Central Serous Retinopathy / (Piracetam/Pregnenolone/TRT/Cortison)

[Bizzactiondrive]

Hi Everyone!

I was diagnosed with a rare eye condition of the retina called Central Serous Retinophaty.

I went to the doc because my left eye started some to create blurry visions at small distance and some kind of 3D optic on further distance.

The doctor diagnosted it. And told me reason is stress, it will heal in 3-6 probably from it owne.

I should start to meditate and cut my Cortisol Nosespray which i was using for chronic sinusitis.

Im indeed in a terrible stressfull situation right now which im trying to relieve(Job+Private/Combinated in home office)
Also overdid it with alcohol
And took the following supplements:
Highdose Piracetam 3x Daily 4,8g
Pregnenolone 6,25mg Mo-Fr
2times Dimysta Nosespray daily
Selfdescribed TRT 200mg weekly (EOD)
5mg Cialis daily

I instantly stopped everything except the TRT which i cut down to 150mg weekly.

Can you give me some advice about Pregnenolone,Cialis and Piracetam?

Thanks Br

 

[S-VV]

What testosterone ester? In what oil? UG lab or pharma? And did you take an AI with it?

 

[Bizzactiondrive]

Enanthate / Dont know the oil / UGL/AI Aromasin but just occasionally as i thought e2 went to high.

 

[Hans]

Hi Everyone!

I was diagnosed with a rare eye condition of the retina called Central Serous Retinophaty.

I went to the doc because my left eye started some to create blurry visions at small distance and some kind of 3D optic on further distance.

The doctor diagnosted it. And told me reason is stress, it will heal in 3-6 probably from it owne.

I should start to meditate and cut my Cortisol Nosespray which i was using for chronic sinusitis.

Im indeed in a terrible stressfull situation right now which im trying to relieve(Job+Private/Combinated in home office)
Also overdid it with alcohol
And took the following supplements:
Highdose Piracetam 3x Daily 4,8g
Pregnenolone 6,25mg Mo-Fr
2times Dimysta Nosespray daily
Selfdescribed TRT 200mg weekly (EOD)
5mg Cialis daily

I instantly stopped everything except the TRT which i cut down to 150mg weekly.

Can you give me some advice about Pregnenolone,Cialis and Piracetam?

Thanks Br

Piracetam and pregnenolone are very safe and should not be an issue if you continue to use it. They should even help.
I can only imagine that the cortisol nose spray contributed significantly to your issue. Cortisol is very catabolic, so over time could definitely cause issues.

The best thing I've done for my eyes is to get at least 30minutes of bright sunlight daily. Works great. Also, red light has been shown to improve eye health.

Gut issues can also contribute to eye degeneration. Leaky gut, endotoxins, immune responses, etc., can greatly increase inflammation. Alcohol and stress are known to cause gut dysbiosis and leaky gut.

 

[Bizzactiondrive]

Hi Hans.

At first thanks for taking time fir the feedback.

As for the cortisol spray there is absolutely no doubt.

As for alcohol also.

What matters is that at my disease they count as some risk factors high cortisol levels and extern use of glucocorticoide.

Im also suffering at GERD. Which some Resources also link a connection to the outbreak of the retina disease.

As for Pregnenolone, i ask myself since longer period of time about which impact it has on cortison.
+ I read that the precursor from glucocorticoide, which is a risk factor, is progesterone.
And that small dosages of pregnenolone mostly turn to progesterone.
So im very unsure if that was also an impact for this.

As for future what supplements would you recommend?
Like i said right now im at selfprescribed TRT 150mg weekly + additional take Ashwaghanda Extract 600mg + 400mg L-Theanine + Two Times 400mg Magnesium + 3 times Meditation and focusing at eliminating every emotional stress.

Read about adding High Dose Antioxidants + Lutein.

Whats your opinion about oxygen and bloodflow promoting supplements now like cialis,piracetam and citrulin malat?

 

[Bizzactiondrive]

Also how can i tackle possible gut issues?

