Vitamin B1 (Thiamine) Deficiency: The "Great Imitator" Of Other Illnesses

[Peater]

Great vid @Simatta thanks

 

[yerrag]

Agreed. You might like this video as well. Great point on potassium and I think magnesium as well as the obvious B complex.



I created Time-Stamps took like 2 hours but I felt it worthwhile.

00:39 - Why Elliot got interested in thiamine (author Dr. Derrick Lonsdale and the myth that thiamine deficiency disappeared)

02:00 - Thiamine deficiency first presented in Japan when refining rice to white rice because it was more aesthetically pleasing, which became a status symbol. Symptoms such as Beri Beri, peripheral nervous system disorder, Wernicke-korsakoff syndrome, psychosis, cardiac arrhythmias, gastrointestinal system via constipation, GERD, breathlessness, inability to concentrate, regulate emotions.

04:00 - When you refine foods you run into vitamin deficiencies even if physicians state thiamine deficiency is a thing of the past, Elliot has found this not to be the case. 04:43 - Alcoholic’s, anorexia begins to reseed usually on a lot of carbs and needs thiamine significantly.

05:16 - Early stage of thiamine deficiency doesn’t necessarily present as typical symptoms

05:27 - Dr. Derrick Lonsdale was a Cleveland Clinic Pediatrician who wrote a book co-authored with Chandler Marrs Thiamine Deficiency Disease, Dysautonomia, and High-Calorie Malnutrition

06:11 - Thiamine deficiency isn’t a thing of the past, Elliot’s perspective on going back to basics on to why we need thiamine. When you eat certain foods like fats, carbs, and proteins. We need enzymes, so say you consume sugar, and it is transported into the cells, the end product is usable energy called ATP. The cells need this to do things. For the cells to work you need co-factors like vitamins/minerals. Thiamine is a very important part of those enzymes to make utilization of energy from these foods particularly carbohydrates.

08:15 - Problem with refining the foods you take out the nutrients and minerals. So you get a pure energy food substrate, but without the co-factors to make use of this without taxing your reserves.

08:52 - Sugar cane has a vast amount of vitamins and minerals. And with thiamine being water-soluble you need to get them from somewhere, so you need a constant supply of them.

09:19 - Every time you have sugar or fats, you are using some of the thiamine you have. And ordinarily, when eating whole foods, you’ll be adding in thiamine when consuming sugar. The problem lies when you’re using refined foods you’re taxing thiamine. Therefore the problem you run into is carb metabolism issues cause the necessary co-factors aren’t any longer present with high-calorie vitamin/mineral deficits.

10:37 - Acetylcholine is one of the major neurotransmitters and needs thiamine to keep healthy levels. Because it helps with the synthesis of neurotransmitters. Thus nerve transmission and thinking requires thiamine.

10:52 - One of the symptoms of cognitive decline is from deficits of thiamine.

11:04 - Research suggests that thiamine is important for maintaining the health of the myelin sheath and the neurons themself.

11:21 - There is a part of the brain called the limbic system and it's part of the brain stem, (emotional brain) it is a primitive part that has a lot of control of the autonomic nervous system.

11:38 - The cells in that part of the brain are particularly sensitive to thiamine deficiency. And when there is no longer thiamine in that part of the brain it acts similar to a deficiency of oxygen. And we know what happens when there is a deficit of oxygen. The cells die and they no longer function. So this is similar to what happens to that part of the brain when thiamine is low.

12:03 - People can get more emotional, mood problems. Some symptoms of early stages of thiamine deficiency are depression, emotional instability, mood changes, bipolar, schizophrenia. And even though it impacts our emotions, it can impact our entire body. Because our nervous system is really in control of the vasculature, so it can control how many of the organs function especially the cardiovascular system. So when you look at early-stage thiamine deficiency, it can manifest in multiple different ways. One of the first symptoms is heart palpitations, but eventually, the heart can enlarge to try to make up what it perceives to be an oxygen deficit. Which can lead to heart failure.

13:12 - Even benign symptoms like Reynaurds which is the uncontrolled constriction and dilation of the blood vessels in response to different temperatures. But essentially when there is a thiamine deficiency, it means the nervous system can effectively no longer adapt to the environment. So temp regulation can be skewed.

13:36 - There is a condition called POTS postural orthostatic tachycardia syndrome, this typically involves the nervous system being unable to control the blood vessels which can result in all types of symptoms.

13:50 - This can also impact the gut, because we have to understand that the gut, in order for it to propel food from the stomach down the intestine it requires it to contract. So one of the aspects you’ll find is SIBO small intestinal bacterial overgrowth due to improper migrating motor complex which can go unrecognized.

14:15 - Pins and needles around the arms or neurological symptoms like this can be due to thiamine deficiency

14:52 - Thiamine’s function in energy metabolism. Energy metabolism occurs in every single cell. In order for all cells to do what they need to do they need enough energy. And when you look at various diseases all have mitochondrial dysfunction or defective energy production. This refers to cells no longer being able to make energy as well as it once did. And when we look at thiamine, it sits at the top of how a cell can make energy. Without it, energy production is mostly halted.

15:54 - What Derrick Lonsdale found was that people whom he treated, had skewed immune function and that’s because the immune system requires energy. So he saw in many of his client's poor immune function due to thiamine deficits.

16:16 - The integrity of tissue, say the bladder, the cells that line in the bladder being mucosa and in order for that mucosa to be healthy you need enough energy to produce healthy tissue. This being a more novel idea to medicine that restoring energy production restores tissue health. And how thiamine can improve so many conditions even that seem unrelated.

