Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial

[David PS]

Background: Dental caries is a worldwide challenge for public health. The aim of this 18-month double-blinded, randomized, clinical trial was to compare the caries-preventing effect of a fluoride-free, hydroxyapatite toothpaste (test) and a toothpaste with sodium fluoride (1450 ppm fluoride; positive control) in adults.

Methods: The primary endpoint was the percentage of subjects showing no increase in overall Decayed Missing Filled Surfaces (DMFS) index. The study was designed as non-inferiority trial. Non-inferiority was claimed if the upper limit of the exact one-sided 95% confidence interval for the difference of the primary endpoint DMFS between test and control toothpaste was less than the predefined margin of non-inferiority (Δ ≤ 20%).

Results: In total, 189 adults were included in the intention-to-treat (ITT) analysis; 171 subjects finished the study per protocol (PP). According to the PP analysis, no increase in DMFS index was observed in 89.3% of subjects of the hydroxyapatite group and 87.4% of the subjects of the fluoride group. The hydroxyapatite toothpaste was not statistically inferior to a fluoride toothpaste with regard to the primary endpoint.

Conclusion: Hydroxyapatite was proven to be a safe and efficient anti-caries agent in oral care.

Children are likely to swallow toothpaste, especially if it is sweetened to make it more "kid-friendly". A fluoride-free toothpaste containing Hydroxyapatite may be a better alternative for all ages.

Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial

BackgroundDental caries is a worldwide challenge for public health. The aim of this 18-month double-blinded, randomized, clinical trial was to compare the caries-preventing effect of a fluoride-free, hydroxyapatite toothpaste (test) and a toothpaste with sodium fluoride (1450 ppm fluoride...

www.frontiersin.org

 

[3slackC]

I switched to a hydroxyapatite containing toothpaste because I became sensitive to SLS and a friend pressured me into avoiding fluoride. Interesting study, which coincides with my own experience. I try to brush twice daily, actually brush once more often than not (lack of time in the morning) for 2-3 minutes. Dentist is impressed, my teeth are in great shape, just a little bit of plaque on them. He thinks I'm an expert at brushing and complimented my extensive oral care multiple times. I eat loads of sugar and sour fruit, but feel like my teeth have actually gotten less sensitive.

Using this if anyone cares: Bioniq® Repair-Zahnpflege International

 

[TheSir]

I wish they used a no toothpaste control group too. I've been brushing with a dry brush for the last few years - unsure if to my detriment or not.

 

[TheSir]

I switched to a hydroxyapatite containing toothpaste because I became sensitive to SLS and a friend pressured me into avoiding fluoride. Interesting study, which coincides with my own experience. I try to brush twice daily, actually brush once more often than not (lack of time in the morning) for 2-3 minutes.

Have you considered swishing the toothpaste for like 30 mins a day? I'd imagine that would be powerful, given that the paste doesn't have many harmful additivea.