proportion to the degree of severity of...

pubmed.ncbi.nlm.nih.gov

[Methods of treatment of juvenile myopia. 1. Use of massive doses of thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide] - PubMed

[Methods of treatment of juvenile myopia. 1. Use of massive doses of thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide]

pubmed.ncbi.nlm.nih.gov

[INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE (TPS) STUDIED "IN VIVO" IN THE RAT] - PubMed

[INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE (TPS) STUDIED "IN VIVO" IN THE RAT]

pubmed.ncbi.nlm.nih.gov

[Preparation of thiamine derivative-protein complexes] - PubMed

The formation of a thiamine -- egg albumin complex through the action of thiamine propylidsulphide on native, heat denatured and iodine oxidized albumin was studied. The reaction was carried out at pH 6 to 10, temperature 20 degrees to 45 degrees C, and with varying proportions of substrates in...

pubmed.ncbi.nlm.nih.gov

Determination of urinary metabolites of thiamine propyl disulfide in humans - PubMed

Gas chromatographic procedure for the quantitative determination of methyl propyl sulfone (MPS), 2-hydroxypropyl methyl sulfone (2HPMS) and 3-hydroxypropyl methyl sulfone (3HPMS) in urine was developed. By using this procedure, the urinary excretion of MPS, 2HPMS and 3HPMS after oral dose of...

pubmed.ncbi.nlm.nih.gov

Effectiveness of alinamin for streptomycin poisoned children - PubMed

Effectiveness of alinamin for streptomycin poisoned children

pubmed.ncbi.nlm.nih.gov

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD - PubMed

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD

pubmed.ncbi.nlm.nih.gov

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine - PubMed

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine

pubmed.ncbi.nlm.nih.gov

Decreased urinary excretion of thiamine propyl disulfide metabolites in patients with liver disease - PubMed

Decreased urinary excretion of thiamine propyl disulfide metabolites in patients with liver disease

pubmed.ncbi.nlm.nih.gov

[Effect of Contol on nocturnal enuresis: especially combined therapy of Contol and Alinamin] - PubMed

[Effect of Contol on nocturnal enuresis: especially combined therapy of Contol and Alinamin]

pubmed.ncbi.nlm.nih.gov

 

[LeeLemonoil]

Good substitution, should enhance the mix

 

[Drareg]

Just a quick heads up. We changed the vitamin B1 in Energin from the thiamine Hcl to the lipophilic analog known as prosultiamine. The latter is an analog of allithiamine, and allithiamine is well-known to forum users for its high bioavailability and ability to raise levels of thiamine pyrophosphate (TPP) in muscles, brains, and other organs while the same has not been shown to occur with intake of thiamin Hcl. TPP is also a required co-factor of the enzyme pyruvate dehydrogenase (PDH), which is the rate-limiting step in the oxidative metabolism of glucose. PDH downregulation has been observed in many diseases including diabetes, obesity, cancer, dementia, MELAS, ALS, myopathies, mental disorders, infectious diseases, sepsis, etc.

Prosultiamine - Wikipedia

en.wikipedia.org

Allithiamine - Wikipedia

en.wikipedia.org

There are multiple studies on allithiamine posted on the forum and I have posted below some on prosultiamine as well. As such, the presence of porsultiamine in Energin should increase the effects associated with usage of vitamin B1. Both prosultiamine and allithiamine are naturally occurring analogs of vitamin B1, and present in high concentrations in garlic and are probably responsible for the unique smell of garlic, with Energin now smelling somewhat similar to garlic as well.

Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis - PubMed

The changes in urodynamic parameters and urine levels of overactive bladder-related markers suggest that oral prosultiamine is a safe and effective treatment for overactive bladder with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis.

pubmed.ncbi.nlm.nih.gov

Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial - PubMed

University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) number, UMIN000005969. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/183.

pubmed.ncbi.nlm.nih.gov

Therapeutic benefits of an oral vitamin B1 derivative for human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) - PubMed

Prosultiamine, a vitamin B1 derivative, has long been used for beriberi neuropathy and Wernicke's encephalopathy. Based on the finding that prosultiamine induces apoptosis in human T lymphotropic virus type I (HTLV-I)-infected T cells, Nakamura et al. conducted a clinical trial of prosultiamine...

pubmed.ncbi.nlm.nih.gov

Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis - PubMed

Our results suggest that prosultiamine has the potential to be a new therapeutic tool that targets HTLV-I-infected cells in HAM/TSP.