17:33 - A lot of research on thiamine being used for things like Chronic Fatigue. Which its base being mitochondrial dysfunction. Fibromyalgia being another. And the onset of CF and FB showed its face typically with the use of an antibiotic classified as a fluoroquinolone antibiotic. One of the aspects of this is fluoroquinolone depletes thiamine, and so researchers are using thiamine to successfully treat CF and Fibromyalgia. In one small study on Fibromyalgia, they found up to 80% of 3 people just supplementing thiamine in relief of malaise, subjective feeling of well-being, etc.

18:52 - Fluoroquinolone depletes thiamine in unknown ways but it has been documented. Elliot suspects oxalate components but it is very complex. And it may inhibit the absorption of thiamine. Ruptured tendons being an issue with fluoroquinolone, which likely has an issue with glycine, vitamin B6, vitamin C. It gets progressively complex.

20:45 - Trickle-down effect or downstream effect that can affect the metabolism of various B vitamins and collagen synthesis and energy metabolism. Some aspects being disruption of microbiome and oxalates.

21:09 - Need b vitamins to get nutrients in our tendons.

21:25 - Other medications such as oral contraceptives, metformin, (possibly NSAIDs), and many others reduce thiamine in the body.

22:09 - Most B vitamins are produced by the microbiome. But the majority comes from the diet.

22:31 - Another problem is absorption. One issue is tannins in tea, coffee, sulfites, hydrogen sulfite (imbalanced gut bacteria that produces hydrogen sulfite can degrade B vitamin in the gut so it doesn’t even get absorbed). Another issue is celiac, Crohn’s disease can potentially inhibit the absorption of thiamine. Also, genetic transporter issues such as mutations in genes would prevent proper absorption of thiamine more easily.

24:04 - Doses of thiamine. The type of thiamine named Thiamine HCL is of low bio-availability. When prescribed at therapeutic doses, not much is absorbed. But mega doses of around 300-600mg a day could have beneficial effects. Thiamine transporters on the cell membrane that help thiamine get into the cell. And this makes testing thiamine difficult. Because someone could have normal blood levels of thiamine, but it doesn’t mean it can get into the cell, and on top of that it doesn’t mean it can be utilized once in the cell. So to find thiamine that can get into the cell Benfotiamine can be used to readily get into the cell and treat diabetic neuropathy.

26:12 - Certain types of thiamine can get into the brain. TTFD Thiamine is a Lipo-Soluble that can get into the brain as shown in Japanese studies. These are lower doses, such as below 100mg, although higher doses could prove very helpful.

27:23 - When there is a chronic deficiency like thiamine. Because we have various machinery in our cells that use thiamine, and when we have low levels of the vitamin, the machinery [proteins, enzymes] are naturally going to be down-regulated to match the deficit. In that case, the enzymes may be down-regulated, but likewise, the transporters may also be down-regulated. So if there aren’t enough enzymes or transporters for thiamine, it won’t be used to a high efficacy. They basically found that you may need to do high dose thiamine to send a message to the body to encourage the body to adapt its machinery to match the requirement [proteins, enzymes, transporters] to heal the energy metabolism. Even POTs situations might need 3-5 months of treatment to see the benefit in those situations.

30:10 - POTs many symptoms can be eradicated permanently with thiamine if structural damage hadn’t occurred. Digestive symptoms, blood pressure issues, etc. Can be resolved with treatment.

31:17 - A chronic deficiency can go on for a very long time. And oftentimes you need a stressor to initiate warning signs of that chronic deficiency. It could be a vaccine, infection, UV light, life event, etc. Which can put a lot of stress on the system, which can illustrate the thiamine deficiency.

32:37 - Gardasil vaccine leads to POT’s in many situations and thiamine can treat this.

33:12 - Type 1 and Type 2 diabetics have shown 50-60% less thiamine in these groups in studies. What we see in the cell for these individuals impacts drastically how insulin works in these individuals. Even in non-diabetes thiamine deficits can show hypo or hyperglycemia. So blood sugar balance is very dependent on thiamine. And even in different eating behaviors like bulimia and anorexia, it can cause a voracious appetite or disenchantment with food, and with thiamine, you can treat both of these conditions. 34:35 - Thiamine is a very safe treatment. Upon administrating thiamine, we need magnesium. Sometimes when you administer thiamine you might see heart palpitations initially, if you take it with magnesium with a b complex these didn’t occur.

36:16 - Learning difficulties, autism seem to improve significantly with thiamine. As well as chronic vomiting, gastrointestinal issues, nausea, migraines, headaches all got better with thiamine administration. As well as cardiovascular issues typically respond favorably.

37:17 - Much of the heart's electrical activity is coordinated by the autonomic nervous system through the vagus nerve. And when there is low thiamine, it can really breakdown the body’s ability to regulate the stress system. One of the big symptoms is an over-active sympathetic nervous system [fight or flight]. Thiamine can really help intervene with these issues.

38:37 - Why do you think thiamine doesn’t get much attention? Elliot finds it odd there isn’t much publicity surrounding this substance. It is such a lone-wolf and so he hopes the book can encourage further research surrounding this safe effective treatment of so many conditions. Especially for those using sugar and refined foods as calorie sources.

