mitochondrial dysfunction

  1. Philomath

    Why isn't this thread about Cocoa a bigger deal?

    "Energy and structure are interdependent at every level" -Ray Peat If the primary focus of this forum revolves around Dr. Peat's theories concerning the significance of energy production, why aren't threads like these receiving more attention...
  2. cs3000

    Hesperetin restores youth in old rats - enhances lifespan ~8% up to ~14% when given late, restores mitochondria & metabolism, reverses heart damage

    Posting this part from a thread i wrote on Hesperidins beneficial effects on toxic metal protection, diabetes, wound healing etc Great study on the life promoting effects of hesperitin (the derivative of hesperidin found in orange juice): *Reverses effects of aging / restores youth...
  3. 'peataphysique

    Childhood dementia claiming young lives | A Current Affair

  4. Hans

    Is aspirin harmful to the mitochondria? (a discussion of the research)

    Another great concern that people might have about aspirin is its effect on the mitochondria (the first 1 I covered was aspirin and intestinal bleeding). There is some research indicating that it might be harmful, and the last thing we would want to do is harm our mitochondria. But what's the...
  5. haidut

    Liver Disease Is Caused By Low ATP Driven By Fat (PUFA) Oxidation

    I posted a study several months ago on the ability of inosine to prevent/reverse liver disease, and how liver damage caused by various toxins was due to lower ATP levels in the liver. Inosine, being both a metabolite and precursor of ATP, is able to restore ATP levels and as such to...
  6. haidut

    Bile Acid Stimulates Mitochondrial Function, Could Treat Parkinson And Alzheimer's

    I posted a few studied some time ago showing that bile acids increase metabolism but stimulating the synthesis of T3. This increase in metabolism is perhaps the main mechanism behind the ability of "obesity surgery" to provide long-term benefits for the people who undergo the procedure. Aside...
  7. haidut

    Serotonin Causes Bipolar Disorder (through Mitochondrial Dysfunction)

    Yet another nail in the coffin of the "happiness hormone", which may end up being one of the biggest scientific frauds of the 20th century, rivaling the one about estrogen being the "female" hormone. It has been known for a long time that both lithium and methylene blue, both of which are...
  8. haidut

    Androgen Deficiency As The Main Cause Of Chronic Disease In Males

    This is one of the most comprehensive reviews that I have ever come across on the topic of androgens and their role in male health. It is authored by one of the most renowned experts in urology - the former director of the Department of Urology at Boston University (BU) School of Medicine. Given...
  9. haidut

    Niacinamide And Doxycycline May Treat Alzheimer Disease (AD)

    This study is yet another one that shows benefit of raising NAD levels for treating neurodegenerative conditions like AD. There were a few older studies around 2003, which were also done on mice and as a result of those studies a human clinical trial with 3g niacinamide daily (a dose that...
  10. haidut

    No Need For Mutations, Mitochondrial Stress Alone Can Trigger Cancer

    As Ray said, the official story on cancer and many other conditions thought to be genetic is slowly changing. The powers that be won't admit overnight that genetics has little (if anything) to do with cancer, but the evidence for metabolic dysfunction as a cause of cancer is slowly building up...
  11. P

    Some Pentoxifylline Studies

    Pentoxifylline Reverses Oxidative Mitochondrial Defect in Claudicating Skeletal Muscle The effect of pentoxifylline on filterability of normal red blood cells and their adhesiveness to cultured endothelial cells - Springer Pentoxifylline Neuroprotective Effects Are Possibly Related to Its...
  12. Ras

    Methylene Blue Alleviates Nuclear And Mitochondrial Abnormalities In Progeria

    From their summary: From the common press Full study About the disease
  13. michael94

    Benefits Of Exercise On Mitochondrial Dysfunction And Oxidative Stress 2015 Oct 27 mostly concerning skeletal muscle here and this was in older folk but still worth a read thoughts/comments appreciated, unfortunately the full text is behind a paywall edit: And of course, degree matters here's some additional info...
  14. P

    Caffeine: Neuroprotective Against Quinolinic Acid Induced Mitochondrial Dysfunction; Huntington's Abstract BACKGROUND: Chronic quinolinic acid (QA) lesions in rats closely resemble Huntington's disease like conditions. Oxidative stress and mitochondrial dysfunction have long been implicated in the neurotoxic effects of QA acting through...
  15. haidut

    Decline In Mitochondrial Function Is What Triggers Cancer

    According to this study, the process of mitchondrial function decline, as seen in aging, creates a state of chronic hypoxia by inducing HIF-1 (which also happens to powerfully promote cancer). In fact, the following quote form the study reads like it could have been written by Ray Peat himself...
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