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als

  1. haidut

    Muscular dystrophy may be driven by estrogen

    Aside from implicating estrogen in yet another "mysterious" chronic, incurable condition the study below is also worth considering due to the fact that the cases it looked at were all "hereditary" muscular dystrophy. Why put hereditary in quotes? Well, because as the study makes it quite clear...
    • haidut
    • Thread
    • als dystrophy e2 estradiol estrogen genetic hereditary muscle
    • Replies: 0
    • Forum: Scientific Studies
  2. haidut

    Blocking PUFA metabolism may treat Amyotrophic Lateral Sclerosis (ALS)

    The disease ALS needs no introduction. It is perhaps the most dreaded disease in current/former athletes as it is currently considered incurable, invariably lethal, and is known to strike athletes in much higher rates than the general population. Medicine claims that about 10% of the ALS cases...
    • haidut
    • Thread
    • als inflammation leukotriene lipoxygenase lox oxidative stress pufa ros
    • Replies: 8
    • Forum: Scientific Studies
  3. A

    Consideration of Gravity as a Possible Etiological Factor in Amyotrophic Lateral Sclerosis

    https://pubmed.ncbi.nlm.nih.gov/31442918 Abstract Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with an unknown mechanism of onset that predominantly impairs the upper and lower motor neurons. Components of the sensory and autonomic nervous system were once thought to be...
  4. A

    FDA advisers narrowly side against an experimental ALS drug

    https://www.nytimes.com/2022/03/30/health/als-treatment-amx0035.html By a narrow margin, a federal panel of independent medical experts concluded Wednesday that there is not yet enough evidence that an experimental therapy for amyotrophic lateral sclerosis, commonly known as A.L.S., is effective...
  5. A

    Niclosamide may be a therapeutic candidate for ALS

    Amyotrophic lateral sclerosis (ALS) is characterized by progressive motor neuron loss in the brain and spinal cord; however, its etiology is unknown, and no curative treatment exists. TAR DNA-binding protein 43 (TDP-43), encoded by TARDBP, is a genetic mutation observed in 2-5% of familial ALS...
  6. Aimer

    Ray Peat Interview Health Odyssey:Ray Peat and what the Cells in our body are really made of

    View: https://www.youtube.com/watch?v=u1lwpxV-srE&ab_channel=HealthOdyssey
    • Aimer
    • Thread
    • als cell high estrogen symptoms interviews menopause oxidative metabolism progest e progesterone dosage ray peat
    • Replies: 1
    • Forum: Interviews
  7. Lejeboca

    Ray Peat Interview October 18 2021 - One Radio Network

    Copying @RealNeat 's posting into a separate thread. ORN Bitchute channel has the interview posted as well View: https://www.bitchute.com/video/oBECLPlsv5PE/
    • Lejeboca
    • Thread
    • als high estrogen symptoms interview menopose oxidative metabolism progest e progesterone dosage ray peat
    • Replies: 1
    • Forum: Interviews
  8. Mauritio

    Serotonin, PUFA and histamine increase leaky brain

    This is just just another angle showing how stress hormones and PUFA affect the whole body negatively. Increased Blood-brain-barrier permeability(leaky brain) is linked to many diseases : "Blood–brain barrier dysfunction contributes to pathology in a range of neurological conditions including...
  9. haidut

    DHT, not T, likely the "active" androgen in heart and brain

    Interesting study, done on baboons (so should have good relevance for humans), demonstrating that the cardiovascular system (CVS) exclusively accumulates and recognizes (at the receptor level) DHT, instead of testosterone (T). In fact, the androgen receptor in CVS is so structurally different it...
    • haidut
    • Thread
    • active als androgen brain cardiovascular dht heart nervous
    • Replies: 22
    • Forum: Scientific Studies
  10. haidut

    Niacinamide may treat ALS by improving energetic state

    Another study sent to me by the Austrian collaborator. Once again, the energetic origin of "incurable" diseases like amyotrophic lateral sclerosis (ALS) is on full display. The study elucidates that ALL types of ALS are characterized by metabolic/energetic abnormalities and the metabolic...
    • haidut
    • Thread
    • als atp glycolysis lactate niacinamide nicotinamide oxphos vitamin b3 warburg
    • Replies: 0
    • Forum: Scientific Studies
  11. B

    Can Riboflavin Increase Cholesterol? Experiences With Riboflavin Please?

