als

  1. Mauritio

    Serotonin, PUFA and histamine increase leaky brain

    This is just just another angle showing how stress hormones and PUFA affect the whole body negatively. Increased Blood-brain-barrier permeability(leaky brain) is linked to many diseases : "Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including...
  2. haidut

    DHT, not T, likely the "active" androgen in heart and brain

    Interesting study, done on baboons (so should have good relevance for humans), demonstrating that the cardiovascular system (CVS) exclusively accumulates and recognizes (at the receptor level) DHT, instead of testosterone (T). In fact, the androgen receptor in CVS is so structurally different it...
  3. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
  4. B

    Can Riboflavin Increase Cholesterol? Experiences With Riboflavin Please?

    I have always had very low cholesterol, and the necessity of taking thyroid meds has lowered it further. Various ways have been reported to increase cholesterol. The typically suggested methods to increase cholesterol include consuming extra cholesterol and consuming extra sugar. I found only...
  5. haidut

    Some ALS Cases May Be Cured By Vitamin B2 (riboflavin)

    A rather fascinating case study/report, which, despite its misleading and convoluted description, suggests yet again that motor neuron diseases such as Amyotropic Lateral Sclerosis (ALS) are nothing but severe mitochondrial/energetic dysfunction that can often be remediated quite easily. This is...
  6. haidut

    Niacinamide May Improve Symptoms Of ALS

    Just over a week ago I posted a thread on ALS being linked to increased fatty acid oxidation (FAO) and as such a decreased glucose availability/oxidation. ALS Tied To Increased Fat Oxidation (FAO), Increasing Glucose May Treat It Now, the study below further corroborates this FAO-disease...
  7. haidut

    ALS Tied To Increased Fat Oxidation (FAO), Increasing Glucose May Treat It

    I made a few posts in the past about ALS characterized by adrenal hyperactivity and suppressed gonadal function, as well as mitochondrial dysfunction and copper deficiency. Also, non-familial ALS is known to occurs 4-5 times more often in active/retired elite athletes. All of these findings...
  8. haidut

    Niacinamide May Treat ALS (and Stroke)

    I posted a few studies in the past demonstrating that ALS is a mitochondrial/metabolic disease and as such can be treated with pro-metabolic therapies like thyroid or copper (currently in clinical trials). This new study shows that raising NAD levels with the NAD precursor nicotinamide...
  9. haidut

    White-collar Jobs Linked To ALS And Parkinson

    Ever since ALS and Parkinson were formally introduced into the medical vocabulary, the medical industry has been trying to explain their increasing incidence with a variety of bizarre genetic stories. The genetic explanation started to collapse in the late 90s when it became evident that 90% of...
  10. haidut

    Exposure To EMF May Cause ALS

    I am posting this not so much because the link is strong but because the official message is that EMF is "completely benign" and cannot cause any disease because there is no known mechanism of action for it. That is of course a lie, and I posted a Q&A on Reddit that occurred a few years ago in...
  11. haidut

    Caffeine Protects Against Dementia (AD), ALS, Parkinson, And Huntington Disease

    The link between caffeine intake and lower risk of neurodegenerative conditions has been established before but the mechanism of action was unknown. This study discovered one possible mechanism and also confirmed the associative findings in vivo using a mouse model. The HED was 150mg - 300mg...
  12. haidut

    5α-Dihydroprogesterone (5α-DHP) - Potent Role In Neurodegenerative Conditions

    While researching saturated steroids and their effects on the brain, I noticed a number of highly promosing studies demonstrating benefit of such steroid for a variety of neurodegenerative conditions such as MS, ALS, Alzheimer, Parkinson, etc. Ray has written extensively on the topic of...
  13. M

    Endotoxin And Iron Finally Recognized As Potential Causes Of Many Diseases

    [ moderator edit: threads merged ] Bacteria lurking in blood could be culprit in countless diseases
  14. haidut

    RoundUp (glyphosate) Linked To Alzheimers, Parkinson And ALS

    I posted about a similar study a few months ago, but this time the scientists are directly making the claim that RoundUp is causally involved with these conditions. The mechanism of action is again glycine antagonism / deletion by glyphosate. Monsanto's Roundup Weedkiller Linked to Alzheimer's...
  15. haidut

    Shockingly Successful Trial Shows Copper Dissolved In Dmso Treats Als

    I posted some studies before showing that ALS is a disease of mitochondrial origin and delivering copper directly to the motor neurons may be a viable treatment. Here are some of the previous posts on that: Copper May Treat Als | Ray Peat Forum More evidence that diseases like ALS are...
  16. haidut

    The Health Dangers Of Emf

    I was surprised to see this posted on Reddit, but there it was. This subreddit is titled "Electromagnetic fields cause cancer, EHS, MS, ALS, MCS, parkinson's, alzheimer's, candida, mold". https://www.reddit.com/r/Electromagnetics/ It has some very interesting posts and the one that caught my...
  17. haidut

    Stress May Be The Primary Cause Of Als

    The study claims that the neurological symptoms of ALS may be caused by retroviruses living inside every human being. Typically, the retroviruses are dormant and do not cause any harm to the individual. However, stress, toxins, and estrogen powerfully activate the retroviruses and as such may be...
  18. haidut

    An Antiglutamatergic Drug Prevents Foggy Brain Of Old Age

    I don't see a reason why it would not be helpful for all cases of foggy brain, not just in the elderly, considering Ray has written that the excitotoxicity by glutamate is behind many brain conditions including depression. A natural alternative would be the amino acid theanine and/or magnesium...
  19. haidut

    Cholesterol May Protect The Brain From Diseases Like Als

    The study shows the importance of cholesterol and two of its metabolite for the survival of motor neurons. Motor neurons get damages in diseases like ALS. I think the study underscores the importance of cholesterol for health and hints that structurally similar metabolites like pregnenolone and...
  20. haidut

    More Evidence That Diseases Like ALS Are Mitochondrial

    I have posted before on this topic, including studies that show copper supplementation extends the life of ALS rodent models by boosting activity of cytochrome C. This is the latest development. When Mitochondria Don't Get Moving, Motor Neuron Disease May Develop "...Researchers led by Janet...
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