Johnson Bagfoot
Member
- Joined
- Jun 21, 2017
- Messages
- 104
I've had long term chronic fatigue, anxiety, insomnia - starting during 8 years on SSRIs and worsening significantly during discontinuation. Also, typical hypothyroid symptoms of low temperature, low pulse, although a reasonable TSH of 2.5.
One key finding this week was that my 8am peak cortisol is very low.
I had previously tried mirtazapine and cyproheptadine. Both of them made me feel far worse, mirtazapine worsened my sleep and morning anxiety, while cyproheptadine significantly lowered my already low pulse down to 40 or so and dropped my temps down to high 94s. However, cypro was definitely quite calming aside from the super slowed down metabolic rate.
In another experience a while ago, I also found psychedelic mushrooms (serotonin antagonist / or competitors) extremely calming in a similar way to cypro.
I'd like to try something with effects limited to being a serotonin antagonist, but without any effect on cortisol, since it should be raised if anything. Could anyone point me towards any pharmaceuticals with desirable mechanisms of action? Maybe another anti-histamine that doesn't blunt cortisol like cypro?
Johnson
One key finding this week was that my 8am peak cortisol is very low.
I had previously tried mirtazapine and cyproheptadine. Both of them made me feel far worse, mirtazapine worsened my sleep and morning anxiety, while cyproheptadine significantly lowered my already low pulse down to 40 or so and dropped my temps down to high 94s. However, cypro was definitely quite calming aside from the super slowed down metabolic rate.
In another experience a while ago, I also found psychedelic mushrooms (serotonin antagonist / or competitors) extremely calming in a similar way to cypro.
I'd like to try something with effects limited to being a serotonin antagonist, but without any effect on cortisol, since it should be raised if anything. Could anyone point me towards any pharmaceuticals with desirable mechanisms of action? Maybe another anti-histamine that doesn't blunt cortisol like cypro?
Johnson