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Thanks. So, basically drinking more milk?
Colostrum is packed with lactoferrin AFAIK, but also contains other growth peptides and trace amount of even hormones (it contains IGF-1 in small amounts and it is forbidden to use in professional sports due to doping laws), considering it is basically the first batch of breastmilk after birth you can see how interesting it would be for science just by fully looking into its contents and the ratio between the amounts.
In other words, colostrum is critical for optimal health after birth and there for crucial to life itself.
Bovine lactoferrin and Crohn's disease: a case study.
Bovine lactoferrin and Crohn's disease: a case study. - PubMed - NCBI
Concentration of lactoferrin and transferrin throughout lactation in cow's colostrum and milk.
Concentration of lactoferrin and transferrin throughout lactation in cow's colostrum and milk. - PubMed - NCBI
"The evolution of the concentration of lactoferrin and transferrin was studied in cow's colostrum and milk throughout lactation. The highest concentrations of both proteins were found in the first milking (0.83 mg/ml for lactoferrin and 1.07 mg/ml for transferrin), decreasing sharply during the first days of lactation (colostral period). Thereafter, the concentrations of these proteins decreased slowly, reaching their definitive values during the third week post-partum (0.09 mg/ml for lactoferrin and 0.02 mg/ml for transferrin). The ratio transferrin/albumin in colostrum (first milking), mature milk, milk from mastitic cows and serum was determined, and found to be four times greater in colostrum than in mature or mastitic milk, suggesting a specific transport of transferrin from blood to milk."
Whey Protein Components - Lactalbumin and Lactoferrin - Improve Energy Balance and Metabolism
Whey Protein Components - Lactalbumin and Lactoferrin - Improve Energy Balance and Metabolism
"Notably, lactoferrin produced sustained weight and fat loss, and attenuated the reduction in energy expenditure associated with calorie restriction. Lactalbumin and lactoferrin decreased plasma leptin and insulin, and lactalbumin increased peptide YY. Whey, lactalbumin and lactoferrin improved glucose clearance partly through differential upregulation of glucoregulatory transcripts in the liver and skeletal muscle. Interestingly, lactalbumin and lactoferrin decreased hepatic lipidosis partly through downregulation of lipogenic and/or upregulation of β-oxidation transcripts, and differentially modulated cecal bacterial populations."
Effects of colostrum serum on the serotonergic system in the dorsal raphe nuclei of exercised rats.
Effects of colostrum serum on the serotonergic system in the dorsal raphe nuclei of exercised rats. - PubMed - NCBI
"The time to exhaustion in response to treadmill running increased after treatment with colostrum serum. These results show that exhaustive exercise led to over activation of the serotonergic system in the dorsal raphe nuclei, and that treatment with colostrum serum suppressed of the exercise-induced expression of tryptophan hydroxylase (TPH) and serotonin (5-HT). The results also indicated that exhaustive exercise induced 5-HT1A autoreceptor and serotonin transporter (5-HTT) overexpression in the dorsal raphe nuclei, and that colostrum serum treatment suppressed exhaustive exercise-induced 5-HT1A and 5-HTT expression in the dorsal raphe nuclei. The most effective dose of colostrum serum was 100 mg/kg"
"Overall, our study suggests that colostrum serum has positive effects on exercise performance and recovery by increasing the resistance to fatigue."
Now what I dont get from this last study is that it says it increases resistance to fatigue (strongly suggest a lowering of serotonin in the brain), however they also measure the 5ht1a receptor, 5htt (serotonin transporter?) and TPH level in the DRN (note that when the 5ht1a autoreceptor in the DRN is normally activated this lowers whole brain serotonin, due it to be being an inhibitory receptor).
Oddly enough the net effect of all of this clearly seems increasing time to exhaustion suggesting an effect of lowering serotonin in the brain (just like how BCAA lowers serotonin in the brain and through that mechanism has an anti fatigue effect).
Merry X-Mas to all
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