39:45 - People with kidney failure, gastric bypass, anyone with anorexia, the elderly, and anyone who is young such as children all are very susceptible to thiamine deficits. The general population at large is likely suffering from some sub-clinical thiamine deficiency. As well with many people taking over-the-counter drugs, it can lead to deficits in thiamine. And especially gut dysbiosis (constipation or diarrhea). Mold toxicity is another major aspect that can deplete thiamine. He finds most people eating refined carbs especially are at risk of thiamine deficiency. And if you drink tea or coffee do so away from foods if you refuse to supplement. If you boil potatoes you lose the B vitamin.

Appreciate your making the time-stamps. Helped a lot. I ended up watching the video as well.

 

[Peater]

Without knowing how much coffee effects thiamine sufficiency (or its action), it's hard to know how it fits into a healthy diet.

 

[Perry Staltic]

Without knowing how much coffee effects thiamine sufficiency (or its action), it's hard to know how it fits into a healthy diet.

For me it doesn't fit because I can't control how much I consume. Yet I still drink coffee, I just don't swallow, but spit it out into another cup like chewing tobacco. Problem solved. Get the taste I love with a slight head buzz without the whole-body weirdness I used to feel. Doing it that way I can make it ultra, ultra strong, which actually makes about 1 cup per day sufficient.

 

[Peater]

For me it doesn't fit because I can't control how much I consume. Yet I still drink coffee, I just don't swallow, but spit it out into another cup like chewing tobacco. Problem solved. Get the taste I love with a slight head buzz without the whole-body weirdness I used to feel. Doing it that way I can make it ultra, ultra strong, which actually makes about 1 cup per day sufficient.

Like cigar smoking too, you don't inhale

 

[Simatta]

Appreciate your making the time-stamps. Helped a lot. I ended up watching the video as well.

You're welcome. Glad you watched and enjoyed!

 

[Simatta]

Another batch of time-stamps regarding thiamine and the relationship with keto and carnivore diets. Made a detailed set of time-stamps as well to save people some time.



00:10 - Summary of examining what sort of symptoms someone experiencing thiamine deficiency. What are some of the causes of why people develop this deficit? And if carnivore or keto diets are sufficient for addressing this deficiency? As well as some case-studies regarding people on keto or carnivore diets that they didn’t see results on that diet until supplying thiamine at high doses.

01:01 - The many signs of thiamine deficiency are GERD [gastrointestinal esophageal reflux disease], bloating, constipation, delayed gastric emptying, gastroparesis, visceral hypersensitivity, undigested food in stools due to lack of pancreatic enzymes from low stomach acid, gut pain, dizziness, POTS [postural orthostatic tachycardia syndrome] & visual disturbances, low/unsteady blood pressure, tachycardia, central fatigue or systemic fatigue, fibromyalgia, chronic fatigue syndrome, carbohydrate/alcohol intolerance, neuropathy/pain tingling, poor temperature regulation, insomnia, low/high appetite, inability to gain weight, Raynaud's/poor circulation, EMF/light sensitivity, brain-fog/anxiety, breathlessness or air hunger, sleep apnea, etc.)

03:44 - The real pioneer of this therapy is Dr. Derrick Lonsdale, part in due to research done in Japan. He found benefits by pioneering research in the Cleveland Clinic to treat autonomic nervous system dysfunction, autism, ADHD, behavioral & neuropsychiatric disorders, chronic fatigue syndrome, post-viral fatigue syndrome, etc. All with Thiamine.

04:32 - What you really need to know is that the more glucose you need to process the more thiamine you will need. Because thiamine is absolutely critical for glucose metabolism and fatty acid metabolism. This is through glycolysis generating as a co-factor for the enzyme called pyruvate dehydrogenase. It is also a co-factor in a process called the Kreb cycle, which is the next stage in how we are deriving energy from various food components. Thiamine is necessary for glucose and fats, and proteins for energy as well.

05:15 - Some of the other main functions is that it’s a co-factor for many other enzymes such as for Anabolic Reactions such as the Pentose Phosphate Pathway used to regenerate glutathione to protect against oxidative stress, and also how we synthesizing macromolecules such as fatty acids to make myelin sheath (antioxidant system, nucleic acid synthesis, fatty acid synthesis). Furthermore, thiamine is central in how we are breaking down certain amino acids particularly from red meat sources or sources that contain leucine, valine, and isoleucine, so how we are breaking these down is relying upon a thiamine dependent enzyme, this falls under Branched Chain Amino Acids (energy metabolism, cholesterol synthesis, neurotransmitter synthesis). Likewise, how we are taking certain odd chain fats and running them through a separate phase of breakdown called Alpha Oxidation is a fairly new established function of Thiamine known as Odd Chain Fatty Acids ( Acetyl-CoA, etc. Energy Metabolism).

06:30 - Aside from its role in processing macro-nutrients, it's also central in the nervous system. In fact, a thiamine deficiency primarily affects the nervous system or affects the nervous system first of all. It is needed to synthesize the neurotransmitter acetylcholine and also glutamate and the inhibitory neurotransmitter GABA. Furthermore, neurons utilize thiamine in how well they are able to regulate the various ions across the plasma membrane. And then we are using it to maintain and build myelin sheath. And actually, one of the forms of thiamine is necessary or seems to be necessary for how we are conducting nerve signals transferring information from one neuron to another neuron.

