cytochrome c

  1. haidut

    Red Light Therapy For Parkinson Disease (PD) Begins Human Trials

    A few weeks ago, I posted about a human study demonstrating reversal of age-related vision decline by staring at a red light for just a few minutes a day. The mechanism of action proposed in that study had to do with improved mitochondrial function and energy production. Now, it seems another...
  2. haidut

    Osteoporosis Is Caused By Mitochondrial Dysfunction Driven By Nitric Oxide (NO)

    Let’s repeat the mantra one more time – structure and function cannot be separated, they are mutually dependent at every level of reality/life. As such, it is little surprise (to us) that a structural disorder like osteoporosis may be caused by a deficiency in energy production. Yet, despite...
  3. haidut

    Human Study Confirms Alzheimer As A Metabolic Condition (brain Diabetes)

    Over the last 3 years I posted quite a few studies on Alzheimer disease (AD) and have discussed it at length in the Danny Roddy podcasts. Among the most successful interventions are niacinamide and methylene blue (MB) both of which are in human clinical trials, thyroid and aspirin. Alzheimer...
  4. haidut

    Red Light Treats PTSD By Upregulating Cytochrome C And Brain Oxygenation

    The US military has been pouring a lot of money into PTSD research, and especially non-chemical treatments. The official estimates, which are likely downsized due to political concerns, are that about 25% - 30% of combat veterans suffer from some stage of PTSD. The prescribed SSRI drugs are...
  5. P

    Methylene Blue Delays Cellular Senescence And Enhances Key Mitochondrial Biochemical Pathways

    www.ncbi.nlm.nih.gov/pubmed/17928358 Abstract Methylene blue (MB) has been used clinically for about a century to treat numerous ailments. We show that MB and other diaminophenothiazines extend the life span of human IMR90 fibroblasts in tissue culture by >20 population doubling (PDLs). MB...
  6. haidut

    Aspirin increases Cytochrome C oxidase expression

    The study was in vitro and used a seemingly high dose of aspirin that cannot really be achieved in humans. But there is good news. http://ajpgi.physiology.org/content/289/4/G731.long "...Aspirin treatment caused a significant increase in cytochrome c oxidase (COX IV) expression over the basal...
  7. haidut

    Cytochrome C is a metabolic target of caffeine

    It seems that adenosine antagonism is the mechanism of action so other adenosine antagonists may be metabolically beneficial as well. http://www.ncbi.nlm.nih.gov/pubmed/18583456 "...Using mass spectroscopy, we found that Cox7c, a nuclear-encoded subunit of the mitochondrial enzyme cytochrome...
  8. haidut

    Caffeine restores cytochrome C damaged by sepsis

    Animal study and it only looked at effects of sepsis on the heart, however I do not see why the results would not apply to other organs damaged by similar methods like endotoxin (which can be considered a milder version of sepsis). Human dose would be equal to one cup of coffee or about...
  9. haidut

    More Evidence That Diseases Like ALS Are Mitochondrial

    I have posted before on this topic, including studies that show copper supplementation extends the life of ALS rodent models by boosting activity of cytochrome C. This is the latest development. When Mitochondria Don't Get Moving, Motor Neuron Disease May Develop "...Researchers led by Janet...
  10. haidut

    Caffene restores lowered cytochrome C oxidase activity

    The study was focused on the negative effects of sepsis on heart muscle, but I don't see why the effects would not apply to cytochrome C elsewhere it the body: http://www.ncbi.nlm.nih.gov/pubmed/19242342 "...Caffeine restored CcOX activity and increased left ventricular pressure and +/-dP/dt...
  11. haidut

    Copper Restores Damaged Cytochrome C Oxidase Activity

    More specifically, exogenous copper supplementation, not copper present in food. So, for those that do not fancy liver, copper supplementation maybe a viable route. Ray has said that 4oz of liver has 30mg of copper, which is our weekly requirement. So, I am taking 4mg copper gluconate daily and...
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