I wanted to ask you something. I recently bought 20grams of pregnenolone from healthnatura. I used up to about 500mg with no effect whatsoever. When I used your product topically, even 6 drops would be enough to give a noticeable and powerful effect. The only thing that I'm doing different now is using testosterone. Do you think the route of administration is important here? Obviously healthnatura has real pregnenolone; I am just completely shocked that I notice nothing from such a high dose orally.Yes, if pregnenolone is dissolved in vitamin E it can be applied to the gums just like any other steroids. Pregnenolone is very hard to dissolve in anything except chloroform, and this is why we don't have bigger amounts per ml in our products.
http://www.jpharmsci.org/article/S0095-9553(15)32106-5/pdf
We are testing some solubility enhancing trick but those likely won't increase the solubility of pregnenolone more than say 50% (in ethanol or oil) so it may help avoid precipitation in our supplements but won't allow one to pack up as much pregnenolone in vitamin E as say progesterone in Progest-E. Progesterone is much more soluble than pregnenolone, regardless of the solvent.