07:21 - There are certain areas of the brain which are particularly sensitive to thiamine deficiency, and this is because they have a very high-rate of oxygen utilization and energy metabolism. And these are the lower portions of the brain referred to as the brain stem, mamillary body, cerebellum, hypothalamus, thalamus, etc. Interestingly these parts of the brain are primarily in control of the autonomic nervous system, which is divided up into two main branches. The sympathetic [fight or flight] and parasympathetic [rest & digest] nervous system. And what this is essentially doing is it allowing us to adapt to environmental changes or environmental stimuli via controlling those involuntary processes that we don’t need to think about [body temperature, digestion, heart-rate, constriction and dilation of our blood vessels, etc.] and when we are thiamine deficient, these areas of the brain and this area of our autonomic nervous system are most affected. And we can end up with dysfunction in this area of the brain which creates dysfunction in the entire nervous system, as we begin to fail to adapt to environments appropriately. Essentially losing anti-fragility in the process due to having all types of misfiring by being thiamine deficient.

08:52 - Lonsdale characterized high-calorie malnutrition. This comes down to an up-regulation of macronutrients (refined fats, refined carbs, reined proteins) and down-regulation of micronutrients (vitamins, minerals, other nutrients). And as we consume too many refined macronutrients we deplete ourselves of micronutrients which leads to many of these disorders listed above. This excessive intake of glucose without adequate levels of co-factors that thiamine and other vitamins and minerals provide lead to sub-clinical deficits that leads to all sorts of a constellation of symptoms as illustrated throughout this video. Thiamine is particularly necessary for the appropriate metabolism of carbohydrates in particular, so those diets higher in carbs especially refined ones as you see with Dr. Ray Peat will require the higher need for thiamine and its cofactors, B-complex, magnesium, and potassium.

11:06 - Based on this concept previously spoken about here. The autonomic nervous system is in control of things like blood pressure, gut motility, body temperature, constriction and dilation of blood vessels, and those parts of the brain are also in control of appetite, and nutrient partitioning. As we can see many of the symptoms can be linked back to problems with the autonomic nervous system which is linked to thiamine deficits.

11:42 - Some primary risks are heavy alcohol use, whether binge or chronic use. High sugar consumption, white rice, refined carbs (bread, grains, etc.). Chronic digestive issues IBS-C or D, or A, diarrhea, constipation, etc. High activity stressors: athletics, workload, family breakup, or trauma. They tend to be Doers, so go-get-'em attitudes tend to lead to a crash due to thiamine depletion, this is partly due to ramping up the metabolism which requires a greater need for micronutrients like thiamine and its co-factors. Pharmaceutical Rx like diuretics or antibiotics (metronidazole) also induce deficits in thiamine which cause thiamine-wasting. Surgery/viral or bacterial infections low-grade or otherwise.

14:30 - After crashing from one of the above, generally you will see further carbohydrate metabolism and alcohol metabolism intolerances. Nervous system collapse, on fire, or chronic fatigue. A negative response to B vitamins & sometimes magnesium. Slight improvement on keto/carnivore diets but about 50% or so, this is because there is less requirement for thiamine on these diets. However, this doesn’t mean to stay on these diets as it doesn’t address the deficit but buys time. Neurological cardiovascular and/or digestive symptoms. Insomnia or not feeling rested after sleep. These all can drastically impact overall well-being and make it difficult to discover how to recover from this deep thiamine deficit.

17:10 - It is important to note that in opposition to the conventional way of viewing disease. Elliot Overton likes to look at it as a Spectrum of Severity. A conventional medical physician sees it as falling in the box of health or disease. But there is a large grey area in-between. Someone could be moderately healthy, but still, have moderate insufficiency, and they could develop a deficit of thiamine or other micronutrients as they gradually develop this deficit. But because they do not fit the diagnostic of a full-blown disease medicine dismisses them because they don’t fit diagnostic criteria. Which makes people ignore subtle sub-clinical deficits for long periods of time which can wreak havoc or lead to the straw the breaks the camel's back as it were.

18:15 - The Crash or Trigger is usually the straw that broke the Camel’s back. Metabolic stressors (trigger) are often from a chronic insufficiency minor or few symptoms and on the timeline, a Crash & Metabolic Shift can occur with multiple symptoms manifesting due to enzymatic down-regulation. It could be a loss of a loved one, car accident, surgery, excess food shifts, loss of a job, etc. So this acute event usually sends someone over the edge which shifts someone’s metabolism as they begin to develop symptoms they never had before, which seemingly randomly comes out of nowhere. And in the literature, it shows that actually people who are deficient in certain nutrients like thiamine, then the enzymes that use this nutrient you’ll see down-regulated which creates this enzymatic down-regulation which has to do with a sudden onset of symptoms out of nowhere that relied upon those enzymatic processes.

19:46 - So if we look at the full-blown deficiency of thiamine you find Berberi & Wernicke’s Encephalopathy. Which usually requires 100-1,000mg of thiamine per day independent of a healthy diet. Therapy may be necessary for 6-12 months to achieve full-blown remission of this disease. And carnivore and keto diets may simply reduce symptoms but ultimately you want to restore carbohydrate metabolism. And this is more evidence that diet alone is simply not enough. The RDA for thiamine is currently only about 1-1.5mg a day.

