Kuinone - Liquid Vitamin K2 (MK-4)

[Waynish]

@haidut Do you think think will degrade very rapidly if 1 drop is mixed into home made toothpaste composed of coconut oil, baking soda and salt?
Thanks.

EDIT: This home is home made rat toothpaste, of course.

 

[GreekDemiGod]

Has anyone seen digestive benefits from Kuinone orally ingested?

 

[Sitaruîm]

I've been applying a few drops of Kuinone on the right side of my chest for a week or so now and today I noticed a salient difference in the amount of chest hairs on the right compared to what I have on the left side.

Is this a testament of Kuinone's androgenic effects? I'm a 29 yo male. I'll be sure to apply some to the other side to even it out lol.

 

[Runenight201]

Hey is this going to be restocked anytime soon? I found an old bottle that’s almost empty and experienced some great effects from it, but I need to re-up! I don’t want to use Thorne as I like your products here, but I may have no choice my body needs K2!!!

 

[HustlinHussar]

What doses are y'all using, and are the original amounts and potency still the same? Heard on the latest Generative Energy, Danny stated that ~30 drops equated to ~6mg of K2.

Timestamped:

View: https://www.youtube.com/live/JD2TZhGyPkI?si=4-XJSwEGAYp2wTiS&t=2336

 

[Runenight201]

What doses are y'all using, and are the original amounts and potency still the same? Heard on the latest Generative Energy, Danny stated that ~30 drops equated to ~6mg of K2.

Timestamped:

View: https://www.youtube.com/live/JD2TZhGyPkI?si=4-XJSwEGAYp2wTiS&t=2336

The bottle I have is 1.5mg per drop. I would be interested to know what optimal dosages would be. I am currently doing 10K IU Vitamin D with 6mg of K2, but I am definitely just winging it

 

[cremes]

What doses are y'all using, and are the original amounts and potency still the same? Heard on the latest Generative Energy, Danny stated that ~30 drops equated to ~6mg of K2.

Timestamped:

View: https://www.youtube.com/live/JD2TZhGyPkI?si=4-XJSwEGAYp2wTiS&t=2336

He misspoke. If you look at the label on the Kuinone product it specifies that each drop is 2mg. 30 drops will give you 60mg and not 6mg.

I’ve read for a decade plus that the Japanese used massive amounts of K2 and had no I’ll effect. They were treating all sorts of things with 45mg doses, so 60 isn’t outrageous.

 

[Theta]

@haidut​

I started taking AniPrin P a few weeks ago for dental pain. I have never taken aspirin and made sure I took plenty of Kuinone with it.
It immediately handled all dental discomfort I was having.
1/4 teaspoon of AniPrin in water instantly made me feel better. I took about 4 doses so about 1 teaspoon a day. So, 5 grams of aspirin?
After a week or so I was actually feeling EUPHORIC.
A week ago, I had extractions of 7 bottom teeth. The doctor freaked out even though the extractions went smoothly, and I didn't bleed out and, in fact my blood coagulated perfectly and instantly. The euphoria was something glorious. I am usually very anxious about going to the dentist. I was anxiety free and happy to see the dentist. The extractions went smoothy with no anxiety, pain or anything negative.
The doctor ordered me to stop taking the aspirin and he insisted I take Tylenol or Ibuprofen which I don't want to do.
I would like to continue with the aspirin. The euphoria was wonderful. Is the doctor way off base here?
BTW, how many mgs of aspirin in 1/4 teaspoon of AniPrin P?

Georgi, someone told me you said aspirin is actually less likely to cause bleeding at higher doses. Is this true? How do you explain the EUPHORIA with taking the aspirin? Is it safe for me to take 5 grams a day? I am a petite woman. How much of the Kuinone should I take? I was taking 15 drops 4 times a day but cut down to 10 drops twice a day. Also take TocoVit with it.

 

[cremes]

​

The doctor ordered me to stop taking the aspirin and he insisted I take Tylenol or Ibuprofen which I don't want to do.
I would like to continue with the aspirin. The euphoria was wonderful. Is the doctor way off base here?
BTW, how many mgs of aspirin in 1/4 teaspoon of AniPrin P?

Georgi, someone told me you said aspirin is actually less likely to cause bleeding at higher doses. Is this true? How do you explain the EUPHORIA with taking the aspirin? Is it safe for me to take 5 grams a day? I am a petite woman. How much of the Kuinone should I take? I was taking 15 drops 4 times a day but cut down to 10 drops twice a day. Also take TocoVit with it.

