Hi everyone,
I read on Ray Peat’s site at http://raypeat.com/articles/articles/th ... ones.shtml that Young people produce about 12 to 15 milligrams of DHEA per day, and that amount decreases by about 2 mg. per day for every decade after the age of 30. I also read that about 4MG of DHEA per day will usually replenish a 50 year olds DHEA levels to those found in youth. I am not doubting the information, but can anyone please provide the studies or scientific data that Ray likely used to come to these conclusions ? Any links or references would be appreciated.
What would be the likely replacement dose of pregnenolone to restore a 50 year olds levels to those found in youth ? If pregenolone production falls off at about the same rate as DHEA and if it is absorbed in about the same way, I would guess it would be around 10 MG. I come to this conclusion since Ray says that at 30, both men and women produce about 30 to 50 MG of pregnenolone daily. So, 12 MG of DHEA divided by 3 gives the 4 MG replacement dose of DHEA and 30 / 3 would give the 10 MG replacement dose of pregnenolone. I could well be wrong here, it's just a guess based on what I read at the site. Any studies, references, or scientific data regarding pregnenolone and replacement dosages would also be appreciated.
I am a 47 year old man and I would like to bring my pregnenolone and DHEA levels up to where they likely were at about 25- 30. I do not have a lot of money for blood tests (and there is no way to know now what my personal levels were at 25 to 30) but I would like to supplement with about 5 mg of pregnenolone and 5 mg of DHEA per day for awhile to see how it makes me feel. How long does it usually take to notice anything ?
I purchased some 10 mg pregnenolone tablets from Source Naturals, which I cut in half with a pill cutter. I usually get my supplements from iherb.com and I could get 5 mg micronized sublingual tablets from Douglas Laboratories, 5 mg tablets from Enzymatic Therapy, or I could get 10 mg tablets from Nutricology, Natrol, or Allergy research group,and split them. Does anyone have a recommendation for a brand of DHEA and/or pregnenolone that I can conveniently use in low 5 mg dosages ? Is delivery method important , e.g., sublingual, micronized, just swallowing the pill, etc..
Are there advantages or disadvantages to taking pregnenolone and DHEA together ? Is it likely desirable to take some type of aromotase inhibitor or estrogen modulator like DIM or Chrysin ? I think the problem with Chrysin is finding something that is bioavailable. At http://examine.com/stacks/anti-estrogen.html it says that Grape seed extract and Eurycoma Longifolia Jack can have anti-estrogen effects, but these seem to be somewhat expensive supplements, especially the Longjack. I also looked at super-miraforte made by LEF, but it is expensive as well.
As far as I know I am healthy. I have exercised for most of my life and as far as amount weight lifted, number of reps, etc., I still do as much as I always did. Strength wise I seem fine and still have a slim and athletic build. I think the main things I notice getting older is that I do not seem to have quite the energy I did in my twenties and early thirties, and I do not seem to sleep as soundly, i.e., I sleep a few hours then wake up. My sleep does not seem to be as restorative as it was when I was younger. Low dose (300 mcg of 6 hour time release melatonin seems to help, but does not make things like they were when younger). Sexually, everything functions and I am still motivated and still enjoy it, but drive and orgasms are not nearly as intense as they were in my twenties or early thirties. Orgasm used to be more of a "whole body" experience, I used to have and almost "high" or slightly dizzy / relaxed feeling afterwards. Now, the pleasure is more genitally focused, and not as satisfying overall. This may be a normal part of aging, but I would like to improve things if I can.
I think stress and boredom are part of the problem but also I think it's just getting older. I have tried various herbs like Ginseng, Rhodiola, and "Adrenal Health" by Gaia Herbs. I think these things helped a little but the affect was not as powerful as desired.
I would appreciate any help or suggestions anyone can offer. I would like to hear from anyone with similar experiences, along with what you tried that worked or did not work.
Thanks for your help.
