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More Evidence That Diseases Like ALS Are Mitochondrial

Discussion in 'Scientific Studies' started by haidut, Sep 23, 2014.

  1. haidut

    haidut Member

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    I have posted before on this topic, including studies that show copper supplementation extends the life of ALS rodent models by boosting activity of cytochrome C. This is the latest development.

    When Mitochondria Don't Get Moving, Motor Neuron Disease May Develop

    "...Researchers led by Janet Shaw, Ph.D., professor of biochemistry, found that when healthy, functioning mitochondria was prevented from moving along axons – nerve fibers that conduct electricity away from neurons – mice developed symptoms of neurodegenerative diseases. In a study in the Proceedings of the National Academy of Sciences, Shaw and her research colleagues said their findings indicate that motor neuron diseases might result from poor distribution of mitochondria along the spinal cord and axons...“The mitochondrial function in the cells appeared to be fine, and calcium levels were normal,” she says. “This shows for the first time that restricting mitochondrial movement and distribution could cause neuronal disease.”
     
  2. Suikerbuik

    Suikerbuik Member

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    Is restricted mitochondrial movement related to mitochondrial health? (authors says that the mitochondria seemed to be fine?). Or are non-mitochondrial related factors involved in mitochondrial movement?
     
  3. Brothers keeper

    Brothers keeper Member

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    The link is broken?
     
  4. OP
    haidut

    haidut Member

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    I fixed it. Thanks for pointing it out.
     
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