Bile Acid Stimulates Mitochondrial Function, Could Treat Parkinson And Alzheimer's

Discussion in 'Scientific Studies' started by haidut, Aug 31, 2018.

  1. haidut

    haidut Member

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    I posted a few studied some time ago showing that bile acids increase metabolism but stimulating the synthesis of T3. This increase in metabolism is perhaps the main mechanism behind the ability of "obesity surgery" to provide long-term benefits for the people who undergo the procedure. Aside form surgery, several steroids like allopregnanolone and progesterone also act upon the bile acid receptor and likely have similar effects. So does taurine, as a result of increasing bile acid synthesis.
    How Taurine May Treat Diabetes
    How Pregnenolone And Progesterone Raise Metabolism

    This new study below found that one of these bile acids - ursodeoxycholic acid (UDCA) increases mitochondrial function, and as a result was beneficial for Parkinson disease (PD).
    Ursodeoxycholic acid - Wikipedia
    The authors think that the same mechanism may benefit patients with Alzheimer's disease (AD), which once again strongly suggests that both disease are metabolic in origin.

    Ursodeoxycholic Acid Improves Mitochondrial Function and Redistributes Drp1 in Fibroblasts from Patients with either Sporadic or Familial Alzheimer's Disease - ScienceDirect
    https://medicalxpress.com/news/2018-08-liver-disease-drug-cells-alzheimer.html

    "...The pioneering study, funded by Alzheimer's Research UK, discovered the drug ursodeoxycholic acid (UDCA) improves mitochondrial dysfunction – which is known to be a causative factor for both sporadic and familial Alzheimer's disease. Mitochondria play a pivotal role in both neuronal cell survival and death as they regulate energy metabolism and cell death pathways acting as a cell's battery. Mitochondrial abnormalities have been identified in many cell types in Alzheimer's disease, with deficits occurring before the development of the classical pathological aggregations. The energy changes have been found in many different cells from people with Alzheimer's. It is thought they are one of the earliest changes to occur in the brain cells, perhaps even before symptoms are reported by people living with the disease. Dr Heather Mortiboys, Parkinson's UK Senior Research Fellow at the University of Sheffield's Institute of Translational Neuroscience (SITraN), said: "For the first time in actual Alzheimer's patient tissue this study has shown that the drug UDCA acid can boost the performance of the cells' batteries, the mitochondria. "We also found that the drug, which is already in clinical use for liver disease, acts by changing the shape of the batteries which could tell us more about how other drugs can be beneficial in Alzheimer's. "Most importantly we found the drug to be active in cells from people with the most common type of the devastating disease – sporadic Alzheimer's – which could mean it has potential for thousands of patients." Dr Mortiboys, who led the study, added: "As the drug is already in clinical use for liver disease; this speeds up the potential time it could take to get this drug to the clinic for patients." The ground-breaking research also found the drug changed the shape of mitochondria by redistributing Dynamin-related protein 1 (Drp1) to the mitochondria in people with Alzheimer's skin cells. Drp1 is a regulator of mitochondrial shape and locates at the mitochondria to initiate fission events. It is thought this could have neuroprotective effects in Alzheimer's disease. This study suggests this pathway could be manipulated by drugs which are then neuroprotective in patients themselves."

    "...Previous laboratory studies conducted by SITraN in 2015 showed UDCA could be an effective treatment in halting the progression of Parkinson's disease. The collaborative study demonstrated the effects of the drug in patients that carry the LRRK2 mutation. The study showed improved mitochondrial function as demonstrated by the increase in oxygen consumption and cellular energy levels."
     
  2. ddjd

    ddjd Member

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    Taurine and glycine both essential for bile production I believe.

    Choline also has something to do with healthy bile flow.
     
  3. griesburner

    griesburner Member

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    Would the supplement "TUDCA" do the same then as the drug UDCA? I know here in germany UDCA is prescription only but you can get TUDCA as a supplement very easy. Anyone know the difference between these substances and why one is prescription only and one not? taurine i tried several times, but always had pounding heart from it dont know why so that is not an option for me (sadly as it is the cheapest :))
     
  4. stsfut

    stsfut Member

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    Could you weigh in on ox bile supplements? For someone with a gallbladder still.
     
  5. Tarmander

    Tarmander Member

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    I had some good results with TUDCA but it increased gyno for me...Taurine does that...probably LH rising.
     
  6. OP
    haidut

    haidut Member

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    Yes, it should, and in fact has been found to be superior to UDCA in several studies.
     
  7. OP
    haidut

    haidut Member

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    Should be fine. Taurine/glycine also stimulate bile production as @Joeyd mentioned. I think thyroid does too.
     
  8. OP
    haidut

    haidut Member

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    Interesting. How much were you using of each? I have never had problems with taurine in doses under 3g daily.
     
  9. nwo2012

    nwo2012 Member

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    Coffee certainly does. It could also be the fact they all stimulate the liver, cleaning out toxins that bile acids and stimulation of bile release is so beneficial.
     
  10. ecstatichamster

    ecstatichamster Member

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  11. Tarmander

    Tarmander Member

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    Iirc...and it was a long time ago, taurine did not give as much gyno as tudca...I took taurine for awhile and had good energy before gyno slowly crept in. Tudca seemed to make nips swollen after one day. Maybe like @ecstatichamster says and it raises prolactin
     
  12. Hans

    Hans Member

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    It's important to excrete that bile with something like carrot salad, as secondary bile (which is reabsorbed bile), is associated with obesity and diabetes.
     
  13. Mufasa

    Mufasa Member

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    I believe that Chris Masterjohn recommends eating fibrous food for increasing bile acid production.
     
  14. Mufasa

    Mufasa Member

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    I send this study to Ray Peat asking if eating food like carots, bamboo shoots and mushrooms may stimulate bile acid production. His answer was that they probably stimulate bile acid production in the liver but he didnt know how that would affect the amount that gets absorbed in the general circulation.
     
  15. Amazoniac

    Amazoniac Member

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  16. Mufasa

    Mufasa Member

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  17. Amazoniac

    Amazoniac Member

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  18. Motif

    Motif Member

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    I can't tolerate taurine at all unfortunately.
    My bile flow is really bad. Probably this is what made me sick.

    I surmise progesterone helps a bit with it. I started a few days ago and my stools are darker.

    But not sure if it's safe to stay on progesterone.
     
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