I took 3 tablets in total, which I think is 75 mg. By opposite effect, what in particular do you mean? Better mood and more physical and mental energy? Funny that 12.5 mg would have the best effect on someone if each tablet is 25 mg.CellularIconoclast said:Ben said:I tried Benadryl last night to see how it effect me, expecting positive effects. I found that it gives me the same helpless, depressed, feeling as caffeine. It lasts until the next day.
Ben, what dose of Benadryl did you take? I had a similar horrible experience at a 50mg dose which lasted over 24 hours, but at only 12.5mg it had almost the opposite effect.
The Last Psychiatrist wrote an article on the pharmacology of Benadryl, which explains that at different doses it doesn't just have different strengths, but acts as a totally different drug:
The Last Psychiatrist: Treating Insomnia With LessThe drug has the most affinity for H1 receptors, sure, but look what else it does. M1 blockade (dry mouth, constipation, confusion.) It also has significant NE and serotonin reuptake blockade. Basically, the FDA decided to pick only one of these four properties and slap it on the box, in the same way as labeling a TV dinner as "Rice."
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