First time posting
Tried using a 10mg Preg lozenge and found (very quickly) it created anger for me. Suddenly I'm an ***hole! (& I mean, I have my moments, but usually in no way like what this made me feel & do & say . There was a brief period of mental clarity & physical energy before the anger kicked in I have to say) Stopped using it just as quickly and now am back to feeling a bit sad & embarrassed) It pretty much happened the twice I took it over a couple of days in consecutive weeks, so fairly certain that's what did it. Does this seem to be a common side effect? (female, post-meno, normally just using Progesterone cream, a 75mcg Synthroid generic, recently starting to use fruits, milk, niacinamide, gelatin etc) & reading up on how to benefit from Peat nutritional ideas. Would Preg be turning into testosterone? & so quickly? Any ideas on why & if it is, should I supp with Preg at all given that reaction? My main goals are upping metabolism (raising lower temp/heart rate), & attaining some control over the juggernaut of creeping belly fat. Have otherwise not gained excessive body fat any other place but there in the past 5 or so years.
It's not testosterone, it is allopregnanolone into which pregnenolone quickly converts through the progesterone pathways. For a long time clinicians were puzzled how come low doses of progesterone (which tends to metabolize quickly into downstream steroids like allopregnanolone) worsens mood and social intercation while high dose makes people nice and mellow. It wasn't until allopregnanolone was discovered that this riddle got solved.
Allopregnanolone - Wikipedia, the free encyclopedia
"...Increased levels of allopregnanolone can produce paradoxical effects, including negative mood, anxiety, irritability, and aggression.[28][29][30] This appears to be because allopregnanolone possesses biphasic, U-shaped actions at the GABAA receptor – moderate level increases (in the range of 1.5–2 nM/L total allopregnanolone, which are approximately equivalent to luteal phase levels) inhibit the activity of the receptor, while lower and higher concentration increases stimulate it.[28][29] This seems to be a common effect of many GABAA receptor positive allosteric modulators.[25][30] In accordance, acute administration of low doses of micronized progesterone (which reliably elevates allopregnanolone levels), have been found to have negative effects on mood, while higher doses have a neutral effect."