Because honestly my stool is very very soft since a long time

 

[Hans]

Hi Hans.

At first thanks for taking time fir the feedback.

As for the cortisol spray there is absolutely no doubt.

As for alcohol also.

What matters is that at my disease they count as some risk factors high cortisol levels and extern use of glucocorticoide.

Im also suffering at GERD. Which some Resources also link a connection to the outbreak of the retina disease.

As for Pregnenolone, i ask myself since longer period of time about which impact it has on cortison.
+ I read that the precursor from glucocorticoide, which is a risk factor, is progesterone.
And that small dosages of pregnenolone mostly turn to progesterone.
So im very unsure if that was also an impact for this.

As for future what supplements would you recommend?
Like i said right now im at selfprescribed TRT 150mg weekly + additional take Ashwaghanda Extract 600mg + 400mg L-Theanine + Two Times 400mg Magnesium + 3 times Meditation and focusing at eliminating every emotional stress.

Read about adding High Dose Antioxidants + Lutein.

Whats your opinion about oxygen and bloodflow promoting supplements now like cialis,piracetam and citrulin malat?

GERD is most likely due to low stomach acid, so I'd focus on addressing that. Betaine HCL, salt, bitters (e.g. gentian) and niacin can help to improve stomach acid release.
I've never seen a case where pregnenolone supplementation skyrockets cortisol. On the contrary, pregnenolone can help to keep cortisol in check as it's somewhat of an adaptogen as well. Progesterone itself has potent anti-cortisol effects. Large doses of pregnenolone will quickly increase progesterone. Or many you can try a mix of progesterone and DHEA.

I'd focus mainly on the gut. Optimizing stomach acid is a good start. Then you'd want to fix leaky gut and lower gut inflammation. For that, stress management (which you're already doing), micronutrients (e.g. zinc) and anti-microbials are is a good start.
Try to get all your micronutrients from animal sources, such as organ meat, shellfish, eggs, milk, honey, etc.
Calm gut inflammation with Iberogast or an anti-inflammatory herb, such as Boswellia.
Try a few supplements that can restore the gut lining, such as bone broth, glutamine, orange juice, etc.

Not sure if high dose anti-oxidants + lutein is necessary. Perhaps rather something like blueberries or blueberry extract, which is great for lowering inflammation in the gut.

For blood flow promoters, I'd rather focus on restoring it indirectly, such as by lowering oxidative stress, as free radicals can lower eNOS and lower NO production. Piracetam is great though, since it improves cellular function in the whole body.

 

[Bizzactiondrive]

Hey!
Incredible detailed.

But how can i go sure that my gerd is low stomac acic related.
I have also inflamation of the esophagus.
And my primary symptoms have been coughing, forced throat and throat pain.

The high dose antioxidants(c+e+beta carodine+zink+selenium)+lutein is linked to an study to heal the CSR faster.

Also what microbials do you recommend and what do you think about adding probiotics and bentonit?

 

[Hans]

Hey!
Incredible detailed.

But how can i go sure that my gerd is low stomac acic related.
I have also inflamation of the esophagus.
And my primary symptoms have been coughing, forced throat and throat pain.

The high dose antioxidants(c+e+beta carodine+zink+selenium)+lutein is linked to an study to heal the CSR faster.

Also what microbials do you recommend and what do you think about adding probiotics and bentonit?

If you're getting GERD about 30min+ after a meal, then it's most likely low stomach acid. If your value is not closing enough, then it has probably nothing to do with your stomach acid, but that your stomach acid is burning the esophagus and creating inflammation. The value weakness can also be due to chronic high cortisol.
You can always try the high dose anti-oxidants, but I'm sure the majority of the benefits are from the vitamins and minerals.

A few good anti-microbials with anti-inflammatory properties are black cumin seed powder, pau d arco, willow bark extract, uva ursi, Ceylon cinnamon, etc.

The probiotics and benotine clay might be helpful if done right.