No one on this forum is going to give you medical advice. If your doctor recommended this, you are free to follow it or not on your own. But again, no one is going to tell you what to do.

 

[Action]

He misspoke. If you look at the label on the Kuinone product it specifies that each drop is 2mg. 30 drops will give you 60mg and not 6mg.

I’ve read for a decade plus that the Japanese used massive amounts of K2 and had no I’ll effect. They were treating all sorts of things with 45mg doses, so 60 isn’t outrageous.

I don’t think he misspoke. He’s talking about topical application, which provides roughly (according to Ray) 10% absorption. So 10% of 60mg = 6mg.

 

[cremes]

I don’t think he misspoke. He’s talking about topical application, which provides roughly (according to Ray) 10% absorption. So 10% of 60mg = 6mg.

That wasn’t clear from context. Either one of us could be right. The math works either way.

 

[Action]

That wasn’t clear from context. Either one of us could be right. The math works either way.

Danny: "I put it on my... I put about 30 drops, so hopefully... possibly the equivalent to 6mg or so"

Yes, it's pretty clear he's talking about topical application. You wouldn't say "I put it on" if you're talking about ingesting it. Danny's spoken many times about Ray saying you absorb roughly 10% of oil-based vitamins/supplements. If you want to ingest 60mg of Vitamin K do so at your own discretion. But I wouldn't do it cuz you think Danny does it regularly, cuz that's clearly not the case.

 

[HustlinHussar]

Why the preference for topical application when the absorption rate is so low? Is digestive distress that much of a concern

 

[cremes]

Danny: "I put it on my... I put about 30 drops, so hopefully... possibly the equivalent to 6mg or so"

Yes, it's pretty clear he's talking about topical application. You wouldn't say "I put it on" if you're talking about ingesting it. Danny's spoken many times about Ray saying you absorb roughly 10% of oil-based vitamins/supplements. If you want to ingest 60mg of Vitamin K do so at your own discretion. But I wouldn't do it cuz you think Danny does it regularly, cuz that's clearly not the case.

Good ears.

Japan uses 45mg and up, so doubtful there's a problem. I can't find an LD50 for K2 either. Safe!

 

[Mauritio]

Good ears.

Japan uses 45mg and up, so doubtful there's a problem. I can't find an LD50 for K2 either. Safe!

I think its almost weirdly safe for a fat soluble vitamin. Animals studies use the HED of 500-1000mg per day for long periods without saftey issues.

 

[PopSocket]

Kuinone causes some serious stomach issues for me when I take it orally. No idea why so I started using it topically without issues. The current formulation I have is 2mg per drop, how many drops are needed to reach 5mg ? I remember in the past reading that absorption through the skin is very high for k2 but not sure anymore as I see @Action talking about only 10% absorption... @haidut any info on this ?

 

[learnedhelpless]

Kuinone causes some serious stomach issues for me when I take it orally. No idea why so I started using it topically without issues. The current formulation I have is 2mg per drop, how many drops are needed to reach 5mg ? I remember in the past reading that absorption through the skin is very high for k2 but not sure anymore as I see @Action talking about only 10% absorption... @haidut any info on this ?

Yes when dissolved in oils, but ethanol is like 50%+ absorption rate. With SFA added, its like 60-70%. According to Haidut

 

[Inabruzzo]

Hi @haidut , Is there any update on when Kuinone might be available again for purchase? Thanks!

 

[AinmAnseo]

Over the last year a number of people on the forum asked me to release a vitamin K2 supplement as an alternative to the popular (but expensive) Thorne K2 supplement. So, I finally got around to delivering on my promise. Kuinone is a liquid dietary supplement with menatetrenone (MK-4) dissolved in ethanol and SFA esters. If you are wondering what's up with the weird name, well it is a play on the fact that vitamin K is a naphthoquinone, or a type of (q)uinone just like the well-known CoQ10. So, I combined the K from vitamin K and the word quinone to form Kuinone. Hopefully, it is not too confusing to people what the word means.
The fact that it is dissolved in SFA esters + ethanol mixture should dramatically improve topical absorption and allow a much lower daily dose to be used, which will make the bottle last much longer and thus further decrease the overall cost. The product is also available in organic olive oil (EVOOO) as a base/solvent, for people who cannot use ethanol for various personal/religious and/or physiological reasons.
Finally, while the bone benefits of vitamin K2 are known to many people on the forum, some of its "niche" effects are not widely known. So, I compiled a (long) list of references broken down by categories for the people who are interested in finding out more about this amazing substance.