pubmed.ncbi.nlm.nih.gov

The attempted enrichment of beer with thiamine alkyl disulphides - PubMed

The Wernicke-Korsakoff syndrome, commonplace in Australia, might be prevented by the enrichment of alcoholic beverages with thiamine. The use of the well absorbed thiamine alkyl disulphides for the enrichment of the most relevant Australian beverage, namely beer, is examined. A liquid...

pubmed.ncbi.nlm.nih.gov

Oral treatment of polioencephalomalacia and subclinical thiamine deficiency with thiamine propyl disulphide and thiamine hydrochloride - PubMed

Thiaminase type I production by Bacillus thiaminolyticus and activity in vitro were repressed by the primary substate thiamine and by thiamine monophosphate and thiamine propyl disulphide. At thiamine concentrations of 300-3000 mumol/l production of active enzyme by B. thiaminolyticus, and...

pubmed.ncbi.nlm.nih.gov

Hemodynamic response of the frontal cortex elicited by intravenous thiamine propyldisulphide administration - PubMed

The intravenous olfaction (IVO) test is a unique type of clinical olfactometry and is widely used in Japan. However, it is difficult to distinguish actual olfactory disturbance from feigned disturbance because the IVO test is a psychophysical test. To resolve this problem, we investigated the...

pubmed.ncbi.nlm.nih.gov

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO ORGANS - PubMed

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO ORGANS

pubmed.ncbi.nlm.nih.gov

PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES. I. COMPARISON OF THIAMINE PROPYL DISULFIDE AND THIOTHIAMINE - PubMed

PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES. I. COMPARISON OF THIAMINE PROPYL DISULFIDE AND THIOTHIAMINE

pubmed.ncbi.nlm.nih.gov

Measurement of urinary thiamine propyl disulfide metabolites as an index of liver function - PubMed

Thiamine propyl disulfide (TPD) was orally administered in patients with liver disease to measure the main metabolite, 2-hydroxypropyl methyl sulfone (2HPMS), in urine, for the test of liver function. The amount of urinary excretion of 2HPMS decreased in proportion to the degree of severity of...

pubmed.ncbi.nlm.nih.gov

[Methods of treatment of juvenile myopia. 1. Use of massive doses of thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide] - PubMed

[Methods of treatment of juvenile myopia. 1. Use of massive doses of thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide]

pubmed.ncbi.nlm.nih.gov

[INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE (TPS) STUDIED "IN VIVO" IN THE RAT] - PubMed

[INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE (TPS) STUDIED "IN VIVO" IN THE RAT]

pubmed.ncbi.nlm.nih.gov

[Preparation of thiamine derivative-protein complexes] - PubMed

The formation of a thiamine -- egg albumin complex through the action of thiamine propylidsulphide on native, heat denatured and iodine oxidized albumin was studied. The reaction was carried out at pH 6 to 10, temperature 20 degrees to 45 degrees C, and with varying proportions of substrates in...

pubmed.ncbi.nlm.nih.gov

Determination of urinary metabolites of thiamine propyl disulfide in humans - PubMed

Gas chromatographic procedure for the quantitative determination of methyl propyl sulfone (MPS), 2-hydroxypropyl methyl sulfone (2HPMS) and 3-hydroxypropyl methyl sulfone (3HPMS) in urine was developed. By using this procedure, the urinary excretion of MPS, 2HPMS and 3HPMS after oral dose of...

pubmed.ncbi.nlm.nih.gov

Effectiveness of alinamin for streptomycin poisoned children - PubMed

Effectiveness of alinamin for streptomycin poisoned children

pubmed.ncbi.nlm.nih.gov

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD - PubMed

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD

pubmed.ncbi.nlm.nih.gov

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine - PubMed

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine

pubmed.ncbi.nlm.nih.gov

Decreased urinary excretion of thiamine propyl disulfide metabolites in patients with liver disease - PubMed

Decreased urinary excretion of thiamine propyl disulfide metabolites in patients with liver disease

pubmed.ncbi.nlm.nih.gov

[Effect of Contol on nocturnal enuresis: especially combined therapy of Contol and Alinamin] - PubMed

[Effect of Contol on nocturnal enuresis: especially combined therapy of Contol and Alinamin]

pubmed.ncbi.nlm.nih.gov

Is this slightly different to allithiamine?
Have you tried it on its own? I can't find it for sale online, would be interesting to try it isolated, I never noticed much from allithiamine compared to HCL, it may have been the vendor I bought it from.

