yes i think niacinamide helps considerably in preventing the serotonergic symptoms of methylene blue. a good combo. But do think higher doses of niacinamide, 500mg -1g, could be counterproductive alongside MB?
Studies done by the company pushing nicotinamide riboside (NR) showed that a dose of 300mg and a dose of 1,000mg lead to the same increase in NAD after 24 hours. So, I guess there is probably no need to go up to 1g unless you have very serious inflammation. The 300mg daily dose also happens to be what Ray has consistently been recommending.