Note: This product contains raw material(s) meant for external use only, in cosmetic or other formulations designed for such external use.

*******************************************************************************
Kuinone is a dietary supplement containing vitamin K2 (MK-4) also known as menatetrenone. This product, while consisting entirely of food-grade ingredients, is sanctioned for external use only.

Servings per container: about 720
Serving size: 1 drop
Each serving contains the following ingredients:

Vitamin K2 (MK-4): 2 mg

Other ingredients: add product to shopping cart to see info
*******************************************************************************

References:

General
Highly recommended dose of MK4 for osteoporosis. - PubMed - NCBI
Vitamins D and K as pleiotropic nutrients: clinical importance to the skeletal and cardiovascular systems and preliminary evidence for synergy. - PubMed - NCBI
Vitamin E and K interactions--a 50-year-old problem. - PubMed - NCBI
Pleiotropic actions of vitamin K: protector of bone health and beyond? - PubMed - NCBI
Exocrine pancreatic secretion of phospholipid, menaquinone-4, and caveolin-1 in vivo. - PubMed - NCBI
Improvement of vitamin K status of breastfeeding infants with maternal supplement of vitamin K2 (MK40). - PubMed - NCBI
Antinociceptive effect induced by intraperitoneal administration of vitamin K2 (menatetrenone) in ICR mice. - PubMed - NCBI
Effect of dietary fat content on oral bioavailability of menatetrenone in humans. - PubMed - NCBI
Effect of food composition on vitamin K absorption in human volunteers. - PubMed - NCBI
Distribution of menaquinone-4, a therapeutic agent for osteoporosis, in bone and other tissues of rats. - PubMed - NCBI