21:33 - Case Study 1. Male mid-twenties with a Medical history of {Neuropathy, Severe Constipation (once every 2-3 weeks), GERD & constant bloating, Severely underweight 116 pounds [53kg] at 6 feet tall and inability to gain weight, Unexplained low blood pressure, Autoimmune issues, Extreme fatigue, dizziness, breathlessness, and low blood pressure}. This client has had a very high and long consumption of white rice as a staple in his diet. And he has his Trigger being hospitalized 10 years prior. He tried multiple diets, even a strict PKD Carnivore diet for around 6 months, which helped with autoimmunity but not most of the other symptoms. He saw Elliot’s videos and got in contact with him. As he looked at it, he had this individual take TTFD (bioavailable thiamine titrating up to 150mg a day), high dose B complex, vitamin C, and magnesium malate.

24:28 - After an 8-week follow-up after one day, daily bowel movements. GERD, bloating, and indigestion almost disappeared after a few weeks. Gained 17.63 pounds (8kg) for the first time in nearly 10 years. Enjoys working out and is building muscle rapidly. Fatigue improved greatly, with no daytime sleeplessness. Overall immune symptomatic improvement in a short time frame. This all changed with just the suggestions of TTFD Thiamine with the co-factors listed above. Just another example of how some simple changes can drastically alter someone’s life.

25:39 - Case Study 2 Male mid-twenties with a Medical History of {Severe fatigue, and mental sluggishness, depression (feeling dissociated from the body), Chronically cold, and poor circulation, Chronic burping, and bloating, poor gastric motility (explaining that it felt like a rock was in his stomach) & constipation/loose stools, Terrible recovery from exercise, Previous neuropathy, palpitations (cardio abnormalities) and twitching.

27:07 - History continued: Long consumption of white rice/bodybuilder diet & alcohol during university. Antibiotics & infection trigger. Lost tolerance to carbs, coffee, and alcohol. Multiple variations of keto/carnivore for 18 months with some improvement, but still struggling.

27:54 - Lab work CBC + CMP Unremarkable. Organic acids (after a few weeks of B1 therapy). A slight elevation in lactate (related to low thiamine), 2-hydroxyisovaleric acid (BCKDH marker) [marker related to branch-chain amino acid metabolism]. Minor elevations in oxalate markers.

28:27 - Glycolytic Cycle Metabolites Lactic acid 22 High (acceptable reference range 0.74-19.0). Amino Acid Metabolites 2-hydroxyisovaleric acid 3.1 (acceptable reference range 0.41 or lower). Oxalate Metabolites Glycolic Acid 111 High (acceptable reference range 18-81).

28:42 - Therapy Worked up to 500mg TTFD Thiamine w/ Magnesium malate (he got worse initially, then got better, as this fluctuates due to increasing metabolic machinery to adapt to thiamine levels rising so titrate gently). With every subsequent increase in the dose, his symptoms got worse initially then better. Body heat increased like a furnace. Periods of feeling euphoric, better concentration, and energy. Bloating, burping, and digestive system made major improvements. Sometimes it can take 6-8 months to recover the machinery necessary to restore health from chronic thiamine deficiency.

30:02 - Case Study 3 Male early-twenties with a Medical History: Trigger - early stress at 10 years old, and he binged eat sugar as a coping mechanism leading to a bout of severe constipation. Gradually he developed the following symptoms. Burning mouth, feet, neuropathy. Severe SIBO, GERD, bloating, and slow motility + laryngopharyngeal reflux. Severe fatigue, poor temperature regulation, and no libido. Excessive salivation in the mouth, dizziness, and balance problems. Chronic pain, visual disturbances, etc.

32:00 - History continued. Tried almost every diet. Got worse with carnivore/keto & restrictive diets. Learned of thiamine deficiency, took benfotiamine before the consultation. Benfotiamine improved dizziness, and balance almost immediately. Saw Elliot’s videos and got in contact. Elliot doesn’t generally use benfotiamine versions, but the client noticed a difference with it at just one capsule a day.

32:44 - Therapy: Increase benfotiamine to 250mg 4 times a day. B complex, riboflavin & magnesium, etc. A gradual shift from benfotiamine to TTFD version of thiamine.

33:33 - Results after a few weeks. An increase in benfotiamine caused temporary improvement then worsening in symptoms. Shift to TTFD 300mg a day. Now able to say many different foods - meats, veggies, etc. within about two weeks on TTFD version of thiamine. Also able to exercise. Reflux completely disappeared, bloating/burping 70% improvement. Upper GI motility restored - bowel movement twice per day. Libido returned. Fatigue, LPR, and salivation still present. Early days. [My added suspicion might be sulfur metabolism issues with the benfotiamine version?].

34:21 - Case Study 4. Female mid-60’s with a Medical History: Air hunger and breathlessness with fatigue. Unexplained low blood pressure and high pulse rate. Central sleep apnea, and dizziness. History of metformin use (thiamine depletion). Elliot speaks to this case to illustrate how one single deficiency can manifest as several different symptoms.

35:53 - Therapy before coming to see Elliot: Self-prescribed 900mg benfotiamine and 600mg sulbutiamine, B complex and minerals, carnivore diet. She noticed little change in fatigue but a big improvement with air hunger and breathlessness. And her pulse rate balanced and her blood pressure balanced fast. When she doesn’t take that dose these symptoms return.

36:53 - Central sleep apnea is another one of those unknown symptoms of a thiamine deficit, related to oxygen deficiency in the brain.

37:04 - Thiamine Deficiency Disease, Dysautonomia, and High-Calorie Malnutrition by Derrick Lonsdale and Chandler Marrs. How to address this issue in more depth get this book!

37:48 - Next videos Clinical laboratory indications of thiamine deficiency. Are there lab tests available? Which labs might indicate a deficiency? Which is the best form of thiamine to take? What is the difference between the forms of thiamine? Which health conditions might benefit from which form?

