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How adrenochrome works - it is a potent oxidizer/quinone and serotonin antagonist
- Thread starter haidut
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Michael Mohn
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I noticed that another metabolite of adrenaline is also very beneficial: Vanillic acid.
I found vanilla has a very profound anti stress effect and I thought that Vanillic acid in Vanilla signals the body the end of a stress response.
Badger
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Watch the 15 minute video collage of clips from Hollywood films referring to Adrenochrome use and harvesting blood from children to make it. Absolutely astounding. Had no idea so many films semi-transparently referring to or implying it:
Great post, sir. We know that one of the great benefits of a proper human diet and effective supplementation is the anti-aging effects. Ray posted his own before and after photos of utilizing Pregnenolone and that made me a believer.As most of my readers know, the topic of adrenochrome is perhaps one of the most controversial in both politics and medicine, due to its purported harvesting from children and usage for anti-aging purposes, as well as due to its purported role in causing schizophrenia and a number of other mental disorders.
Adrenochrome - Wikipedia
Interestingly, despite enjoying almost equal popularity and controversy with LSD back in the middle of the 20th century, official publications on adrenochrome all but disappeared and it became more of an urban legend as a chemical used by the elite to delay/reverse aging. Putting the scary stories about its harvesting aside, it looks like adrenochrome may indeed be a legit anti-aging remedy. First, it is a powerful oxidizing agent, with its quinone-like structure arranged so that its carbonyl groups are in the 2,3-position, or in other words an ortho-quinone. A number of recent studies have demonstrated that ortho-quinones have much stronger effects as oxidizing agents, compared to para-quinones or even less potent oxidizing agents where the carbonyl groups are in a different geometrical shapes). Case in point, the molecule 2,3-naphthoquinone (2,3-NQ) is currently considered the most potent among the naphtho-, benzo- and anthra- types of quinones, and adrenochrome is structurally very similar, with the same carbonyl arrangements as 2,3-NQ. In other words, adrenochrome is a powerful stimulant of oxidative metabolism.
2,3-Naphthoquinone
The anti-cancer molecule beta-lapachone is also an ortho-quinone and Dr. William Koch stated multiple times in his writings that the ortho-quinones such as beta-lapachone that he extracted from the bark of the Pau D'Arco tree were his preferred agents for not only treating cancer but increasing vitality and systemic health. The fact that adrenochrome decreases the decarboxylation of glutamic acid, as per the study below, suggests that it has an effect similar to vitamin K (another potent quinone, albeit in the para-configuration, with known benefits for health and lifespan). In addition, apparently adrenochrome is also a potent non-selective serotonin antagonist and, as such, was the basis for the development of the synthetic drug Iprazochrome.
Iprazochrome - Wikipedia
"...Chemically, it is a derivative of adrenochrome, which is a product of adrenaline oxidation. And it is a derivative of carbazochrome as well."
We already know that serotonin antagonists are capable of extending maximum lifespan by 30%-40% percent, which is way beyond what caloric restriction can achieve. Interestingly, a number of high-profile LSD-users advocated back in the 1960s and 1970s usage of LSD not only for its psychedelic effects but also due to its health benefits (in lower doses). These beneficial effects were a major reason why eventually Big Pharma got involved and developed several non-hallucinogenic LSD derivatives (bromocriptine, cabergoline, nicergoline, methysergide, metergoline, lisuride, etc) for official use as (expensive) clinical drugs.
Increasing serotonin (5-HT) breakdown delays/prevents aging
The naked mole rat (NMR) is one of the most fascinating species. Despite being a humble rodent, much smaller than a regular house/city rat, the NMR has an exceptionally long life-span of 35+ years (compared to 2-3 years for the common rat) and on top of that is remarkably resistant to the...raypeatforum.com
Serotonin Antagonists Extend Lifespan, SSRI Dramatically Shorten It
This study looked specifically at mianserin, but did compare it to other drugs (including cyproheptadine). The conclusion was that mianserin and cyproheptadine extend lifespan by up to 30% by mimicking the effects of caloric restriction. Interestingly, mianserin increases appetite just like...Blocking Serotonin Extends Lifespan By 40%, Triples Youthspan
The amazing effects of blocking serotonin just keep piling on. I posted a study some time ago showing that anti-serotonin drugs like mianserin and cyproheptadine extended lifespan by 30%-40% while serotonergic drugs like SSRI shortened lifespan by as much as 80%! viewtopic.php?f=178&t=6451 Now...