    I have always had very low cholesterol, and the necessity of taking thyroid meds has lowered it further. Various ways have been reported to increase cholesterol. The typically suggested methods to increase cholesterol include consuming extra cholesterol and consuming extra sugar. I found only...
    • Bingo
    • Thread
    • als cholesterol eds famotadine ibs pregnenolone riboflavin rosacea steroid hormones
    • Replies: 4
    • Forum: Cholesterol
  12. haidut

    Some ALS Cases May Be Cured By Vitamin B2 (riboflavin)

    A rather fascinating case study/report, which, despite its misleading and convoluted description, suggests yet again that motor neuron diseases such as Amyotropic Lateral Sclerosis (ALS) are nothing but severe mitochondrial/energetic dysfunction that can often be remediated quite easily. This is...
    • haidut
    • Thread
    • als cure dysfunction energetic mitochondria riboflavin treat vitamin b2
    • Replies: 2
    • Forum: Scientific Studies
  13. haidut

    Niacinamide May Improve Symptoms Of ALS

    Just over a week ago I posted a thread on ALS being linked to increased fatty acid oxidation (FAO) and as such a decreased glucose availability/oxidation. ALS Tied To Increased Fat Oxidation (FAO), Increasing Glucose May Treat It Now, the study below further corroborates this FAO-disease...
    • haidut
    • Thread
    • als endotoxin fao lps microbiome niacinamide vitamin b3
    • Replies: 1
    • Forum: Scientific Studies
  14. haidut

    ALS Tied To Increased Fat Oxidation (FAO), Increasing Glucose May Treat It

    I made a few posts in the past about ALS characterized by adrenal hyperactivity and suppressed gonadal function, as well as mitochondrial dysfunction and copper deficiency. Also, non-familial ALS is known to occurs 4-5 times more often in active/retired elite athletes. All of these findings...
    • haidut
    • Thread
    • als diet fao fatty acid oxidation glucose glycolysis metabolic metabolism
    • Replies: 17
    • Forum: Scientific Studies
  15. haidut

    Niacinamide May Treat ALS (and Stroke)

    I posted a few studies in the past demonstrating that ALS is a mitochondrial/metabolic disease and as such can be treated with pro-metabolic therapies like thyroid or copper (currently in clinical trials). This new study shows that raising NAD levels with the NAD precursor nicotinamide...
  16. haidut

    White-collar Jobs Linked To ALS And Parkinson

    Ever since ALS and Parkinson were formally introduced into the medical vocabulary, the medical industry has been trying to explain their increasing incidence with a variety of bizarre genetic stories. The genetic explanation started to collapse in the late 90s when it became evident that 90% of...
    • haidut
    • Thread
    • administrative als jobs occupation office parkinson's stress white-collar
    • Replies: 15
    • Forum: Scientific Studies
  17. haidut

    Exposure To EMF May Cause ALS

    I am posting this not so much because the link is strong but because the official message is that EMF is "completely benign" and cannot cause any disease because there is no known mechanism of action for it. That is of course a lie, and I posted a Q&A on Reddit that occurred a few years ago in...
    • haidut
    • Thread
    • als causative electric shock electrical fields electromagnetic radiation emf metabolism mitochondria neurodegenerative
    • Replies: 19
    • Forum: Scientific Studies
  18. haidut

    Caffeine Protects Against Dementia (AD), ALS, Parkinson, And Huntington Disease

    The link between caffeine intake and lower risk of neurodegenerative conditions has been established before but the mechanism of action was unknown. This study discovered one possible mechanism and also confirmed the associative findings in vivo using a mouse model. The HED was 150mg - 300mg...
    • haidut
    • Thread
    • als alzheimer's caffeine dementia huntington's nmnat2 parkinson's protective treatment
    • Replies: 12
    • Forum: Scientific Studies
  19. haidut

    5α-Dihydroprogesterone (5α-DHP) - Potent Role In Neurodegenerative Conditions

    While researching saturated steroids and their effects on the brain, I noticed a number of highly promosing studies demonstrating benefit of such steroid for a variety of neurodegenerative conditions such as MS, ALS, Alzheimer, Parkinson, etc. Ray has written extensively on the topic of...
    • haidut
    • Thread
    • 5α-dhp 5α-dihydroprogesterone als alzheimer's antiaging brain diabetes multiple sclerosis neurodegenerative neuropathy neurosteroid tbi
    • Replies: 13
    • Forum: Scientific Studies
  20. M

    Endotoxin And Iron Finally Recognized As Potential Causes Of Many Diseases

    [ moderator edit: threads merged ] Bacteria lurking in blood could be culprit in countless diseases
    • Miso
    • Thread
    • als alzheimer's arthritis bse cancer clotting cvd endotoxin fibrin heart attack inflammation iron lps stroke thrombosis
    • Replies: 55
    • Forum: Scientific Studies
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