ecstatichamster
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- Joined
- Nov 21, 2015
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I'd love to learn more about studies you may have found. Thank you.
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[QUOTE = "ecstatichamster, post: 463249, member: 3389"] La glicolisi come punto finale, è il modo in cui il Dr. Peat usa il termine, risultando in piruvato che viene metabolizzato in acido lattico per generare ATP piuttosto che procedere attraverso il ciclo di Krebs. [/CITAZIONE]
@ecstatichamster Can you clarify this point? why does pyruvate not enter Krebs correctly and produce lactate?
In order for pyruvate to enter TCA cycle/oxidative phosphorylation it needs to get converted to acetyl CoA through the pyruvate dehydrogenase complex.
There can be many reasons as to why pyruvate --> acetyl CoA conversion wouldn't work properly. Could be a lack any of the cofactors, mainly thiamine pyrophosphate (vitamin b1) and magnesium, a low NAD+/NADH ratio will also push pyruvate towards lactate instead of acetyl CoA.
thank you.
In order for pyruvate to enter TCA cycle/oxidative phosphorylation it needs to get converted to acetyl CoA through the pyruvate dehydrogenase complex.
There can be many reasons as to why pyruvate --> acetyl CoA conversion wouldn't work properly. Could be a lack any of the cofactors, mainly thiamine pyrophosphate (vitamin b1) and magnesium, a low NAD+/NADH ratio will also push pyruvate towards lactate instead of acetyl CoA.
Also, PDH is under regulation by pyruvate dehydrogenase kinase (PDK) which inactivates one of the enzymes in PDH.
Haidut has talked about suppressing PDK as being therapeutic in different contexts for restoring energy metabolism, vitamin B1 seems to have this effect The Anti-cancer Chemical DCA May Treat Chronic Fatigue Syndrome (CFS)
Betaine is a positive regulator of mitochondrial respiration. - PubMed - NCBI
"Mitochondrial electron transport chain (ETC) complexes generate the mitochondrial membrane potential, which is essential to produce cellular energy, ATP. Reduced mitochondrial respiration and energy status have been found in many human pathological conditions including aging, cancer, and neurodegenerative disease. In this study we investigated whether betaine directly targets mitochondria. We show that betaine treatment leads to an upregulation of mitochondrial respiration and cytochrome c oxidase activity in H2.35 cells, the proposed rate limiting enzyme of ETC in vivo. Following treatment, the mitochondrial membrane potential was increased and cellular energy levels were elevated."
Should I then buy thiamine pyrophosphate or continue with the HCL form?
Honestly I am not the best person to answer what form is best/most bioavailable.
Dr Lonsdale at hormonesmatter.com is probably the most knowledgeable (and experienced) person on earth when it comes to thiamine and its clinical significance, I believe he recommends TFFD + magnesium.