So, the urban legend may turn out to be true as there are several solid biochemical reasons to use adrenochrome as an anti-aging remedy. These effects of adrenochrome also directly call into question the official recommendations to lower metabolic rate and increase serotonin, as a methods for improving health and increasing lifespan. Now, since the general public has no interest in harvesting adrenochrome, something more benign such as a combination of vitamin K and famotidine/cyproheptadine/Benadryl, or maybe even just the drug Iprazochrome mentioned above, would probably suffice to replicate the effects of adrenochrome.
Über die antagonistische Wirkung des Adrenochroms auf Serotonin an glattmuskeligen Organen - The Science of Nature ("On the antagonistic effect of adrenochrome on serotonin in smooth muscle organs")
https://cl-pdx.com/static/1962_Effect_of_Adrenochrome_and_Adrenolutin.pdf
"...Adrenochrome markedly inhibits decarboxylation of glutamic acid in brain tissue (Holtz and Westermann, 1956), oxidizes simple amino acids, and is polymerized to brownish melanin pigments in brain, intestinal mucosa, and skin. It is an antagonist of serotonin (Stern et al., 19.56). However, its action is not always inhibitory or toxic. Derouaux and Roskam ( 1949) found that sympathetic nerves in the rabbit's ear did not fatigue as rapidly in the presence of adrenochrome. On the other hand Marrazzi ( 1957) and Hart et al. ( 1956) reported adrenochrome inhibited synaptic transmission as did epinephrine. "
Your post makes me think of the possible anti-aging effects of quinones when applied topically to the skin. What about a mix of Vitamin K, Metergoline, and Lisuride in a Tocopherol base? If methylene blue didn't make us look like Smurfs, I would add that too.
A certain cosmetics company could release such a product.
It appears that patents have already been filed for lapachol-containing skin/hair products.....
How do they patent a natural substance?
"Cosmetic compositions containing quinones and their topical use on skin and hair."
"Cosmetic composition for reducing skin wrinkle comprising lapachol"
How do they patent a natural substance?
"Cosmetic compositions containing quinones and their topical use on skin and hair."
WO2019213494A1 - Cosmetic compositions containing quinones and their topical use on skin and hair - Google Patents
Described are compositions containing quinones that show activity in enhance DNA repair and/or prevent damage to DNA and/or upregulate genes associated with wound healing. The quinones are thymoquinone, lapachol, myrtucommulone C, or mixtures thereof, and can be formulated into cosmetic...
patents.google.com
"Cosmetic composition for reducing skin wrinkle comprising lapachol"
KR20110115719A - Cosmetic composition for reducing skin wrinkle comprising lapachol - Google Patents
The present invention relates to a topical composition and cosmetic composition for promoting collagen biosynthesis using rapacol as an active ingredient, and the composition promotes collagen synthesis, thereby alleviating skin wrinkles and maintaining firmness and elasticity. Can be obtained.
patents.google.com
ddjd
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New idealabs product "Adreno-gin" or "Chroma-cet"?
OP
Yep, so applying vitamin K dissolved in oil (we have Kuinone in olive oil) would be a good approximation to those patents with lapachol/lapachone (also naphthoquinones like vitamin K). There is a company that did the studies with methylene blue (MB) reversing aging in human skin cells and they capitalized on that research by releasing a MB creme.
Bluelene - Revolutionary Methylene Blue Anti-Aging Skin Cream
Bluelene is the first commercially available skin cream with methylene blue for anti-aging. Scientifically proven to increase skin hydration, expand skin thickness, and improve overall skin texture. Shop now!
bluelene.com
BobbyJackson
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What do you think about using MB to get rid of lipofuscin?
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