 

[haidut]

Is this slightly different to allithiamine?
Have you tried it on its own? I can't find it for sale online, would be interesting to try it isolated, I never noticed much from allithiamine compared to HCL, it may have been the vendor I bought it from.

Yep, a very similar molecule to allithiamine and also found in garlic. To me it works like regular thiamine, but achieves the same effects in much smaller doses. Also, even a "small" dose of about 10mg seems to help a lot with lactic acid building after exercise, while even 500mg thiamine Hcl have only a minor effect on that. The nootropic effects also seem to be stronger - i.e. memory is improved even after 10mg and I suddenly start remembering things from decades ago and reading a text can be done very fast and still get the gist of it despite just glancing at the words and not carefully reading them. IMO, the most important effects is the elevation of TPP after the usage of the lipophilic thiamine analogs, which did not seem to happen with thiamin Hcl, at least not at the doses used on the studies (HED ~8mg/kg). TPP did rise a bit after thiamine Hcl but the studies claims it was not statistically significant.

 

[CaptJim]

How long does the garlic like smell last?

 

[koky]

Just a quick heads up. We changed the vitamin B1 in Energin from the thiamine Hcl to the lipophilic analog known as prosultiamine. The latter is an analog of allithiamine, and allithiamine is well-known to forum users for its high bioavailability and ability to raise levels of thiamine pyrophosphate (TPP) in muscles, brains, and other organs while the same has not been shown to occur with intake of thiamin Hcl. TPP is also a required co-factor of the enzyme pyruvate dehydrogenase (PDH), which is the rate-limiting step in the oxidative metabolism of glucose. PDH downregulation has been observed in many diseases including diabetes, obesity, cancer, dementia, MELAS, ALS, myopathies, mental disorders, infectious diseases, sepsis, etc.

Prosultiamine - Wikipedia

en.wikipedia.org

Allithiamine - Wikipedia

en.wikipedia.org

There are multiple studies on allithiamine posted on the forum and I have posted below some on prosultiamine as well. As such, the presence of porsultiamine in Energin should increase the effects associated with usage of vitamin B1. Both prosultiamine and allithiamine are naturally occurring analogs of vitamin B1, and present in high concentrations in garlic and are probably responsible for the unique smell of garlic, with Energin now smelling somewhat similar to garlic as well.

Prosultiamine for treatment of lower urinary tract dysfunction accompanied by human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis - PubMed

The changes in urodynamic parameters and urine levels of overactive bladder-related markers suggest that oral prosultiamine is a safe and effective treatment for overactive bladder with human T-lymphotropic virus type 1-associated myelopathy/tropical spastic paraparesis.

pubmed.ncbi.nlm.nih.gov

Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial - PubMed

University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR) number, UMIN000005969. Please see related commentary: http://www.biomedcentral.com/1741-7015/11/183.

pubmed.ncbi.nlm.nih.gov

Therapeutic benefits of an oral vitamin B1 derivative for human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) - PubMed

Prosultiamine, a vitamin B1 derivative, has long been used for beriberi neuropathy and Wernicke's encephalopathy. Based on the finding that prosultiamine induces apoptosis in human T lymphotropic virus type I (HTLV-I)-infected T cells, Nakamura et al. conducted a clinical trial of prosultiamine...

pubmed.ncbi.nlm.nih.gov

Disulfide-mediated apoptosis of human T-lymphotrophc virus type-I (HTLV-I)-infected cells in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis - PubMed

Our results suggest that prosultiamine has the potential to be a new therapeutic tool that targets HTLV-I-infected cells in HAM/TSP.

pubmed.ncbi.nlm.nih.gov

The attempted enrichment of beer with thiamine alkyl disulphides - PubMed

The Wernicke-Korsakoff syndrome, commonplace in Australia, might be prevented by the enrichment of alcoholic beverages with thiamine. The use of the well absorbed thiamine alkyl disulphides for the enrichment of the most relevant Australian beverage, namely beer, is examined. A liquid...

pubmed.ncbi.nlm.nih.gov

Oral treatment of polioencephalomalacia and subclinical thiamine deficiency with thiamine propyl disulphide and thiamine hydrochloride - PubMed

