Doludolu
Member
- Joined
- Dec 6, 2016
- Messages
- 149
"Of course, if you're steeped in the health sector, you may be aware of the argument that “omega-3 fatty acids, including fish oil, oxidizes within the heat of the human body”. Sure, as you can see in page 22 of this European Food Safety Authority document on fish oil, some oxidation and free radical formation will certainly occur as fish oil oxidizes in human tissue (or fish tissue) or any other raw tissue. But guess what? Small amounts of free radicals serve as crucial signaling molecules used to fight inflammation in your body, and we are talking about completely natural production in your body produced in limited amounts due to natural lipoxygenase activity, which is far, far different than the rampant oxidation that occurs via the consumption of, say, a heated and processed vegetable oil. As a matter of fact, the guy that champions the “fish oil is bad for you because it is oxidized in the body” – Brian Peskin – often cites this scientific paper to back up his “fish oil is bad for you” argument. But read the freakin' paper! It clearly states that fish oil can be oxidized in tissue but that the beneficial effects of omega-3 fatty acids may be explained by a PPAR alpha-mediated anti-inflammatory effect of oxidized EPA. Folks like Brian simply confuse the difference between peroxidation, which is the oxidative degradation of lipids in which free radicals “steal” electrons from the lipids in cell membranes, resulting in cell damage and oxidation, a natural transfer of electrons that occurs all the time within normal human metabolism.
You can continue to read headlines of multiple additional studies regarding this, including “Inhibition of leukocyte-endothelial interactions by oxidized omega-3 fatty acids: a novel mechanism for the anti-inflammatory effects of omega-3 fatty acids in fish oil”, “Oxidized omega-3 fatty acids inhibit pro-inflammatory responses in glomerular endothelial cells“, “Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway” and “Inhibition of phagocyte-endothelium interactions by oxidized fatty acids: a natural anti-inflammatory mechanism?“. This means oxidized EPA and other omega-3 fatty acids can – inside your body – serve as a free radical signaling mechanism that shuts down inflammation, which is why human clinical trials demonstrate fish oil's efficacy for a variety of beneficial health effects related to fighting inflammation, particularly for the heart and the brain. But this doesn't mean you should consume rancid, oxidized fish oil. You instead need to consume pure, clean, unoxidized fish oil that then undergoes a natural oxidation process within your body! "
You can continue to read headlines of multiple additional studies regarding this, including “Inhibition of leukocyte-endothelial interactions by oxidized omega-3 fatty acids: a novel mechanism for the anti-inflammatory effects of omega-3 fatty acids in fish oil”, “Oxidized omega-3 fatty acids inhibit pro-inflammatory responses in glomerular endothelial cells“, “Oxidized omega-3 fatty acids inhibit NF-kappaB activation via a PPARalpha-dependent pathway” and “Inhibition of phagocyte-endothelium interactions by oxidized fatty acids: a natural anti-inflammatory mechanism?“. This means oxidized EPA and other omega-3 fatty acids can – inside your body – serve as a free radical signaling mechanism that shuts down inflammation, which is why human clinical trials demonstrate fish oil's efficacy for a variety of beneficial health effects related to fighting inflammation, particularly for the heart and the brain. But this doesn't mean you should consume rancid, oxidized fish oil. You instead need to consume pure, clean, unoxidized fish oil that then undergoes a natural oxidation process within your body! "