tallglass13
Member
- Joined
- Dec 29, 2015
- Messages
- 840
Pretty decent . I actually would not argue this. Good Job. How do we get Epi up? And I definitely agree that low testosterone is implicated in balding, and even DHT> I have been taking 1-3mg DHT and feel very good.Estrogen is secondary in the whole story. It is protective against hair loss but the primary problem lies in the androgen cascade. Guys who have normal steroid metabolism in the follicle can run letrozole and roids like no man's business and their hair won't be affected. However for someone with MPB, losing their estrogen expression will add further insult to injury and make the whole thing progress even faster, because estrogen stimulates dermal papilla proliferation and upregulates a whole host of hair growth genes which are typically downregulated in the balding scalp.
A large factor in MPB is the epitestosterone (endogenous antiandrogen) being low in balding people and in their children (this seems to be genetic). So you have too much androgenic activity in the hair follicle, and this ratio gets worse with age. That defeats the "teenagers would lose their hair because they have the highest androgens" argument - they also have the highest antiandrogens as well.
Your testosterone & DHT also go down with age, but less. That contributes to the gut, manboobs and fat.
I think what is helpful here is to understand that the hair follicle has its own steroid metabolism, and that this is not necessarily reflective of what happens in the rest of the body.