ibs

  1. haidut

    Fungi / Bacteria, Not Autoimmunity, Cause IBD (Chron's, UC) And IBS

    I posted a study recently that chronic alcohol consumption increases Candida overgrowth in the gut while simultaneously decreasing the number of benign bacteria. Candida Overgrowth Is A Major Factor In (alcoholic) Liver Damage / Cirrhosis Actually, the term "benign bacteria" is wrong as there...
    • haidut
    • Thread
    • cause chron's diet gut high-fat ibd ibs microbiome mycobiome ulcerative colitis
    • Replies: 53
    • Forum: Scientific Studies
  2. haidut

    Serotonin Antagonists As Treatment For IBD (Chron's UC, Etc)

    It is not common knowledge in research (but not clinical) circles that serotonin is the major cause of the so-called "irritable bowel syndrome" (IBS). As such, there are several large clinical trials using TPH inhibitors to lower serotonin synthesis and thus cure the condition. It is also known...
    • haidut
    • Thread
    • 5-ht7 antagonist chron's ibd ibs serotonin uc ulcerative colitis
    • Replies: 24
    • Forum: Scientific Studies
  3. P

    Ondansetron Works For Diarrhea-Predominant Irritable Bowel Syndrome

    Ondansetron Works for Diarrhea-Predominant Irritable Bowel Syndrome - NEJM Journal Watch This 5-HT3 receptor antagonist improved stool consistency and symptoms, with a low frequency of severe constipation. Ondansetron is a 5-hydroxytryptamine 3 receptor antagonist (5-HT3RA) used for the...
  4. haidut

    Cyproheptadine Effective For Functional GI Disorders

    Human study and with children, so safety was certainly a priority for this study. As you can see, a human dose of 0.14mg/kg cyproheptadine was effective in variety of "functional" disorders including the dreaded irritable bowel syndrome and functional dyspepsia. This study claims that for the...
  5. P

    LX-1031, A Tryptophan 5-hydroxylase Inhibitor That Reduces 5-HT Levels For The Potential Treatment O

    it is an under development drug but sounds interesting and i think it is not available on the market yet .it reduces serotonin formation in digestive system and it doesnt cross blood–brain barrier. http://www.ncbi.nlm.nih.gov/pubmed/21154152 LX-1031, being developed by Lexicon Pharmaceuticals...
  6. haidut

    Low-sugar substitutes linked to the epidemic of IBD / IBS

    The studies cited in this post match well with the "recent" news that dietary emulsifiers may be behind the dramatic increase of bowel diseases in the last 15 years. These studies not add things like maltodextrin and other low-sugar sweeteners to the mix of stuff to avoid. I think maltodextrin...
  7. haidut

    Clonidine May Be A Viable Therapy For IBD / IBS, And UC

    Irritable bowel syndrome / disease and ulcerative colitis have been known to be affected / triggered predominantly by stress, mediated by the sympathetic nervous system. As such, it appears logical that a drug like clonidine would be helpful and indeed the studies below claim that clonidne may...
  8. haidut

    Vitamin B6 May Help Conditions Such As IBS / IBD And Chron's

    Unlike other posts I made recently, the study used the common/inactive form of B6 (the Hcl salt) and the human equivalent dosage was 25mg-30mg for human. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4199223/
  9. haidut

    Caffeine can be used to manage IBS / IBD and Chron's

    I know people with IBS who swear by their morning coffee and cigarette. I am not encouraging smoking of course. http://www.ncbi.nlm.nih.gov/pubmed/23925589 "...Development of acute colitis is reduced upon caffeine treatment. The mechanism involves the down-regulation of CHI3L1 expression and...
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