1. haidut

    Saturated Fat (palmitate) Does NOT Activate TLR4

    We must have had hundreds of discussions on this topic on the forum. Some forum users strongly believe that saturated fat (SFA) increases inflammation by binding to and activating the endotoxin (LPS) receptor TLR4. Among all SFA, palmitate is the one most commonly blamed and has been...
  2. P

    Betaine Lowers FFA And Improve Insulin Sensitivity And Adiponectine Level In High Fat Fed Animal

    Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease Endoplasmic reticulum (ER) stress plays a critical role in adipose tissue dysfunction and insulin resistance in a variety of experimental...
  3. Elchapchapchapo

    Haidut On Insulin Sensitivity / Insulin Resistance

    Insulin resistance is caused by elevated fatty acids (FFA)
  4. P

    Brain Insulin Resistance Identified As Possible New Link Between Alzheimer's Disease, Diabetes

    It says brains inability to burn glucose is responsible for Alzheimer's disease.caused by insulin's resistance in brain, and that probably mediated by inflammation. Brain Insulin Resistance Contributes to Cognitive Decline in Alzheimer's Disease – PR News...
  5. P

    A Central Role For JNK(inflammation) In Obesity And Insulin Resistance

    A central role for JNK in obesity and insulin resistance. - PubMed - NCBI Obesity is closely associated with insulin resistance and establishes the leading risk factor for type 2 diabetes mellitus, yet the molecular mechanisms of this association are poorly understood. The c-Jun amino-terminal...
  6. P

    Inflammation Mediates Free Fatty Acid-induced Insulin Resistance

    JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. - PubMed - NCBI Lipid infusion and high fat feeding are established causes of systemic and adipose tissue insulin resistance. In this study, we treated 3T3-L1 adipocytes with a mixture...
  7. P

    Saturated Fatty Acids,including Lauric Acid Activates TLR4

    Some studies showing coconut oil has anti stress effects,but this one surprised me! Fatty Acids Modulate Toll-like Receptor 4 Activation through Regulation of Receptor Dimerization and Recruitment into Lipid Rafts in a Reactive Oxygen Species-dependent Manner The saturated fatty acids...
  8. R

    Hyperlipidemia Promotes Inflammation

    Saturated Fats Damage Health by Promoting Inflammation
  9. Dopamine

    Taurine Protects Against Heavy Metal Toxicity

    It looks like taurine protects against cadmium, iron, arsenic, lead, aluminum, mercury and other heavy metals. It has strong anti-oxidant properties I think largely mediated through increasing glutathione and increasing fecal/bile excretion of heavy metals. Taurine also protects against...
  10. Amazoniac

    A (chronic) Very Low Dose Endotoxin Exposure Might Be As Dangerous As An Acute One

    Treehuggers, @haidut forced me to post this study with the following comments: This, unlike the majority of studies on the effects of LPS, was done using a very low dose of endotoxin; according to them, something that is compatible with the circulating levels seen in chronic metabolic...
  11. P

    LRP5 Controls Bone Formation By Inhibiting Serotonin Synthesis In The Duodenum

    LRP5 - Wikipedia im so interest to find any info on how increase Lrp5(it strongly inhibit gut serotonin release) , only thing i found that upregulates the synthesis of it is vitamin D, and also Cholesterol. but who knows, maybe serotonin lowering effect of salt works through this pathway...
  12. P

    Some Pentoxifylline Studies

    Pentoxifylline Reverses Oxidative Mitochondrial Defect in Claudicating Skeletal Muscle The effect of pentoxifylline on filterability of normal red blood cells and their adhesiveness to cultured endothelial cells - Springer Pentoxifylline Neuroprotective Effects Are Possibly Related to Its...
  13. Koveras

    Clarification Needed On Vitamin A And Metabolism

    From: Sign In "We recently identified PKCδ as a key component of a mitochondrial feedback loop that regulates acetyl-coenzyme A (CoA) production from pyruvate. In this pathway, PKCδ acts simultaneously as the sensor of the reduction potential of cytochrome c, reflective of the electron...
  14. haidut

    Both Types Of Diabetes Are Caused By The Same Mechanism

    Ray has written on the similarities between type I and type II diabetes and how they are really the same disease, but of different severity. Modern medicine claimed for years that the two types are fundamentally different, and type I is an auto-immune condition. This article claims scientists in...
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