Lowering and Stabilizing PSA Levels in Advanced-prostate Cancer Patients With Oral Methioninase


Dec 10, 2016


Background/aim: Methionine addiction is a general and fundamental hallmark of cancer due to the excess use of methionine for transmethylation reactions, termed the "Hoffman Effect". Methionine addiction has been shown to be a highly-effective target for cancer therapy by methionine restriction with oral recombinant methioninase (o-rMETase) in preclinical studies, including patient- derived orthotopic xenograft (PDOX) mouse models of cancer. A clinical study of o-rMETase as a supplement showed a 70% reduction of PSA levels in a patient with bone-metastatic prostate cancer.
Materials and methods: In the present study, two advanced prostate-cancer patients took o-rMETase as a supplement for approximately one month.
Results: One of the patients taking o-rMETase showed a 38% reduction of PSA levels and the second patient showed a 20% PSA reduction.
Conclusion: o-rMETase shows promise for treating patients with advanced prostate cancer.
Similar threads
Thread starter Title Forum Replies Date
ecstatichamster Lowering starch and muscle meat making fat loss easy Digestion, Gut Flora 55
copycat Lowering libido. Male Issues 1
Vileplume Supplementing thyroid, heart rate lowering a TON — lowered adrenaline? Good thing? Natural Dessicated Thyroid 3
Sam321 Salt and lowering adrenaline. Ask For Help or Advice 6
Hans Coconut oil for lowering blood sugar, insulin requirements, inflammation and appetite Scientific Studies 24
P Why Does Lowering Estrogen Slow My Hair Loss? (Interesting experience) Hair & Nails 4
NodeCerebri Methylene Blue lowering nitric oxide too much? Supplements 1
T Seratonin Sydrome Being My Issues? And Lowering Seratonin Please Mental Issues 2
haidut Lowering Estrogen Prevents Memory Decline In Menopausal Females Scientific Studies 1
haidut Alcohol Causes Liver (and Other Organ) Damage By Lowering NAD/NADH Ratio Scientific Studies 0
yerrag RESPERATE-$300 BP Lowering Device - Is It Just An Easier Way To Buteyko? Heart, Heart Rate, Blood Pressure 5
november Lowering Inflammation Skin 14
J Lowering Dht Ask For Help or Advice 16
Gadreel Is Celery Seed Good For Lowering Estrogen? Ask For Help or Advice 0
P Help Lowering Cat's Liver Enzymes! Animals 15
ecstatichamster Topical Agmatine Aqueous Lowering Intraocular Pressure Eyes, Ears, Nose and Headaches/Migraines 5
J Snack/meal Ideas For Lowering Estrogen Diet 8
Hgreen56 Has Someone Positive Experience Lowering Cortisol With Caffeine? Supplements, Pharmaceutical Drugs 4
J Does Pomegranate Have An Endotoxin Lowering Effect? Beverages, Fruits, Sugars 10
Such_Umami Focus On Lowering Visceral Fat Testimonials 17
J Lowering Blood Sugar Ask For Help or Advice 12
J Blood Donations Permanently Lowering Killer T-cells Minerals 12
haidut Lowering DHT Synthesis Causes Severe Hypothyroidism, Despite Higher T Levels Scientific Studies 21
M Iron Lowering Effect Of Aspirin Ask For Help or Advice 5
GorillaHead Lowering Serum Aromatase Instead Of Tissue Aromatase? Supplements, Pharmaceutical Drugs 5
G Dry Eyes When Taking Estrogen Lowering Substances Eyes, Ears, Nose and Headaches/Migraines 21
L How To Raise Blood Sugar (Without Lowering Insulin Sensitivity)? Blood Sugar 2
A Magnesium Supplementation, Lowering Mood Ask For Help or Advice 24
Aleeri T3 Lowering Heart Rate? Supplements, Pharmaceutical Drugs 10
Ms.Orchid Relora For Lowering Cortisol/helping With Insomnia Supplements, Pharmaceutical Drugs 6
jamies33 How Long Does It Take To See The Blood-calcium Lowering Effect Of High Dietary Calcium? Blood Work, Labs 6
gilson d dantas Progesterone Lowering Serum Progesterone? Supplements, Pharmaceutical Drugs 9
K Benefits To Lowering Tsh Blood Work, Labs 5
Mito Cholesterol-lowering Drugs Tied To Reduced Glaucoma Risk Articles & Scientific Studies 0
yerrag Instead Of Lowering Blood Pressure, Why Not Increase Heart Rate Instead? Heart, Heart Rate, Blood Pressure 36
F Does Lowering Estrogen Actually Help Male Sexual Function? Sexuality 41
Peatogenic Is There A Negative Feedback Response From Lowering Estrogen? Hormones 9
P Need Advice Lowering TSH After Having Bad Reaction To Prescribed Levoxyl Male Issues 0
P Lowering Estrogen Is The Key To Skinny Legs? Weight 24
haidut The Benefits Of Fasting Are Due To Lowering Endotoxin (LPS), Not Less Calories Scientific Studies 33
haidut Artificially Lowering Blood Glucose May Cause Fatal Flesh-eating Infection Scientific Studies 12
Lokzo COROSOLIC ACID - Glucose Control, Insulin Sensitivity, Cortisol Lowering Blood Sugar 35
Captain_Coconut Help Lowering Excess Quinolinic Acid Ask For Help or Advice 4
Jerimy Brown Recipes For Lowering Serotonin (Serotonin Syndrome Recovery Diet) Recipes 78
M I Could Use Some Help On Lowering My Cholesterol Cholesterol 41
R What Happens After Prolonged Consumption Of 5a-Reductase Lowering Substances? Experiments 16
griesburner L-Valine To Lower Serotonin Without Lowering Dopamine? Amino Acids 12
biggirlkisss Lowering Fat Of Store Brought Cheese Ask For Help or Advice 4
ecstatichamster I've Felt Super Good Lately - Is It Lowering Wheat And Using Enzymes? Diet 7
N Lowering Cortisol Too Low? Disturbed Sleep Mind, Sleep, Stress 3

Similar threads