About a year ago I started experiencing terrible symptoms of worsening inflammation. My joints were painful, my cognition and physical coordination began to decline. Finally my eyes became very bloodshot(scary!). I din't know what was wrong and thought I might be having a relapse of a mild case of chikungunya that I had experienced earlier. By chance, I looked closely at my bottle of vitamin d and noticed it was 10,000mg! I know! It was crazy that I didn't notice it before but there it was. I was taking one daily, very faithfully for probably 4 or 5 months. I immediately began to research the signs of vitamin d toxicity and my symptoms matched. Of course, I stopped taking it immediately and the symptoms began to diminish and finally disappeared. After a few weeks I took a 1000mg dose just to check and the joint pain came back that day! Knowing that it's stored in the body, I've been hesitant to take anymore for now. I may retest taking 1000mg at a later time.
I have been applying Ray Peat's advice for about 6 years now. Included in my supplementation regime was taking 1000mg of Vitamin D3 daily, along with my vitamin e, aspirin and k.
I just wanted to share my experience as an anecdote, but I found some info that seems to back my experiences:
How A Vitamin D Test Misdiagnosed African-Americans
Here's a section from the article:
The 25-hydroxy form is tightly bound to a protein, and as a result, bone cells, immune cells and other tissues that need vitamin D can't take it up. It has to be converted by the kidneys into a form called 1,25-dihydroxyvitamin D.
For Caucasians, blood levels of 25-hydroxyvitamin D are a pretty good proxy for how much of the bioavailable vitamin they have. But not for blacks.
HEALTH
Medical Panel: Don't Go Overboard On Vitamin D
That's because blacks have only a quarter to a third as much of the binding protein, Thadhani says. So the blood test for the 25-hydroxy form is misleading. His study finds that because of those lower levels of the protein, blacks still have enough of the bioavailable vitamin, which explains why their bones look strong even though the usual blood tests say they shouldn't.
"The conclusion from this study is that just because your total levels are low, it doesn't mean we need to replace vitamin D" using supplements, Thadhani says. The study was published Wednesday in the New England Journal of Medicine.
i meant iu"s not mg, sorry
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