Bone Health
Treatment of glucocorticoid-induced low bone mineral density in children: a systematic review. - PubMed - NCBI
Low-dose menaquinone-4 improves γ-carboxylation of osteocalcin in young males: a non-placebo-controlled dose-response study. - PubMed - NCBI
Vitamin K2 improves femoral bone strength without altering bone mineral density in gastrectomized rats. - PubMed - NCBI
Vitamin K₂ therapy for postmenopausal osteoporosis. - PubMed - NCBI
Vitamin K-dependent carboxylation of osteocalcin affects the efficacy of teriparatide (PTH(1-34)) for skeletal repair. - PubMed - NCBI
Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, do... - PubMed - NCBI
Effects of vitamin K in postmenopausal women: mini review. - PubMed - NCBI
Menatetrenone for the treatment of osteoporosis. - PubMed - NCBI
Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone. - PubMed - NCBI
Amelioration of pregnancy-associated osteoporosis after treatment with vitamin K₂: a report of four patients. - PubMed - NCBI
Clinical results of alendronate monotherapy and combined therapy with menatetrenone (VitK₂) in postmenopausal RA patients. - PubMed - NCBI
Bridging the gap between osteoporosis and osteonecrosis of the jaw: preventing and treating BRONJ with MK4. - PubMed - NCBI
Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral de... - PubMed - NCBI
The prevention of hip fracture with menatetrenone and risedronate plus calcium supplementation in elderly patients with Alzheimer disease: a random... - PubMed - NCBI
Effect of vitamin K2 on cortical and cancellous bone mass and hepatic lipids in rats with combined methionine-choline deficiency. - PubMed - NCBI
Effect of GGCX gene polymorphism on the responses of serum undercarboxylated osteocalcin and bone turnover markers after treatment with vitamin K2 ... - PubMed - NCBI
Effects of long-term vitamin K(1) (phylloquinone) or vitamin K(2) (menaquinone-4) supplementation on body composition and serum parameters in rats. - PubMed - NCBI
Vitamin K₂ alters bone metabolism markers in hemodialysis patients with a low serum parathyroid hormone level. - PubMed - NCBI
Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats. - PubMed - NCBI
Vitamin K2 promotes bone healing in a rat femoral osteotomy model with or without glucocorticoid treatment. - PubMed - NCBI
Effects of combination treatment with alendronate and vitamin K(2) on bone mineral density and strength in ovariectomized mice. - PubMed - NCBI
Prevention of hip fractures by exposure to sunlight and pharmacotherapy in patients with Alzheimer's disease. - PubMed - NCBI
Vitamin K to prevent fractures in older women: systematic review and economic evaluation. - PubMed - NCBI
Vitamin K promotes mineralization, osteoblast-to-osteocyte transition, and an anticatabolic phenotype by {gamma}-carboxylation-dependent and -indep... - PubMed - NCBI
Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three rando... - PubMed - NCBI
Comparison of the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid-treated rats: a bone histomorphometry study. - PubMed - NCBI
Collagen-related abnormalities, reduction in bone quality, and effects of menatetrenone in rats with a congenital ascorbic acid deficiency. - PubMed - NCBI
Prior treatment with vitamin K(2) significantly improves the efficacy of risedronate. - PubMed - NCBI
Short-term menatetrenone therapy increases gamma-carboxylation of osteocalcin with a moderate increase of bone turnover in postmenopausal osteoporo... - PubMed - NCBI
Vitamin K treatment reduces undercarboxylated osteocalcin but does not alter bone turnover, density, or geometry in healthy postmenopausal North Am... - PubMed - NCBI
Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules. - PubMed - NCBI
Vitamin K2, a gamma-carboxylating factor of gla-proteins, normalizes the bone crystal nucleation impaired by Mg-insufficiency. - PubMed - NCBI
[Treatment of primary osteoporosis with vitamin K2]. - PubMed - NCBI
[Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function]. - PubMed - NCBI
Vitamin K2 induces phosphorylation of protein kinase A and expression of novel target genes in osteoblastic cells. - PubMed - NCBI
Vitamin K induces osteoblast differentiation through pregnane X receptor-mediated transcriptional control of the Msx2 gene. - PubMed - NCBI
Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. - PubMed - NCBI
Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis. - PubMed - NCBI
Beneficial effect of pretreatment and treatment continuation with risedronate and vitamin K2 on cancellous bone loss after ovariectomy in rats: a b... - PubMed - NCBI
Infrared analysis of bones in magnesium-deficient rats treated with vitamin K2. - PubMed - NCBI
[Active vitamin D and vitamin K as therapeutic agents for osteoporosis]. - PubMed - NCBI
[Diabetic osteopahty and vitamin K]. - PubMed - NCBI
[Therapeutic approaches for diabetic osteopahty]. - PubMed - NCBI
Vitamin K2 treatment for postmenopausal osteoporosis in Indonesia. - PubMed - NCBI
Geranylgeranylacetone inhibits formation and function of human osteoclasts and prevents bone loss in tail-suspended rats and ovariectomized rats. - PubMed - NCBI
Comparative effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed normal or low calcium diets. - PubMed - NCBI
[The interplay of magnesium and vitamin K2 on bone mineralization]. - PubMed - NCBI
[Vitamin K2 and bone quality]. - PubMed - NCBI
[Vitamin K2 (menatetrenone) and bone quality]. - PubMed - NCBI
Effects of vitamin K2 administration on calcium balance and bone mass in young rats fed normal or low calcium diet. - PubMed - NCBI
Menatetrenone rescues bone loss by improving osteoblast dysfunction in rats immobilized by sciatic neurectomy. - PubMed - NCBI
RETRACTED: Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease. - PubMed - NCBI
Vitamin K2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin (OPG). - PubMed - NCBI
Effects of vitamin K2 (menatetrenone) and alendronate on bone mineral density and bone strength in rats fed a low-magnesium diet. - PubMed - NCBI
Histochemical evaluation for the biological effect of menatetrenone on metaphyseal trabeculae of ovariectomized rats. - PubMed - NCBI
Effects of vitamin K2 in hemodialysis patients with low serum parathyroid hormone levels. - PubMed - NCBI
Vitamin K2 and geranylgeraniol, its side chain component, inhibited osteoclast formation in a different manner. - PubMed - NCBI
Protective effect of vitamins K2 and D3 on prednisolone-induced loss of bone mineral density in the lumbar spine. - PubMed - NCBI
Menatetrenone ameliorates reduction in bone mineral density and bone strength in sciatic neurectomized rats. - PubMed - NCBI
Treatment with vitamin D3 and/or vitamin K2 for postmenopausal osteoporosis. - PubMed - NCBI
Menatetrenone (vitamin K2) acts directly on circulating human osteoclast precursors. - PubMed - NCBI
High serum levels of menatetrenone in male patients with ossification of the posterior longitudinal ligament. - PubMed - NCBI
Effect of menatetrenone (vitamin K2) treatment on bone loss in patients with anorexia nervosa. - PubMed - NCBI
Effect of vitamin K2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats. - PubMed - NCBI
Vitamin K stimulates osteoblastogenesis and inhibits osteoclastogenesis in human bone marrow cell culture. - PubMed - NCBI
Effect of vitamin K2 on cortical and cancellous bones in orchidectomized young rats. - PubMed - NCBI
Pharmacodynamics of menatetrenone and effects on bone metabolism in continuous ambulatory peritoneal dialysis patients. - PubMed - NCBI
Vitamin K2 (menatetrenone) inhibits bone loss induced by prednisolone partly through enhancement of bone formation in rats. - PubMed - NCBI
Menatetrenone prevents osteoblast dysfunction in unilateral sciatic neurectomized rats. - PubMed - NCBI
[Effect of menatetrenone (V.K2) on bone mineral density and bone strength in Ca/Mg deficient rats]. - PubMed - NCBI
Time-dependent effects of vitamin K2 (menatetrenone) on bone metabolism in postmenopausal women. - PubMed - NCBI
Maintenance of trabecular structure and bone volume by vitamin K(2) in mature rats with long-term tail suspension. - PubMed - NCBI
Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency. - PubMed - NCBI
A comparison of alfacalcidol and menatetrenone for the treatment of bone loss in an ovariectomized rat model of osteoporosis. - PubMed - NCBI
Vitamin K2 (menatetrenone) for bone loss in patients with cirrhosis of the liver. - PubMed - NCBI
Effects of phenytoin and/or vitamin K2 (menatetrenone) on bone mineral density in the tibiae of growing rats - PubMed
Effects of vitamin K2 (menatetrenone) on calcium balance in ovariectomized rats - PubMed
Efficacy and safety of Menatetrenone-4 postmenopausal Thai women - PubMed
Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency - PubMed
Effect of menatetrenone on bone mineral density and incidence of vertebral fractures in postmenopausal women with osteoporosis: a comparison with the effect of etidronate - PubMed
Effects of vitamin K on calcium and bone metabolism - PubMed
Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol - PubMed
Effect of combined administration of vitamin D3 and vitamin K2 on bone mineral density of the lumbar spine in postmenopausal women with osteoporosis - PubMed
[Effects of vitamin K2 administration in the patients with severely motor and intellectual disabilities: assessment of bone metabolic marker and bone mineral density] - PubMed
Vitamin K(2) inhibits adipogenesis, osteoclastogenesis, and ODF/RANK ligand expression in murine bone marrow cell cultures - PubMed
Effect of vitamin K2 on three-dimensional trabecular microarchitecture in ovariectomized rats - PubMed
Vitamin K2 (menatetrenone) effectively prevents fractures and sustains lumbar bone mineral density in osteoporosis - PubMed
Short-term effect of vitamin K administration on prednisolone-induced loss of bone mineral density in patients with chronic glomerulonephritis - PubMed
Menatetrenone plus alfacalcidol treatment for bone problems in eight children with skeletal unloading - PubMed
[Vitamin K2 (menatetrenone) treatment increased bone strength in rats given low-calcium diets] - PubMed
Inhibitory effect of vitamin K2 (menatetrenone) on bone resorption in ovariectomized rats: a histomorphometric and dual energy X-ray absorptiometric study - PubMed
Use of vitamin K2 (menatetrenone) and 1,25-dihydroxyvitamin D3 in the prevention of bone loss induced by leuprolide - PubMed
A longitudinal study of the effect of vitamin K2 on bone mineral density in postmenopausal women a comparative study with vitamin D3 and estrogen-progestin therapy - PubMed
[Effects of a vitamin K2 preparation in severely handicapped patients complicated by osteopenia] - PubMed
Menatetrenone ameliorates osteopenia in disuse-affected limbs of vitamin D- and K-deficient stroke patients - PubMed
Vitamin K2 enhances osteocalcin accumulation in the extracellular matrix of human osteoblasts in vitro - PubMed
Vitamin K2 promotes 1alpha,25(OH)2 vitamin D3-induced mineralization in human periosteal osteoblasts - PubMed
The inhibitory effect of vitamin K2 (menatetrenone) on bone resorption may be related to its side chain - PubMed
Effect of vitamin K2 (menatetrenone) on osteoclast-like cell formation in mouse bone marrow cultures - PubMed
[Influence of vitamin D3 on inhibitory effect of vitamin K2 on bone loss in ovariectomized rats] - PubMed
Effects of menatetrenone on the decrease in calcium balance induced by vitamin K-deficient diet and sodium loading in rats - PubMed
Effects of menatetrenone on prednisolone-induced bone loss in rats - PubMed
Effects of menatetrenone on bone loss induced by ovariectomy in rats - PubMed
Vitamin K2 modulates proliferation and function of osteoblastic cells in vitro - PubMed

