David Sinclair talking about how to extend lifespan. I've seen him making the rounds on the interview circuit (Joe Rogan, Google Talks, etc.) over the past year or so. It looks like he's been getting quite a bit of attention.
9:19 - "Well the clock of aging is due to the loss of information in the cell, and one way to accelerate that is to go break a chromosome. Instead of going in the sun, we've engineered a mouse where we could break its chromosomes. Not enough to cause mutations (the cells put the DNA back together), so we didn't lose any genetic information, but if we're right about the epigenetic information theory of aging, those mice should get old, and that's exactly what happened. Its gray, its got a hunchback, its got dementia, all its organs look old."
12:22 - "The mouse experiments bear this out. The best way to make a mouse live longer is to restrict the time that it eats (so, periodic fasting), to keep it a little cool, and to restrict its amino acids. That's the recipe for long life for a mouse. And it's true for monkeys as well. There have been calorie-restricted studies where these monkeys for 15 years didn't eat as much food as ones that gorged themselves whenever they wanted, and they were protected. They didn't just age slower, they didn't get as much diabetes and heart disease. They were actually fit and healthy.."
The line about the amino acids made me smile. Maybe soon Sinclair will catch up to where Peat was 20 years ago with his view on amino acids and specifically which ones accelerate aging and/or can extend lifespan.
I'm curious if anyone here on the forum has done the Horvath biological clock test?
9:19 - "Well the clock of aging is due to the loss of information in the cell, and one way to accelerate that is to go break a chromosome. Instead of going in the sun, we've engineered a mouse where we could break its chromosomes. Not enough to cause mutations (the cells put the DNA back together), so we didn't lose any genetic information, but if we're right about the epigenetic information theory of aging, those mice should get old, and that's exactly what happened. Its gray, its got a hunchback, its got dementia, all its organs look old."
12:22 - "The mouse experiments bear this out. The best way to make a mouse live longer is to restrict the time that it eats (so, periodic fasting), to keep it a little cool, and to restrict its amino acids. That's the recipe for long life for a mouse. And it's true for monkeys as well. There have been calorie-restricted studies where these monkeys for 15 years didn't eat as much food as ones that gorged themselves whenever they wanted, and they were protected. They didn't just age slower, they didn't get as much diabetes and heart disease. They were actually fit and healthy.."
The line about the amino acids made me smile. Maybe soon Sinclair will catch up to where Peat was 20 years ago with his view on amino acids and specifically which ones accelerate aging and/or can extend lifespan.
I'm curious if anyone here on the forum has done the Horvath biological clock test?