The dosage for humans was not high at all - 483mg alpha tocopherol. The dosage for rodents was a bit higher - converted into human dosage it would be about 1,200mg - 1,500mg per day.
Vitamin E raised testosterone in rodents by about 60% in plasma and 53% in tissue (testis), and in humans it raises total testosterone by 30% and free testosterone by about 27%.
https://www.jstage.jst.go.jp/article/en ... 3_287/_pdf
"...It is known that the administration of vitamin E activates spermatogenesis (Ichihara, 1967). It has also been demonstrated by electronmicroscopy that vitamin E activates the development of smooth surfaced ER in Leydig cells, suggesting the enhancement of steroidogenesis (Umeda, 1978). In the present study, we observed a significant elevation of testosterone levels in both the rat testicular tissue and plasma after long-term vitamin E administration. In addition, it was also revealed that in human subjects testosterone production was activated by vitamin E administration. Thus, vitamin E may play an important role in the biosynthesis of pituitary gonadotropins and testicular testosterone."
Vitamin E raised testosterone in rodents by about 60% in plasma and 53% in tissue (testis), and in humans it raises total testosterone by 30% and free testosterone by about 27%.
https://www.jstage.jst.go.jp/article/en ... 3_287/_pdf
"...It is known that the administration of vitamin E activates spermatogenesis (Ichihara, 1967). It has also been demonstrated by electronmicroscopy that vitamin E activates the development of smooth surfaced ER in Leydig cells, suggesting the enhancement of steroidogenesis (Umeda, 1978). In the present study, we observed a significant elevation of testosterone levels in both the rat testicular tissue and plasma after long-term vitamin E administration. In addition, it was also revealed that in human subjects testosterone production was activated by vitamin E administration. Thus, vitamin E may play an important role in the biosynthesis of pituitary gonadotropins and testicular testosterone."