hi, i have quite high b12 (550 pmol) without any supplementation. I struggle to understand the bio jargon of the studies above, how could this mean I have a functional deficiency?
does anyone know how b12 is associated with red blood cells? I have very high red cell count, along with very low mean corpuscular volume (MCV), and high red cell distribution width (RDW). High RDW and normal MCV show a deficiency in iron or B12, but low MCV shows i have the thalassemia trait, which results in microcytic anemia (supposed to have lower hemoglobin but mine is normal).
This is where my research hits a wall. Im trying to find if theres a connection between the overproduction of red blood cells, or the higher width or smaller volume, and some vitamin deficiency (possibly b12 since mine is elevated). In one of the papers above it cited the high serum cobalamin due to 'Polycythemia vera', which is a blood disorder that also has a very high red blood cell count, making me think of the possible connection. (pathophysiology of elevated vitamin B12 in clinical practice)
Im slightly hypo with cold extremities, slow pulse and severe chronic hair shedding, have fixed my diet etc, my ferritin is normal.
does anyone know how b12 is associated with red blood cells? I have very high red cell count, along with very low mean corpuscular volume (MCV), and high red cell distribution width (RDW). High RDW and normal MCV show a deficiency in iron or B12, but low MCV shows i have the thalassemia trait, which results in microcytic anemia (supposed to have lower hemoglobin but mine is normal).
This is where my research hits a wall. Im trying to find if theres a connection between the overproduction of red blood cells, or the higher width or smaller volume, and some vitamin deficiency (possibly b12 since mine is elevated). In one of the papers above it cited the high serum cobalamin due to 'Polycythemia vera', which is a blood disorder that also has a very high red blood cell count, making me think of the possible connection. (pathophysiology of elevated vitamin B12 in clinical practice)
Im slightly hypo with cold extremities, slow pulse and severe chronic hair shedding, have fixed my diet etc, my ferritin is normal.
Last edited: