The puzzle begins to take shape.
As I wrote in the thread,High salt intake caused metabolic acidosis, I assume that ADHD may be a simple dopamine deficiency.
As you can see from the diagram below, vitamin B6 is essential for the synthesis of dopamine.
Haidut previously published a study in which ADHD was successfully treated with B6.
[URL Unfurl = "true"] ADHD may be simply a vitamin B6 deficiency symptom [/ URL]
The diagram shows that iron is necessary for the conversion of phenylalanine to tyrosine, and then to l-dopa (I think if someone does not help L-dopa - the problem is a lack of B6).
This study showed the effectiveness of iron supplementation in ADHD.
Also from this diagram, we can see that dopamine is further converted to norepinephrine by copper and vitamin C. Based on this, I assume that an excess of copper in sensitive brain tissues can lead to a strong conversion of dopamine to norepinephrine and a deficiency of dopamine.
In this thread(Excess Copper), a formula for calculating free copper was previously published. I turned out to have 27, which is almost 2 times higher than the expected norm. Itis the excess of free copper that can accumulate in the tissues. I have also previously noticed brown spots from copper additives. I think it might be related.
It is known that estrogen causes the accumulation of copper in the tissues and vice versa.
This study found low levels of vitamin A and D in children with ADHD:
And in this topic, Haidut provided a study that links low vitamin D levels to high estrogen levels:
In this study, it was shown that vitamin A causes a strong increase in the synthesis of cerruloplasmin:
B12 levels are inversely proportional to the severity of ADHD symptoms:
B12 deficiency causes copper deficiency:
I think that B12 is necessary for the synthesis of cerruloplasmin and if you do not have enough b12 there will be little cerruloplasmin, but a lot of free copper that will be excreted in the urine/accumulate in the tissues, which will cause a deficiency. But there is little information on this topic, and here you may not believe me.
I also recommend taking into account the information from this thread. If there is hypothyroidism, it will cause a B12 deficiency, so treating hypothyroidism, if there is one, is probably one of the priorities.
Therefore, I believe that a set of different factors that reduce dopamine, such as iron/B6 deficiency, excess estrogen/free copper (due to low intake or retinol/B12 deficiency) collectively or individually causes ADHD. Hence, B6, A, B12 supplements and dietary restriction of copper seem to me to be potentially useful in the treatment of ADHD. Anything that inhibits aromatase and lowering estrogen levels, such as zinc or caffeine, can also be useful.
As I wrote in the thread,High salt intake caused metabolic acidosis, I assume that ADHD may be a simple dopamine deficiency.
As you can see from the diagram below, vitamin B6 is essential for the synthesis of dopamine.
Haidut previously published a study in which ADHD was successfully treated with B6.
[URL Unfurl = "true"] ADHD may be simply a vitamin B6 deficiency symptom [/ URL]
The diagram shows that iron is necessary for the conversion of phenylalanine to tyrosine, and then to l-dopa (I think if someone does not help L-dopa - the problem is a lack of B6).
Effects of iron supplementation on attention deficit hyperactivity disorder in children - PubMed
Iron deficiency has been suggested as a possible contributing cause of attention deficit hyperactivity disorder (ADHD) in children. This present study examined the effects of iron supplementation on ADHD in children. Twenty-three nonanemic children (aged 5-8 years) with serum ferritin levels <30 …
pubmed.ncbi.nlm.nih.gov
Also from this diagram, we can see that dopamine is further converted to norepinephrine by copper and vitamin C. Based on this, I assume that an excess of copper in sensitive brain tissues can lead to a strong conversion of dopamine to norepinephrine and a deficiency of dopamine.
In this thread(Excess Copper), a formula for calculating free copper was previously published. I turned out to have 27, which is almost 2 times higher than the expected norm. Itis the excess of free copper that can accumulate in the tissues. I have also previously noticed brown spots from copper additives. I think it might be related.
It is known that estrogen causes the accumulation of copper in the tissues and vice versa.
This study found low levels of vitamin A and D in children with ADHD:
Frontiers | Serum Levels of Vitamin A and Vitamin D and Their Association With Symptoms in Children With Attention Deficit Hyperactivity Disorder
Objective: To measure levels of vitamin A (VA) and vitamin D (VD) and the symptomatic association of their co-deficiencies on attention deficit hyperactivity...
www.frontiersin.org
And in this topic, Haidut provided a study that links low vitamin D levels to high estrogen levels:
High Estrogen (Androgen Deficiency) Causes Low Vitamin D; DHT Is Therapeutic
I rarely stumble across studies like this one. Namely, showing in one single experiment both the detrimental effects of estrogen on one of the most important biomarkers of health (vitamin D), and the beneficial effects of a steroid long vilified/demonized by virtually everybody wearing a white...
raypeatforum.com
In this study, it was shown that vitamin A causes a strong increase in the synthesis of cerruloplasmin:
Induction of ceruloplasmin synthesis by retinoic acid in rats: influence of dietary copper and vitamin A status - PubMed
Ceruloplasmin, a copper-containing acute phase plasma protein, has been shown to be regulated by 13-cis retinoic acid in rats. Ceruloplasmin activity was significantly increased within 24 h and remained elevated for at least 72 h after a single injection of 13-cis retinoic acid. With daily...
pubmed.ncbi.nlm.nih.gov
B12 levels are inversely proportional to the severity of ADHD symptoms:
B12 deficiency causes copper deficiency:
Hypocupremia associated with prior vitamin B12 deficiency - PubMed
Clinical similarities between vitamin B(12) and copper deficiencies prompted us to investigate if hypocupremia is present in patients receiving vitamin B(12) supplementation. Our pilot study results indicate that a significant number of elderly patients with prior diagnosis of vitamin B(12)...
pubmed.ncbi.nlm.nih.gov
B12 Deficiency And Hypothyroidism
I'm posting this because I don't think I've seen much information about it that sounded imperative. B12 is mentioned a lot for energy, but I've been Peating for over a year and I am just learning that one of the most serious complications of hypothyroidism is a B12 deficiency...
raypeatforum.com
Therefore, I believe that a set of different factors that reduce dopamine, such as iron/B6 deficiency, excess estrogen/free copper (due to low intake or retinol/B12 deficiency) collectively or individually causes ADHD. Hence, B6, A, B12 supplements and dietary restriction of copper seem to me to be potentially useful in the treatment of ADHD. Anything that inhibits aromatase and lowering estrogen levels, such as zinc or caffeine, can also be useful.
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