First, as we show here, treatment with VK2 results in reduced androgen receptor expression. Previous studies have shown that the androgen receptor is essential for cell viability and proliferation of prostate cancer cells [38]. Another possible explanation for the reduction in cell viability noted with VK2 treatment is the inhibition of AKT activation. The AKT activation plays a central role in tumorigenesis, promoting cell growth and survival by suppressing apoptosis [39]. Previous studies suggest that AKT signaling may play a key role in prostate cancer progression, allowing cells to continue to proliferate in an androgen deprived state [40]. Increased AKT phosphorylation has also been associated with higher gleason grade, advanced stage and poor prognosis [41]. Recent studies also show that AR and AKT pathways cross-regulate each other through feedback mechanism and that inhibition of both pathways leads to synergistic reductions of cell proliferation
Vitamin k reduces androgen expression? That goes against much of what ive heard on here