Travis
Member
- Joined
- Jul 14, 2016
- Messages
- 3,189
Sure, but...
...[⁈]...by regulating the cytokine gamma-interferon...
Last edited:
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...[⁈]...by regulating the cytokine gamma-interferon...
We know that INF-y induces transcription of the cyclooxygenase genes, but there is also evidence that aspirin inhibits serine and tyrosine phosphorylation of STATs 1-3, and possibly STATs 4-6, which may explain why low-dose aspirin reduces COX-2 inflammatory activity slightly more than is explained by its pharmacokinetics.Sure, but......[⁈]
I think the reluctance to publish anything on the ammonia->cancer link is strongly influenced by the fear of implicating NO as harmful. The doctors were right, entire branches of medicine rest on the assumption that NO is beneficial and tons of money are ties to NO-boosting drug sales.
Yes, histamine is a big issue with aged anything. Even cheeses. Also, aged meat has a lot of endotoxin as even a lot of salt will not completely stop bacteria from metabolizing some of it.
That's H2.But Histamine is involved with gastric acid release...
Gastric acid release[edit]
Enterochromaffin-like cells, located within the gastric glands of the stomach, release histamine that stimulates nearby parietal cells by binding to the apical H2 receptor. Stimulation of the parietal cell induces the uptake of carbon dioxide and water from the blood, which is then converted to carbonic acid by the enzyme carbonic anhydrase. Inside the cytoplasm of the parietal cell, the carbonic acid readily dissociates into hydrogen and bicarbonate ions. The bicarbonate ions diffuse back through the basilar membrane and into the bloodstream, while the hydrogen ions are pumped into the lumen of the stomach via a K+/H+ ATPase pump. Histamine release is halted when the pH of the stomach starts to decrease. Antagonist molecules, like ranitidine, block the H2 receptor and prevent histamine from binding, causing decreased hydrogen ion secretion. - Wikipedia
But Histamine is involved with gastric acid release...
Gastric acid release[edit]
Enterochromaffin-like cells, located within the gastric glands of the stomach, release histamine that stimulates nearby parietal cells by binding to the apical H2 receptor. Stimulation of the parietal cell induces the uptake of carbon dioxide and water from the blood, which is then converted to carbonic acid by the enzyme carbonic anhydrase. Inside the cytoplasm of the parietal cell, the carbonic acid readily dissociates into hydrogen and bicarbonate ions. The bicarbonate ions diffuse back through the basilar membrane and into the bloodstream, while the hydrogen ions are pumped into the lumen of the stomach via a K+/H+ ATPase pump. Histamine release is halted when the pH of the stomach starts to decrease. Antagonist molecules, like ranitidine, block the H2 receptor and prevent histamine from binding, causing decreased hydrogen ion secretion. - Wikipedia
So am I to understand that my love affair with bacon and hot dogs could be contributing to my ongoing battle with sleep issues? ( I can only sleep for two or three hours at a time at random times of the day and night.)
So am I to understand that my love affair with bacon and hot dogs could be contributing to my ongoing battle with sleep issues? ( I can only sleep for two or three hours at a time at random times of the day and night.)