Omega-3 Fatty Acids Inhibit NLRP3

[Dr. B]

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation.
Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation - PubMed

NLRP3 activates the proinflammatory cytokine IL-1, and also activates caspase-1, this results in the progression of many (most?) diseases. Cholesterol crystals activate NLRP3 when they are oxidized (estrogen probably plays a role in this, as well as other forms of stress).

Example of NLRP3 in disease :
http://www.nature.com/nature/journal/va ... bal=remove

"Nlrp3−/− or Casp1−/− mice carrying mutations associated with familial Alzheimer’s disease were largely protected from loss of spatial memory and other sequelae associated with Alzheimer’s disease, and demonstrated reduced brain caspase-1 and interleukin-1β activation as well as enhanced amyloid-β clearance."

I think if you're gonna eat 4g of Pufas, it might as well be Omega-3's (and using Vit E/aspirin would probably prevent prostaglandin production).

The additional strategy is to increase the anti-inflammatory cytokine IL-10, which downregulates NLRP3. Pregnenolone/Dhea/Progesterone, adiponectin, testosterone, Hdac inhibitors, Butyrate, ethanol (also inhibit NLRP3), sun light, exercise, Cayenne pepper, Nad+, cAMP, increase IL-10.

Do you even need to worry about any efa omega stuff if you just drink 64g fat from grass fed whole milk it should cover all omega needs?

 

[yerrag]

Do you even need to worry about any efa omega stuff if you just drink 64g fat from grass fed whole milk it should cover all omega needs?

why do want to cover all your omega needs? Omega 3 and omega 6 are not essential. and the body makes omega 9 ad mead acid from sugar.