Sincerely,
John
I read on Ray Peat’s site at http://raypeat.com/articles/articles/th ... ones.shtml that Young people produce about 12 to 15 milligrams of DHEA per day, and that amount decreases by about 2 mg. per day for every decade after the age of 30. I also read that about 4MG of DHEA per day will usually replenish a 50 year olds DHEA levels to those found in youth. I am not doubting the information, but can anyone please provide the studies or scientific data that Ray likely used to come to these conclusions ? Any links or references would be appreciated.
What would be the likely replacement dose of pregnenolone to restore a 50 year olds levels to those found in youth ? If pregenolone production falls off at about the same rate as DHEA and if it is absorbed in about the same way, I would guess it would be around 10 MG. I come to this conclusion since Ray says that at 30, both men and women produce about 30 to 50 MG of pregnenolone daily. So, 12 MG of DHEA divided by 3 gives the 4 MG replacement dose of DHEA and 30 / 3 would give the 10 MG replacement dose of pregnenolone. I could well be wrong here, it's just a guess based on what I read at the site. Any studies, references, or scientific data regarding pregnenolone and replacement dosages would also be appreciated.
I am a 47 year old man and I would like to bring my pregnenolone and DHEA levels up to where they likely were at about 25- 30. I do not have a lot of money for blood tests (and there is no way to know now what my personal levels were at 25 to 30) but I would like to supplement with about 5 mg of pregnenolone and 5 mg of DHEA per day for awhile to see how it makes me feel. How long does it usually take to notice anything ?
I purchased some 10 mg pregnenolone tablets from Source Naturals, which I cut in half with a pill cutter. I usually get my supplements from iherb.com and I could get 5 mg micronized sublingual tablets from Douglas Laboratories, 5 mg tablets from Enzymatic Therapy, or I could get 10 mg tablets from Nutricology, Natrol, or Allergy research group,and split them. Does anyone have a recommendation for a brand of DHEA and/or pregnenolone that I can conveniently use in low 5 mg dosages ? Is delivery method important , e.g., sublingual, micronized, just swallowing the pill, etc..
Are there advantages or disadvantages to taking pregnenolone and DHEA together ? Is it likely desirable to take some type of aromotase inhibitor or estrogen modulator like DIM or Chrysin ? I think the problem with Chrysin is finding something that is bioavailable. At http://examine.com/stacks/anti-estrogen.html it says that Grape seed extract and Eurycoma Longifolia Jack can have anti-estrogen effects, but these seem to be somewhat expensive supplements, especially the Longjack. I also looked at super-miraforte made by LEF, but it is expensive as well.
As far as I know I am healthy. I have exercised for most of my life and as far as amount weight lifted, number of reps, etc., I still do as much as I always did. Strength wise I seem fine and still have a slim and athletic build. I think the main things I notice getting older is that I do not seem to have quite the energy I did in my twenties and early thirties, and I do not seem to sleep as soundly, i.e., I sleep a few hours then wake up. My sleep does not seem to be as restorative as it was when I was younger. Low dose (300 mcg of 6 hour time release melatonin seems to help, but does not make things like they were when younger). Sexually, everything functions and I am still motivated and still enjoy it, but drive and orgasms are not nearly as intense as they were in my twenties or early thirties. Orgasm used to be more of a "whole body" experience, I used to have and almost "high" or slightly dizzy / relaxed feeling afterwards. Now, the pleasure is more genitally focused, and not as satisfying overall. This may be a normal part of aging, but I would like to improve things if I can.
I think stress and boredom are part of the problem but also I think it's just getting older. I have tried various herbs like Ginseng, Rhodiola, and "Adrenal Health" by Gaia Herbs. I think these things helped a little but the affect was not as powerful as desired.
I would appreciate any help or suggestions anyone can offer. I would like to hear from anyone with similar experiences, along with what you tried that worked or did not work.
Thanks for your help.
Sincerely,
John