 

[Simatta]

Great vid @Simatta thanks

You're welcome ^_^.

 

[PhilParma]

I find clients with sulfur issues can sometimes experience very wonky symptoms from benfo- and allithiamine versions. Particularly difficulty breathing, tightness in chest, weird soreness in muscles.

I experienced this. Shoulder pain, arm pain, quite unpleasant. Also hair fall. Anything sulfuric seems to make my hair fall.

 

[Perry Staltic]

Another batch of time-stamps regarding thiamine and the relationship with keto and carnivore diets. Made a detailed set of time-stamps as well to save people some time.



00:10 - Summary of examining what sort of symptoms someone experiencing thiamine deficiency. What are some of the causes of why people develop this deficit? And if carnivore or keto diets are sufficient for addressing this deficiency? As well as some case-studies regarding people on keto or carnivore diets that they didn’t see results on that diet until supplying thiamine at high doses.

01:01 - The many signs of thiamine deficiency are GERD [gastrointestinal esophageal reflux disease], bloating, constipation, delayed gastric emptying, gastroparesis, visceral hypersensitivity, undigested food in stools due to lack of pancreatic enzymes from low stomach acid, gut pain, dizziness, POTS [postural orthostatic tachycardia syndrome] & visual disturbances, low/unsteady blood pressure, tachycardia, central fatigue or systemic fatigue, fibromyalgia, chronic fatigue syndrome, carbohydrate/alcohol intolerance, neuropathy/pain tingling, poor temperature regulation, insomnia, low/high appetite, inability to gain weight, Raynaud's/poor circulation, EMF/light sensitivity, brain-fog/anxiety, breathlessness or air hunger, sleep apnea, etc.)

03:44 - The real pioneer of this therapy is Dr. Derrick Lonsdale, part in due to research done in Japan. He found benefits by pioneering research in the Cleveland Clinic to treat autonomic nervous system dysfunction, autism, ADHD, behavioral & neuropsychiatric disorders, chronic fatigue syndrome, post-viral fatigue syndrome, etc. All with Thiamine.

04:32 - What you really need to know is that the more glucose you need to process the more thiamine you will need. Because thiamine is absolutely critical for glucose metabolism and fatty acid metabolism. This is through glycolysis generating as a co-factor for the enzyme called pyruvate dehydrogenase. It is also a co-factor in a process called the Kreb cycle, which is the next stage in how we are deriving energy from various food components. Thiamine is necessary for glucose and fats, and proteins for energy as well.

05:15 - Some of the other main functions is that it’s a co-factor for many other enzymes such as for Anabolic Reactions such as the Pentose Phosphate Pathway used to regenerate glutathione to protect against oxidative stress, and also how we synthesizing macromolecules such as fatty acids to make myelin sheath (antioxidant system, nucleic acid synthesis, fatty acid synthesis). Furthermore, thiamine is central in how we are breaking down certain amino acids particularly from red meat sources or sources that contain leucine, valine, and isoleucine, so how we are breaking these down is relying upon a thiamine dependent enzyme, this falls under Branched Chain Amino Acids (energy metabolism, cholesterol synthesis, neurotransmitter synthesis). Likewise, how we are taking certain odd chain fats and running them through a separate phase of breakdown called Alpha Oxidation is a fairly new established function of Thiamine known as Odd Chain Fatty Acids ( Acetyl-CoA, etc. Energy Metabolism).

06:30 - Aside from its role in processing macro-nutrients, it's also central in the nervous system. In fact, a thiamine deficiency primarily affects the nervous system or affects the nervous system first of all. It is needed to synthesize the neurotransmitter acetylcholine and also glutamate and the inhibitory neurotransmitter GABA. Furthermore, neurons utilize thiamine in how well they are able to regulate the various ions across the plasma membrane. And then we are using it to maintain and build myelin sheath. And actually, one of the forms of thiamine is necessary or seems to be necessary for how we are conducting nerve signals transferring information from one neuron to another neuron.

07:21 - There are certain areas of the brain which are particularly sensitive to thiamine deficiency, and this is because they have a very high-rate of oxygen utilization and energy metabolism. And these are the lower portions of the brain referred to as the brain stem, mamillary body, cerebellum, hypothalamus, thalamus, etc. Interestingly these parts of the brain are primarily in control of the autonomic nervous system, which is divided up into two main branches. The sympathetic [fight or flight] and parasympathetic [rest & digest] nervous system. And what this is essentially doing is it allowing us to adapt to environmental changes or environmental stimuli via controlling those involuntary processes that we don’t need to think about [body temperature, digestion, heart-rate, constriction and dilation of our blood vessels, etc.] and when we are thiamine deficient, these areas of the brain and this area of our autonomic nervous system are most affected. And we can end up with dysfunction in this area of the brain which creates dysfunction in the entire nervous system, as we begin to fail to adapt to environments appropriately. Essentially losing anti-fragility in the process due to having all types of misfiring by being thiamine deficient.

08:52 - Lonsdale characterized high-calorie malnutrition. This comes down to an up-regulation of macronutrients (refined fats, refined carbs, reined proteins) and down-regulation of micronutrients (vitamins, minerals, other nutrients). And as we consume too many refined macronutrients we deplete ourselves of micronutrients which leads to many of these disorders listed above. This excessive intake of glucose without adequate levels of co-factors that thiamine and other vitamins and minerals provide lead to sub-clinical deficits that leads to all sorts of a constellation of symptoms as illustrated throughout this video. Thiamine is particularly necessary for the appropriate metabolism of carbohydrates in particular, so those diets higher in carbs especially refined ones as you see with Dr. Ray Peat will require the higher need for thiamine and its cofactors, B-complex, magnesium, and potassium.

