ecstatichamster
Member
- Joined
- Nov 21, 2015
- Messages
- 10,552
I am enthusiastically supportive of attacking lifestyle choices, including IF.
I haven’t heard Ray Peat discuss differences between different intervals of fasting. Presumably the concerns he raises about 24 hr + fasting, where glycogen store are probably depleted, do not apply to 16hr fasts.
I’m pretty sure having a high proportion of lean mass to body fat correlates with longevity, but I don’t feel like looking it up. There’s no way a BMI of 25-30 is optimal, especially for men. Where does Ray Peat say that? He certainly isn’t that fat.
Here’s a 2012 rodent study that compared an ad libitum high fat diet and a time restricted eating high fat diet, where the time restricted group did way better than the ad lib group. Both groups ate the same amount of calories yet only the fasting mice avoided obesity and disease.
Time restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high fat diet
Summary:
While diet-induced obesity has been exclusively attributed to increased caloric intake from fat, animals fed high fat diet (HFD) ad libitum (ad lib) eat frequently throughout day and night disrupting the normal feeding cycle. To test whether obesity and metabolic diseases result from HFD or disruption of metabolic cycles, we subjected mice to either ad lib or time restricted feeding (tRF) of a HFD for 8 h/day. Mice under tRF consume equivalent calories from HFD as those with ad libaccess, yet are protected against obesity, hyperinsulinemia, hepatic steatosis, inflammation, and have improved motor coordination. The tRF regimen improved CREB, mTOR and AMPK pathway function and oscillations of the circadian clock and their target genes' expression. These changes in catabolic and anabolic pathways altered liver metabolome, improved nutrient utilization and energy expenditure. We demonstrate in mice that tRF regimen is a non-pharmacological strategy against obesity and associated diseases.
"Biggest Loser" Fitness Guru (age 51) Suffers Serious Heart Attack