Thiaminase type I production by Bacillus thiaminolyticus and activity in vitro were repressed by the primary substate thiamine and by thiamine monophosphate and thiamine propyl disulphide. At thiamine concentrations of 300-3000 mumol/l production of active enzyme by B. thiaminolyticus, and...

pubmed.ncbi.nlm.nih.gov

Hemodynamic response of the frontal cortex elicited by intravenous thiamine propyldisulphide administration - PubMed

The intravenous olfaction (IVO) test is a unique type of clinical olfactometry and is widely used in Japan. However, it is difficult to distinguish actual olfactory disturbance from feigned disturbance because the IVO test is a psychophysical test. To resolve this problem, we investigated the...

pubmed.ncbi.nlm.nih.gov

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO ORGANS - PubMed

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO ORGANS

pubmed.ncbi.nlm.nih.gov

PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES. I. COMPARISON OF THIAMINE PROPYL DISULFIDE AND THIOTHIAMINE - PubMed

PENETRATION OF MODIFIED THIAMINE COMPOUNDS INTO ERYTHROCYTES. I. COMPARISON OF THIAMINE PROPYL DISULFIDE AND THIOTHIAMINE

pubmed.ncbi.nlm.nih.gov

Measurement of urinary thiamine propyl disulfide metabolites as an index of liver function - PubMed

Thiamine propyl disulfide (TPD) was orally administered in patients with liver disease to measure the main metabolite, 2-hydroxypropyl methyl sulfone (2HPMS), in urine, for the test of liver function. The amount of urinary excretion of 2HPMS decreased in proportion to the degree of severity of...

pubmed.ncbi.nlm.nih.gov

[Methods of treatment of juvenile myopia. 1. Use of massive doses of thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide] - PubMed

[Methods of treatment of juvenile myopia. 1. Use of massive doses of thiamine propyl disulfide and thiamine tetrahydrofurfuryl disulfide]

pubmed.ncbi.nlm.nih.gov

[INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE (TPS) STUDIED "IN VIVO" IN THE RAT] - PubMed

[INTESTINAL ABSORPTION OF THIAMINE PROPYLDISULFIDE (TPS) STUDIED "IN VIVO" IN THE RAT]

pubmed.ncbi.nlm.nih.gov

[Preparation of thiamine derivative-protein complexes] - PubMed

The formation of a thiamine -- egg albumin complex through the action of thiamine propylidsulphide on native, heat denatured and iodine oxidized albumin was studied. The reaction was carried out at pH 6 to 10, temperature 20 degrees to 45 degrees C, and with varying proportions of substrates in...

pubmed.ncbi.nlm.nih.gov

Determination of urinary metabolites of thiamine propyl disulfide in humans - PubMed

Gas chromatographic procedure for the quantitative determination of methyl propyl sulfone (MPS), 2-hydroxypropyl methyl sulfone (2HPMS) and 3-hydroxypropyl methyl sulfone (3HPMS) in urine was developed. By using this procedure, the urinary excretion of MPS, 2HPMS and 3HPMS after oral dose of...

pubmed.ncbi.nlm.nih.gov

Effectiveness of alinamin for streptomycin poisoned children - PubMed

Effectiveness of alinamin for streptomycin poisoned children

pubmed.ncbi.nlm.nih.gov

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD - PubMed

AFFINITY OF THIAMINE PROPYL DISULFIDE-S35 TO BLOOD

pubmed.ncbi.nlm.nih.gov

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine - PubMed

Altered thiamine propyl disulfide metabolism in rats with liver injury induced by carbon tetrachloride and D-galactosamine

pubmed.ncbi.nlm.nih.gov

Decreased urinary excretion of thiamine propyl disulfide metabolites in patients with liver disease - PubMed

Decreased urinary excretion of thiamine propyl disulfide metabolites in patients with liver disease

pubmed.ncbi.nlm.nih.gov

[Effect of Contol on nocturnal enuresis: especially combined therapy of Contol and Alinamin] - PubMed

[Effect of Contol on nocturnal enuresis: especially combined therapy of Contol and Alinamin]

pubmed.ncbi.nlm.nih.gov

how can we find it on its own?

 

[haidut]

How long does the garlic like smell last?

At the 20-25 drops dose, it seems to last about an hour, but I think that is subjective to how strong a sense of smell other people around you have. The smell does not seem to be stronger than when using other sulfur-containing compounds such as taurine or DMSO.

 

[haidut]

how can we find it on its own?