11:06 - Based on this concept previously spoken about here. The autonomic nervous system is in control of things like blood pressure, gut motility, body temperature, constriction and dilation of blood vessels, and those parts of the brain are also in control of appetite, and nutrient partitioning. As we can see many of the symptoms can be linked back to problems with the autonomic nervous system which is linked to thiamine deficits.

11:42 - Some primary risks are heavy alcohol use, whether binge or chronic use. High sugar consumption, white rice, refined carbs (bread, grains, etc.). Chronic digestive issues IBS-C or D, or A, diarrhea, constipation, etc. High activity stressors: athletics, workload, family breakup, or trauma. They tend to be Doers, so go-get-'em attitudes tend to lead to a crash due to thiamine depletion, this is partly due to ramping up the metabolism which requires a greater need for micronutrients like thiamine and its co-factors. Pharmaceutical Rx like diuretics or antibiotics (metronidazole) also induce deficits in thiamine which cause thiamine-wasting. Surgery/viral or bacterial infections low-grade or otherwise.

14:30 - After crashing from one of the above, generally you will see further carbohydrate metabolism and alcohol metabolism intolerances. Nervous system collapse, on fire, or chronic fatigue. A negative response to B vitamins & sometimes magnesium. Slight improvement on keto/carnivore diets but about 50% or so, this is because there is less requirement for thiamine on these diets. However, this doesn’t mean to stay on these diets as it doesn’t address the deficit but buys time. Neurological cardiovascular and/or digestive symptoms. Insomnia or not feeling rested after sleep. These all can drastically impact overall well-being and make it difficult to discover how to recover from this deep thiamine deficit.

17:10 - It is important to note that in opposition to the conventional way of viewing disease. Elliot Overton likes to look at it as a Spectrum of Severity. A conventional medical physician sees it as falling in the box of health or disease. But there is a large grey area in-between. Someone could be moderately healthy, but still, have moderate insufficiency, and they could develop a deficit of thiamine or other micronutrients as they gradually develop this deficit. But because they do not fit the diagnostic of a full-blown disease medicine dismisses them because they don’t fit diagnostic criteria. Which makes people ignore subtle sub-clinical deficits for long periods of time which can wreak havoc or lead to the straw the breaks the camel's back as it were.

18:15 - The Crash or Trigger is usually the straw that broke the Camel’s back. Metabolic stressors (trigger) are often from a chronic insufficiency minor or few symptoms and on the timeline, a Crash & Metabolic Shift can occur with multiple symptoms manifesting due to enzymatic down-regulation. It could be a loss of a loved one, car accident, surgery, excess food shifts, loss of a job, etc. So this acute event usually sends someone over the edge which shifts someone’s metabolism as they begin to develop symptoms they never had before, which seemingly randomly comes out of nowhere. And in the literature, it shows that actually people who are deficient in certain nutrients like thiamine, then the enzymes that use this nutrient you’ll see down-regulated which creates this enzymatic down-regulation which has to do with a sudden onset of symptoms out of nowhere that relied upon those enzymatic processes.

19:46 - So if we look at the full-blown deficiency of thiamine you find Berberi & Wernicke’s Encephalopathy. Which usually requires 100-1,000mg of thiamine per day independent of a healthy diet. Therapy may be necessary for 6-12 months to achieve full-blown remission of this disease. And carnivore and keto diets may simply reduce symptoms but ultimately you want to restore carbohydrate metabolism. And this is more evidence that diet alone is simply not enough. The RDA for thiamine is currently only about 1-1.5mg a day.

21:33 - Case Study 1. Male mid-twenties with a Medical history of {Neuropathy, Severe Constipation (once every 2-3 weeks), GERD & constant bloating, Severely underweight 116 pounds [53kg] at 6 feet tall and inability to gain weight, Unexplained low blood pressure, Autoimmune issues, Extreme fatigue, dizziness, breathlessness, and low blood pressure}. This client has had a very high and long consumption of white rice as a staple in his diet. And he has his Trigger being hospitalized 10 years prior. He tried multiple diets, even a strict PKD Carnivore diet for around 6 months, which helped with autoimmunity but not most of the other symptoms. He saw Elliot’s videos and got in contact with him. As he looked at it, he had this individual take TTFD (bioavailable thiamine titrating up to 150mg a day), high dose B complex, vitamin C, and magnesium malate.

24:28 - After an 8-week follow-up after one day, daily bowel movements. GERD, bloating, and indigestion almost disappeared after a few weeks. Gained 17.63 pounds (8kg) for the first time in nearly 10 years. Enjoys working out and is building muscle rapidly. Fatigue improved greatly, with no daytime sleeplessness. Overall immune symptomatic improvement in a short time frame. This all changed with just the suggestions of TTFD Thiamine with the co-factors listed above. Just another example of how some simple changes can drastically alter someone’s life.

25:39 - Case Study 2 Male mid-twenties with a Medical History of {Severe fatigue, and mental sluggishness, depression (feeling dissociated from the body), Chronically cold, and poor circulation, Chronic burping, and bloating, poor gastric motility (explaining that it felt like a rock was in his stomach) & constipation/loose stools, Terrible recovery from exercise, Previous neuropathy, palpitations (cardio abnormalities) and twitching.

