General Orange
Member
Is it unnecessary to take vitamin K with aspirin? It is nonsense ?
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Interesting. So, it would seem topical and oral would cover all the bases.I find this substantial as well, because the MK4 supplement I am taking is only designed for external (topical) use, which does not seem to be the best delivery for the substance
I see references all around about Peat saying to take vitamin K to offset aspirins thinning of the blood. However, it never says Vitamin K1 or K2, it just says Vitamin K. I see people saying they take Vitamin K2, but I thought K2 was more for bone health, and K1 is more for clotting factor. So which one is Ray Peat referring to when he says to take some vitamin K along with aspirin? And how much should be taken? Is there a correct ratio to try for? Is there any signs that show up if you are not getting enough K with your Aspirin? Maybe like bloody noses or something....
I had in mind the 500 mcg of K1 and 150 mcg of MK-4 batch that we talked about before, but it's up to you to separate them or not. You already asked your supplier..You mean K1 separately or mixed with MK-4?
I had in mind the 500 mcg of K1 and 150 mcg of MK-4 batch that we talked about before, but it's up to you to separate them or not. You already asked your supplier..
What if I die? Will you at least be present at the funeral?You don't think 500mcg K1 would be a bit too much and maybe risk a clot event? I would have thought the opposite ratio would be better - 500mcg MK-4 and 150mcg K1.
I can make a bottle for you and if you really like it then you can share your story and we can make it into a separate product for everybody.
What if I die? Will you at least be present at the funeral?
I was thinking of waiting for others' deaths first, and if none was reported, I could then try.
Here they used up to 2000 mcg without such (†) events:
A high phylloquinone intake is required to achieve maximal osteocalcin γ-carboxylation
I never tried K1 before, so I'm willing to for the sake of curiosity, I volunteer.
I already has your K2, so just K1 initially will make it easier to note its effects, it will also simplify for you. Why 300 mcg?OK, so I will try to make a solution with K1:MK-4 in a 3:1 ratio. Probably 300mcg K1 and 100mcg MK-4 per drop.
I already has your K2, so just K1 initially will make it easier to note its effects, it will also simplify for you. Why 300 mcg?
As commented on the previous page, if I were to sell such supplement, I would put 500 mcg of K1 per serving that requires 3 (or 2) drops; so it's matching what you have in mind.To lower risk of accidental overdose. If it has say 1mg+ per drop it is quite easy to put a few milligrams too many on the skin or ingest them accidentally.
As commented on the previous page, if I were to sell such supplement, I would put 500 mcg of K1 per serving that requires 3 (or 2) drops; so it's matching what you have in mind.
That's why I commented before that it must be preferable to leave for K1 what it can do best, covering the basics with it, and then adding the freed Mk-4 as needed. The experiments that used higher doses (up to 135 mg/d) opened new possibilities, but encouraged visible mass overdosing.I have performed quite a few tests with high dose K2, be careful for oxidative damage signs. I know what it should do, sometimes less is more, especially in delicate situations. Ditto your vit D supplementation, in my experience and observation, a lot of 'kidney patients' do badly on supplemental D. I suspect, but am not sure, that the added calcium uptake it encourages doesn't get used properly and does what it shouldn't according to theory.
Vitamin K1 is the one with clotting properties, and that's the one you'd want to take with aspirin.
Vitamin K2 has other properties. MK4 is absorbed immediately, while MK7 stays in the liver and is used as needed over a longer period of time.