Yes and he advises tiny bits of Cynomel. For example, taking about 1/6 of a Cynomel with food every several hours. Maybe getting only 1/2 pill a day for several weeks, then upping it very slowly. Otherwise, you can get jittery. You want the effect to be smooth.Those are pretty heavy starting doses. For comparison, Ray recommends starting with 1/8 of a Cynoplus, which is approximately 15mcg t4 and 4mcg t3.