Inflammation
Vitamin K2 (menatetrenone) inhibits prostaglandin synthesis in cultured human osteoblast-like periosteal cells by inhibiting prostaglandin H synthase activity - PubMed
Menatetrenone inhibits bone resorption partly through inhibition of PGE2 synthesis in vitro - PubMed


Cardiovascular disease (CVD)
Dietary vitamin K and therapeutic warfarin alter the susceptibility to vascular calcification in experimental chronic kidney disease - PubMed
Effects of the blood coagulation vitamin K as an inhibitor of arterial calcification - PubMed
Tissue-specific utilization of menaquinone-4 results in the prevention of arterial calcification in warfarin-treated rats - PubMed
http://www.ncbi.nlm.nih.gov/pubmed/9414028
http://www.ncbi.nlm.nih.gov/pubmed/9247360

Diabetes
http://www.ncbi.nlm.nih.gov/pubmed/21136047
http://www.ncbi.nlm.nih.gov/pubmed/11325029

Kidney Health
http://www.ncbi.nlm.nih.gov/pubmed/22080166

Cancer
http://www.ncbi.nlm.nih.gov/pubmed/23225445
http://www.ncbi.nlm.nih.gov/pubmed/23191943
http://www.ncbi.nlm.nih.gov/pubmed/21661384
http://www.ncbi.nlm.nih.gov/pubmed/21410069
http://www.ncbi.nlm.nih.gov/pubmed/22870131
http://www.ncbi.nlm.nih.gov/pubmed/21163409
http://www.ncbi.nlm.nih.gov/pubmed/21109972
http://www.ncbi.nlm.nih.gov/pubmed/20569983
http://www.ncbi.nlm.nih.gov/pubmed/19639210
http://www.ncbi.nlm.nih.gov/pubmed/19550077
http://www.ncbi.nlm.nih.gov/pubmed/19501932
http://www.ncbi.nlm.nih.gov/pubmed/18251162
http://www.ncbi.nlm.nih.gov/pubmed/17404108
http://www.ncbi.nlm.nih.gov/pubmed/17399847
http://www.ncbi.nlm.nih.gov/pubmed/17376044
http://www.ncbi.nlm.nih.gov/pubmed/16400650
http://www.ncbi.nlm.nih.gov/pubmed/11925874
http://www.ncbi.nlm.nih.gov/pubmed/11807630
http://www.ncbi.nlm.nih.gov/pubmed/10865985
http://www.ncbi.nlm.nih.gov/pubmed/10641439
http://www.ncbi.nlm.nih.gov/pubmed/9827941
http://www.ncbi.nlm.nih.gov/pubmed/9177427
https://www.glowm.com/pdf/Book-OvarianCancerTherapeutics-CC-BY-Ch13.pdf




Neurological Health
http://www.ncbi.nlm.nih.gov/pubmed/24108469
http://www.ncbi.nlm.nih.gov/pubmed/23682563
http://www.ncbi.nlm.nih.gov/pubmed/20092997
http://www.ncbi.nlm.nih.gov/pubmed/19235890
http://www.ncbi.nlm.nih.gov/pubmed/14704312

Testosterone
http://www.ncbi.nlm.nih.gov/pubmed/21914161
http://www.ncbi.nlm.nih.gov/pubmed/21894328

Estrogen
http://www.ncbi.nlm.nih.gov/pubmed/15763078

The dosages for MK-4 products that I see are usually for around 500 mcg.
I see that one drop of this is 2 mg.
Are most dosages out there too low?
Paul

 

[AinmAnseo]

My experience it messed with my sleep if I used it before bed.

Did you start to take it just in the morning? Did that work better? Paul