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mitochondrial dysfunction

  1. C

    Hesperetin restores youth in old rats - enhances lifespan ~8% up to ~14% when given late, restores mitochondria & metabolism, reverses heart damage

    Posting this part from a thread i wrote on Hesperidins beneficial effects on toxic metal protection, diabetes, wound healing etc Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice): *Reverses effects of aging / restores youth...
  2. 'peataphysique

    Childhood dementia claiming young lives | A Current Affair

    • 'peataphysique
    • Thread
    • alzheimer's child dementia childhood dementia endotoxin energetic deficiency industrial pollution iron mitochondrial dysfunction pollution radiation damage
    • Replies: 3
    • Forum: Children
  3. Hans

    Is aspirin harmful to the mitochondria? (a discussion of the research)

    Another great concern that people might have about aspirin is its effect on the mitochondria (the first 1 I covered was aspirin and intestinal bleeding). There is some research indicating that it might be harmful, and the last thing we would want to do is harm our mitochondria. But what's the...
  4. haidut

    Liver Disease Is Caused By Low ATP Driven By Fat (PUFA) Oxidation

    I posted a study several months ago on the ability of inosine to prevent/reverse liver disease, and how liver damage caused by various toxins was due to lower ATP levels in the liver. Inosine, being both a metabolite and precursor of ATP, is able to restore ATP levels and as such to...
    • haidut
    • Thread
    • atp cardiolipin cirrhosis fao fas fatty acid oxidation fatty acid synthesis liver liver disease mitochondrial dysfunction nafld nash peroxidation pufa
    • Replies: 25
    • Forum: Scientific Studies
  5. haidut

    Bile Acid Stimulates Mitochondrial Function, Could Treat Parkinson And Alzheimer's

    I posted a few studied some time ago showing that bile acids increase metabolism but stimulating the synthesis of T3. This increase in metabolism is perhaps the main mechanism behind the ability of "obesity surgery" to provide long-term benefits for the people who undergo the procedure. Aside...
    • haidut
    • Thread
    • alzheimer's bile acid cure metabolism mitochondria mitochondrial dysfunction neurodegenerative parkinson taurine treatment udca
    • Replies: 22
    • Forum: Scientific Studies
  6. haidut

    Serotonin Causes Bipolar Disorder (through Mitochondrial Dysfunction)

    Yet another nail in the coffin of the "happiness hormone", which may end up being one of the biggest scientific frauds of the 20th century, rivaling the one about estrogen being the "female" hormone. It has been known for a long time that both lithium and methylene blue, both of which are...
    • haidut
    • Thread
    • 5-ht bipolar disorder mental illness metabolism mitochondria mitochondrial dysfunction psychosis serotonin
    • Replies: 3
    • Forum: Scientific Studies
  7. haidut

    Androgen Deficiency As The Main Cause Of Chronic Disease In Males

    This is one of the most comprehensive reviews that I have ever come across on the topic of androgens and their role in male health. It is authored by one of the most renowned experts in urology - the former director of the Department of Urology at Boston University (BU) School of Medicine. Given...
    • haidut
    • Thread
    • aging androgen deficiency androgen deprivation cvd dht diabetes dutasteride finasteride heart attack heart disease hepatocellular carcinoma insulin resistance liver cancer liver disease males mitochondrial dysfunction nafld sexual dysfunction stroke testosterone
    • Replies: 108
    • Forum: Scientific Studies
  8. haidut

    Niacinamide And Doxycycline May Treat Alzheimer Disease (AD)

    This study is yet another one that shows benefit of raising NAD levels for treating neurodegenerative conditions like AD. There were a few older studies around 2003, which were also done on mice and as a result of those studies a human clinical trial with 3g niacinamide daily (a dose that...
    • haidut
    • Thread
    • alzheimer's cure doxycycline metabolic mitochondria mitochondrial dysfunction nad niacinamide parkinson reverse treat
    • Replies: 7
    • Forum: Scientific Studies
  9. haidut

    No Need For Mutations, Mitochondrial Stress Alone Can Trigger Cancer

    As Ray said, the official story on cancer and many other conditions thought to be genetic is slowly changing. The powers that be won't admit overnight that genetics has little (if anything) to do with cancer, but the evidence for metabolic dysfunction as a cause of cancer is slowly building up...
    • haidut
    • Thread
    • cancer dna hif hif-1 metabolic stress mitochondrial dysfunction
    • Replies: 23
    • Forum: Scientific Studies
  10. P

    Some Pentoxifylline Studies

    Pentoxifylline Reverses Oxidative Mitochondrial Defect in Claudicating Skeletal Muscle The effect of pentoxifylline on filterability of normal red blood cells and their adhesiveness to cultured endothelial cells - Springer Pentoxifylline Neuroprotective Effects Are Possibly Related to Its...
    • paymanz
    • Thread
    • antiinflammatory cardiac diabetes dopaminergic jnk mitochondria mitochondrial dysfunction neuroprotective oxidative metabolism parkinson's pentoxifylline study tnf
    • Replies: 8
    • Forum: Scientific Studies
  11. Ras

    Methylene Blue Alleviates Nuclear And Mitochondrial Abnormalities In Progeria

    From their summary: From the common press Full study About the disease
    • Ras
    • Thread
    • fibroblast methylene blue mitochondrial dysfunction progeria study
    • Replies: 7
    • Forum: Scientific Studies
  12. michael94

    Benefits Of Exercise On Mitochondrial Dysfunction And Oxidative Stress

    http://www.ncbi.nlm.nih.gov/pubmed/26503074 2015 Oct 27 mostly concerning skeletal muscle here and this was in older folk but still worth a read thoughts/comments appreciated, unfortunately the full text is behind a paywall edit: And of course, degree matters here's some additional info...
    • michael94
    • Thread
    • excercise mitochondrial dysfunction oxidative stress
    • Replies: 15
    • Forum: Exercise
  13. P

    Caffeine: Neuroprotective Against Quinolinic Acid Induced Mitochondrial Dysfunction; Huntington's

    http://www.ncbi.nlm.nih.gov/pubmed/25443748 Abstract BACKGROUND: Chronic quinolinic acid (QA) lesions in rats closely resemble Huntington's disease like conditions. Oxidative stress and mitochondrial dysfunction have long been implicated in the neurotoxic effects of QA acting through...
    • paymanz
    • Thread
    • caffeine huntington's mitochondrial dysfunction nad nad+ neuroprotective study
    • Replies: 0
    • Forum: Scientific Studies
  14. haidut

    Decline In Mitochondrial Function Is What Triggers Cancer

    According to this study, the process of mitchondrial function decline, as seen in aging, creates a state of chronic hypoxia by inducing HIF-1 (which also happens to powerfully promote cancer). In fact, the following quote form the study reads like it could have been written by Ray Peat himself...
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