 

[tankasnowgod]

Piracetam and pregnenolone are very safe and should not be an issue if you continue to use it. They should even help.
I can only imagine that the cortisol nose spray contributed significantly to your issue. Cortisol is very catabolic, so over time could definitely cause issues.

The best thing I've done for my eyes is to get at least 30minutes of bright sunlight daily. Works great. Also, red light has been shown to improve eye health.

Gut issues can also contribute to eye degeneration. Leaky gut, endotoxins, immune responses, etc., can greatly increase inflammation. Alcohol and stress are known to cause gut dysbiosis and leaky gut.

The only other thing I would add to this is to reduce blue light as well. If you don't have f.lux on your computer, I recommend it, if you spend a lot of time looking at a screen. I also change all the background on my devices to a solid red background. I certainly helps over time, using a computer is much easier on the eyes this way.

 

[Bizzactiondrive]

If you're getting GERD about 30min+ after a meal, then it's most likely low stomach acid. If your value is not closing enough, then it has probably nothing to do with your stomach acid, but that your stomach acid is burning the esophagus and creating inflammation. The value weakness can also be due to chronic high cortisol.
You can always try the high dose anti-oxidants, but I'm sure the majority of the benefits are from the vitamins and minerals.

A few good anti-microbials with anti-inflammatory properties are black cumin seed powder, pau d arco, willow bark extract, uva ursi, Ceylon cinnamon, etc.

The probiotics and benotine clay might be helpful if done right.

Whats the right way to get Probiotics and the clay done?

And which dosages of the acid supplements do you recommend?

 

[Bizzactiondrive]

The only other thing I would add to this is to reduce blue light as well. If you don't have f.lux on your computer, I recommend it, if you spend a lot of time looking at a screen. I also change all the background on my devices to a solid red background. I certainly helps over time, using a computer is much easier on the eyes this way.

Thanks for your input. Will definitely try that.

 

[Bizzactiondrive]

Also im somehow unsure because the typical stuff of what you read about CSR is dont take blood thinner.

But I dont understand why

 

[jmojo]

@Hans , do you have experience with Iberogast? I definitely have digestive issues (gas, bloating, slow emptying, constipation). Do you think it's worth a try? Is it safe?

 

[SOMO]

Pregnenolone and TRT causes blurry vision for me.

So does Methylene Blue.

High dose Progesterone also causes sedation and my eyes feel a bit "sleepy" when taking prog.

 

[Bizzactiondrive]

Pregnenolone and TRT causes blurry vision for me.

So does Methylene Blue.

High dose Progesterone also causes sedation and my eyes feel a bit "sleepy" when taking prog.

How long does this occur?

 

[SOMO]

How long does this occur?

For a few hours until they are excreted from the body.

I would think it was a fluke, but the effect is reproducible.

 

[ecstatichamster]

That’s a very unphysiological T dose. Aromatizes into estradiol. Why take so much. And at one time. Very bad idea.

 

[Bizzactiondrive]

That’s a very unphysiological T dose. Aromatizes into estradiol. Why take so much. And at one time. Very bad idea.

Like I said i take eod frequence.
And 200mg is at this frequence maybe slightly unphysiological, but als the range for what is physiological decreases.
Anyway cut down to 150mg which should edge around physiological levels eod.

 

[Bizzactiondrive]

For a few hours until they are excreted from the body.

I would think it was a fluke, but the effect is reproducible.

Sometimes when i took pregnenolone excessive. I got this feeling that my eyes get very wet, and i got somekinf of sad. But not not emotionsl bitchy sad like on high e2, so maybe this was prolactin releated.

I read articles about CSR condition about risk groups.
And even if men should be at primary risk, there is a mentioned risk for pregnant women.

So this, + precursor of cortisol + and of all corticosteroids really tells get me in the thinking that Preg/Prog can play a role in the devoloping of CSR.

Even if its like only in addition of taking a cortisol nosespray,alcohol and excessive stress.