Progesterone inhibits gastrointestinal tract motility

[Adora77]

Has anyone noticed a slower transit time or constipation while taking progesterone supplements?

Progesterone Inhibitory Role on Gastrointestinal Motility

Progesterone is a steroidal hormone that is produced from the corpus luteum of the ovaries and from the placenta. The main function of progesterone is to promote the secretory differentiation in the endometrium of the uterus and to maintain pregnancy ...

www.ncbi.nlm.nih.gov

"Progesterone inhibits gastrointestinal tract motility by acting directly on gut smooth muscle cell surface PRs. This leads to rapid changes in the intracellular second messengers that affect contraction relaxation pathways without the involvement of gene transcription."

 

[Elie]

Some experience gi discomfort.
Do you have starchy or fruit snacks in between meals?

 

[Blaze]

Has anyone noticed a slower transit time or constipation while taking progesterone supplements?

Not me, but very interesting study, thanks for posting it.

 

[shakemondown]

where do you source progesty?

 

[miquelangeles]

Has anyone noticed a slower transit time or constipation while taking progesterone supplements?

Yes.

 

[Limon9]

Yeah. Progesterone constipated me so badly my head exploded, and I recovered with high-dose estrogens therapy (neuroprotectant!)

 

[Mad]

where do you source progesty?

Dr. Peat's Progest E Oil Complex, 34 ml

Kenogen Progest E by Ray Peat is a natural bioidentical progesterone oil derived from wild yam. The best there is! Buy yours today with Free Shipping!

www.longnaturalhealth.com

 

[sweetpeat]

Has anyone noticed a slower transit time or constipation while taking progesterone supplements?

Most definitely.

 

[L_C]

Personally, I haven't had issues with progestereone causing digestive problems. It does withdraw estrogen out of the tissues. Perhaps, it's excess estrogen what's causing the problems.

 

[Elie]

Yeah. Progesterone constipated me so badly my head exploded, and I recovered with high-dose estrogens therapy (neuroprotectant!)

I'd love to understand the biochemistry and physiology of this response.
But to do so, i think we'd also need some context of your personal health history / situation.