Long (230 day) Covid

[Mito]

SARS-CoV-2 infection and persistence throughout the human body and brain​

Abstract​

COVID-19 is known to cause multi-organ dysfunction1-3 in acute infection, with prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 (PASC)4-5. However, the burden of infection outside the respiratory tract and time to viral clearance is not well characterized, particularly in the brain3,6-14. We performed complete autopsies on 44 patients with COVID-19 to map and quantify SARS-CoV-2 distribution, replication, and cell-type specificity across the human body, including brain, from acute infection through over seven months following symptom onset. We show that SARS-CoV-2 is widely distributed, even among patients who died with asymptomatic to mild COVID-19, and that virus replication is present in multiple extrapulmonary tissues early in infection. Further, we detected SARS-CoV-2 RNA in multiple anatomic sites, including regions throughout the brain, for up to 230 days following symptom onset. Despite extensive distribution of SARS-CoV-2 in the body, we observed a paucity of inflammation or direct viral cytopathology outside of the lungs. Our data prove that SARS-CoV-2 causes systemic infection and can persist in the body for months.

SARS-CoV-2 infection and persistence throughout the human body and brain

COVID-19 is known to cause multi-organ dysfunction1-3 in acute infection, with prolonged symptoms experienced by some patients, termed Post-Acute Sequelae of SARS-CoV-2 (PASC)4-5. However, the burden of infection outside the respiratory tract and time to viral clearance is n...

www.researchsquare.com

 

[Kayaker]

This study suggests brain fog in long covid is from lower respiratory function.

 

[Perry Staltic]

We performed complete autopsies on 44 patients with COVID-19.... Despite extensive distribution of SARS-CoV-2 in the body, we observed a paucity of inflammation or direct viral cytopathology outside of the lungs.

So that means 44 patients were almost certainly intubated. How do they know the inflammation and pathology was caused by the virus and not by mechanical ventilation? They don't. No viral cytopathology observed outside the lungs suggests that the pathology observed in the lungs was not viral in nature.

 

[Kayaker]

So that means 44 patients were almost certainly intubated. How do they know the inflammation and pathology was caused by the virus and not by mechanical ventilation? They don't. No viral cytopathology observed outside the lungs suggests that the pathology observed in the lungs was not viral in nature.

It says they died with asymptomatic or mild COVID-19. I assume they died from other things and were found to still have it post-mortem.

 

[Perry Staltic]

It says they died with asymptomatic or mild COVID-19. I assume they died from other things and were found to still have it post-mortem.

Sounds like severe covid to me. 8 fewer intubated than I thought it would be.

Patients presented to the hospital a mean of 9.4 days following symptom onset and were hospitalized a mean of 26.4 days. Overall, the mean interval from symptom onset to death was 35.2 days and the mean postmortem interval was 26.2 hours. 81.8% of patients required intubation with invasive mechanical ventilation, 22.7% received extracorporeal membrane oxygenation (ECMO) support, and 40.9% required
renal replacement therapy.

 

[ddjd]

I personally would try antihistamines


View: https://twitter.com/julesserkin/status/1542127749481078785?t=kr3ahrCvbjn4UXVNqxd8Eg&s=19