Mauritio
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- Joined
- Feb 26, 2018
- Messages
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I have already posted a study about vitamin E succinate (VES) beeing able to decrease liver carcinoma by 77%
(Vitamin E Succinate Very Effective Against Liver Carcinoma ,acetate Form Increases It)
There have previously been studies on VES and melanoma in vitro and they all showed decreases in tumor, while other kinds of vitamin E where not effective.
"However, other forms of vitamin E such as DL-alpha-tocopherol free alcohol, Aquasol DL-alpha-tocopherol acetate, DL-alpha-tocopherol nicotinate, or sodium succinate with an equivalent volume of ethanol, at similar concentrations, were ineffective."
(Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture - PubMed)
(Inhibition of angiogenesis and promotion of melanoma dormancy by vitamin E succinate - PubMed)
Now this study looked at the in vivo effect of VES on melanoma in mice .
They found that :
"Tumors in the control groups grew rapidly, reaching an average volume of
2350 ± 798 µL by day 15 after the inoculation of
B16F10 melanoma cells. In contrast, the inhibition of tumor growth on mice that were administered VES intraperitoneally was profound, with tumor volume remaining at an average of 367 ± 136 µL (Fig 2, A and B)."
That's a tumor size difference of 650% !
I have attached a picture of the tumor in vivo. It's a bit TMI so ,be warned.
The mouse on the left has the untreated melanoma , on the right melanoma treated with VES . It looks like the difference of an orange to a pea.
They also looked at the apoptosis rate in the tumor cells , which increased by 58 % :
"Melanoma tumors from VES-treated mice demonstrated a statistically significant increase in apoptosis compared with those from the control (76% ± 9% vs 18% ± 1%, P = .0256, Fig 3, B, Fig 4)."
(Vitamin E Succinate Very Effective Against Liver Carcinoma ,acetate Form Increases It)
There have previously been studies on VES and melanoma in vitro and they all showed decreases in tumor, while other kinds of vitamin E where not effective.
"However, other forms of vitamin E such as DL-alpha-tocopherol free alcohol, Aquasol DL-alpha-tocopherol acetate, DL-alpha-tocopherol nicotinate, or sodium succinate with an equivalent volume of ethanol, at similar concentrations, were ineffective."
(Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture - PubMed)
(Inhibition of angiogenesis and promotion of melanoma dormancy by vitamin E succinate - PubMed)
Now this study looked at the in vivo effect of VES on melanoma in mice .
They found that :
"Tumors in the control groups grew rapidly, reaching an average volume of
2350 ± 798 µL by day 15 after the inoculation of
B16F10 melanoma cells. In contrast, the inhibition of tumor growth on mice that were administered VES intraperitoneally was profound, with tumor volume remaining at an average of 367 ± 136 µL (Fig 2, A and B)."
That's a tumor size difference of 650% !
I have attached a picture of the tumor in vivo. It's a bit TMI so ,be warned.
The mouse on the left has the untreated melanoma , on the right melanoma treated with VES . It looks like the difference of an orange to a pea.
They also looked at the apoptosis rate in the tumor cells , which increased by 58 % :
"Melanoma tumors from VES-treated mice demonstrated a statistically significant increase in apoptosis compared with those from the control (76% ± 9% vs 18% ± 1%, P = .0256, Fig 3, B, Fig 4)."
Vitamin E inhibits melanoma growth in mice - PubMed
This is the first report of the antimelanoma effect of VES in vivo. The mechanism of the antimelanoma effect of VES in vivo involves the promotion of tumor cell apoptosis. These findings support future investigations of VES as a therapeutic micronutrient against melanoma.
pubmed.ncbi.nlm.nih.gov
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