If you search around on Google you can probably find it in small amounts, but most vendors won't sell it in bulk unless you are willing to sign a long-term contract for a bulk supply.

 

[koky]

If you search around on Google you can probably find it in small amounts, but most vendors won't sell it in bulk unless you are willing to sign a long-term contract for a bulk supply.

do these fit the bill?

 

[haidut]

do these fit the bill?
View attachment 43867View attachment 43868

It contains allithiamine, not prosultiamine, but it should be pretty similar in terms of effects.

 

[imcoconut]

Would you ever consider selling the prosultiamine as a standalone product? Thiamine has a very strong "nootropic"/anit-adhd effect - way stronger than anything else I've tried. Unfortunately some of the other bs in energin dont agree with me. I've tried b2, b6, b9, b12 individually, in many forms, including methylated and unmethylated variants, and they all disturb my sleep and can cause mood problems. b1, b3 (niacinamide form), b5 all provide only benefits. Anecdotally it does seem like there are a lot of other people that also have problem with those bs - and some have problems with one form, but are helped tremendously by another. Very strange.

Just thinking out loud - I haven't tried oxidal, but have tried MB, caffeine in larger doses, and not aspirin (not salyclic acid but maybe close after it's metabolized?) and they do also have nootropic effects. If prosultiamine it were added to oxidal it might synergize with them. Also ulitmately the thiamine does help support oxygenation right?

 

[Lee Simeon]

Yep, a very similar molecule to allithiamine and also found in garlic. To me it works like regular thiamine, but achieves the same effects in much smaller doses. Also, even a "small" dose of about 10mg seems to help a lot with lactic acid building after exercise, while even 500mg thiamine Hcl have only a minor effect on that. The nootropic effects also seem to be stronger - i.e. memory is improved even after 10mg and I suddenly start remembering things from decades ago and reading a text can be done very fast and still get the gist of it despite just glancing at the words and not carefully reading them. IMO, the most important effects is the elevation of TPP after the usage of the lipophilic thiamine analogs, which did not seem to happen with thiamin Hcl, at least not at the doses used on the studies (HED ~8mg/kg). TPP did rise a bit after thiamine Hcl but the studies claims it was not statistically significant.

Very interesting stuff and I cant wait to try it! But why are there so much Prosultiamine in it though if it is so potent? Can it still be used as frequently as the earlier batch? Also concerned if it would affect the balance of all these vitamins

 

[haidut]

Very interesting stuff and I cant wait to try it! But why are there so much Prosultiamine in it though if it is so potent? Can it still be used as frequently as the earlier batch? Also concerned if it would affect the balance of all these vitamins

Good point. We will see what kind of reports we get from people and if they say the 50mg is too much then we may drop the dosage down to 25mg per serving (25 drops).

 

[dukesbobby777]

If the new addition is so potent it might nullify the absorption of the other b vitamins. Is that possible? Oh wait, that was just written (asked about) above.

Still, I think this vitamin is very important if you eat a Peat diet. A Peat diet seems to deplete B1 quite easily.

 

[haidut]

If the new addition is so potent it might nullify the absorption of the other b vitamins. Is that possible? Oh wait, that was just written (asked about) above.

Still, I think this vitamin is very important if you eat a Peat diet. A Peat diet seems to deplete B1 quite easily.

I don't think it would nullify the absorption of the other B vitamins. I am not aware of competition between the various B vitamins for absorption. Besides, the lipophilic analogs of B1 such as prosultiamine seem to absorb mostly through passive diffusion, so there is even less risk of affecting other B vitamins most of which are subject to active transport bioavailability.

 

[Smelly5]

I'd be curious to know how balanced this is with the other B Vitamins.
When taking 50mg of TTFD, I have to be very ontop of my nutrition. I've heard Peat point this out when taking high doses of Thiamine as well.

That being said, for me the TTFD removes water retention in a big way so I'm keen to see if the Prosultiamine is as effective.

 

[Murtaza]

Are Fursultiamine and Prosultiamine the same thing? thanks @haidut

 

[gabys225]

I thought I got a bad batch then came here immediately and read this. I thought I had a batch with DMSO in it or something! Or it was contaminated with some sort of sulfur like drug. Just a heads up to the folks that used energin orally on their rats, this stuff tastes NOTHING like the old energin. Don't freak out! :)

 

[tastyfood]

I second that. It's not too unpleasant though!