1. Mitchell777

    Thoughts on using piperine to enhance oral bioavailability of emodin?

    After researching emodin, I have learnt that the oral bioavailability seems to be very low. This seems to be due to extensive metabolism into its glucuronide form. The study below which I will quote, suggests using piperine alongside emodin as a method to increase bioavailability, due to...
  2. Epik

    How high to go on Emodin

    Hi all, I was just wondering if there are any down sides in taking maybe 1g of Emodin a day to force cortisol down. Any side effects or possible issues coming off Emodin? If so, what should be my max dose a day? Thanks!
  3. md_a

    Ray Peat Interview Dr. Ray Peat, Ph.D – Your Health Questions Answered – February 21, 2022

  4. Mito

    Aloe-emodin is a highly potent mast cell stabilizer

    Aloe-emodin, a naturally occurring anthraquinone, is a highly potent mast cell stabilizer through activating mitochondrial calcium uniporter Abstract Mast cells play a fundamental role in immune system. Upon stimulation, they are activated via IgE dependent or independent pathway and then...
  5. E

    Cascara Sagrada/Emodin Beneficial For COVID-19

    However compounds like emodin that inhibit SARS entry, apparently by binding ACE2, might also have functions at several different human protein binding sites. The enzyme 11β-hydroxysteroid dehydrogenase type 1 is again argued to be a convenient model pharmacophore perhaps representing an...
  6. haidut

    Simple Intestinal Antiseptic As A Cure For Rheumatoid Arthritis (RA)

    The role of endotoxin in RA and other "autoimmune" conditions has been discussed by Ray many times in his articles and interviews. Apparently, the connection was firmly established as causative back in the early 20th century and complete cures were often readily obtained using a simple phenolic...
  7. haidut

    Cortisol And Aldosterone Cause Vascular Calcification

    In one of his newsletter circa 2015, Ray wrote about the role of aldosterone in heart failure, heart attacks, shock, and edema. He conjectured that aldosterone antagonists would one day be recognized as therapeutic for these conditions. Almost all types of heart disease start with vascular...
  8. haidut

    Low-dose Emodin Can Change Gut Microbiome And Alleviate Kidney DiseaseHere We Utilized A Rat CKD Mod

    As most people here know Ray is not in favor of "probiotics" supplements, with the possible exception of BioSporin. This study found that an enema with low-dose emodin changed the microbiome in a way that eliminated uremic toxins in a model of kidney disease and also alleviated the pathology of...
  9. haidut

    Achilles Heel Of Cancer Found - Its Addiction To Fat

    The public propaganda message has always been that cancer cells are addicted to glucose. As a result of that belief, one of the so-called "new wave" therapies in the treatment of cancer is to "starve" the cancer cells of glucose and hope that they die on their own. This usually has disastrous...
  10. haidut

    Lapodin - Liquid Emodin/β-lapachone Mix

    Peat has written many articles on the topic of quinones and their effects on metabolism / respiration. The earliest official work probably started around the time of William Koch in the early 20th century and continues to this day. Many people are familiar with the popular quinone CoQ10 but...
  11. haidut

    Amazing Medicinal Properties Of Emodin

    This thread is similar to the one I created for beta-lapachone and in support of the Lapodin supplement I released. Lapodin: https://raypeatforum.com/community/threads/lapodin-dietary-supplement-with-beta-lapachone-and-emodin.9423/ Beta-lapachone...