27:07 - History continued: Long consumption of white rice/bodybuilder diet & alcohol during university. Antibiotics & infection trigger. Lost tolerance to carbs, coffee, and alcohol. Multiple variations of keto/carnivore for 18 months with some improvement, but still struggling.

27:54 - Lab work CBC + CMP Unremarkable. Organic acids (after a few weeks of B1 therapy). A slight elevation in lactate (related to low thiamine), 2-hydroxyisovaleric acid (BCKDH marker) [marker related to branch-chain amino acid metabolism]. Minor elevations in oxalate markers.

28:27 - Glycolytic Cycle Metabolites Lactic acid 22 High (acceptable reference range 0.74-19.0). Amino Acid Metabolites 2-hydroxyisovaleric acid 3.1 (acceptable reference range 0.41 or lower). Oxalate Metabolites Glycolic Acid 111 High (acceptable reference range 18-81).

28:42 - Therapy Worked up to 500mg TTFD Thiamine w/ Magnesium malate (he got worse initially, then got better, as this fluctuates due to increasing metabolic machinery to adapt to thiamine levels rising so titrate gently). With every subsequent increase in the dose, his symptoms got worse initially then better. Body heat increased like a furnace. Periods of feeling euphoric, better concentration, and energy. Bloating, burping, and digestive system made major improvements. Sometimes it can take 6-8 months to recover the machinery necessary to restore health from chronic thiamine deficiency.

30:02 - Case Study 3 Male early-twenties with a Medical History: Trigger - early stress at 10 years old, and he binged eat sugar as a coping mechanism leading to a bout of severe constipation. Gradually he developed the following symptoms. Burning mouth, feet, neuropathy. Severe SIBO, GERD, bloating, and slow motility + laryngopharyngeal reflux. Severe fatigue, poor temperature regulation, and no libido. Excessive salivation in the mouth, dizziness, and balance problems. Chronic pain, visual disturbances, etc.

32:00 - History continued. Tried almost every diet. Got worse with carnivore/keto & restrictive diets. Learned of thiamine deficiency, took benfotiamine before the consultation. Benfotiamine improved dizziness, and balance almost immediately. Saw Elliot’s videos and got in contact. Elliot doesn’t generally use benfotiamine versions, but the client noticed a difference with it at just one capsule a day.

32:44 - Therapy: Increase benfotiamine to 250mg 4 times a day. B complex, riboflavin & magnesium, etc. A gradual shift from benfotiamine to TTFD version of thiamine.

33:33 - Results after a few weeks. An increase in benfotiamine caused temporary improvement then worsening in symptoms. Shift to TTFD 300mg a day. Now able to say many different foods - meats, veggies, etc. within about two weeks on TTFD version of thiamine. Also able to exercise. Reflux completely disappeared, bloating/burping 70% improvement. Upper GI motility restored - bowel movement twice per day. Libido returned. Fatigue, LPR, and salivation still present. Early days. [My added suspicion might be sulfur metabolism issues with the benfotiamine version?].

34:21 - Case Study 4. Female mid-60’s with a Medical History: Air hunger and breathlessness with fatigue. Unexplained low blood pressure and high pulse rate. Central sleep apnea, and dizziness. History of metformin use (thiamine depletion). Elliot speaks to this case to illustrate how one single deficiency can manifest as several different symptoms.

35:53 - Therapy before coming to see Elliot: Self-prescribed 900mg benfotiamine and 600mg sulbutiamine, B complex and minerals, carnivore diet. She noticed little change in fatigue but a big improvement with air hunger and breathlessness. And her pulse rate balanced and her blood pressure balanced fast. When she doesn’t take that dose these symptoms return.

36:53 - Central sleep apnea is another one of those unknown symptoms of a thiamine deficit, related to oxygen deficiency in the brain.

37:04 - Thiamine Deficiency Disease, Dysautonomia, and High-Calorie Malnutrition by Derrick Lonsdale and Chandler Marrs. How to address this issue in more depth get this book!

37:48 - Next videos Clinical laboratory indications of thiamine deficiency. Are there lab tests available? Which labs might indicate a deficiency? Which is the best form of thiamine to take? What is the difference between the forms of thiamine? Which health conditions might benefit from which form?

This is lot to chew on. Thanks for the transcription. The great imitator. I think we're seeing some of that with this covid thing.

 

[Perry Staltic]

34:21 - Case Study 4. Female mid-60’s with a Medical History: Air hunger and breathlessness with fatigue. Unexplained low blood pressure and high pulse rate. Central sleep apnea, and dizziness. History of metformin use (thiamine depletion). Elliot speaks to this case to illustrate how one single deficiency can manifest as several different symptoms.

I can see someone like case study 4 showing up at a hospital terrified that she has covid, tests positive, or doesn't test positive and they hold her for observation where she gets a nosocomial infection (covid); then they eventually put her on a ventilator because of oxygen deficiency, which greatly reduces her life expectancy. The great imitator.

 

[Simatta]

This is lot to chew on. Thanks for the transcription. The great imitator. I think we're seeing some of that with this covid thing.

You're welcome. I agree I think it is an aspect in play.

I can see someone like case study 4 showing up at a hospital terrified that she has covid, tests positive, or doesn't test positive and they hold her for observation where she gets a nosocomial infection (covid); then they eventually put her on a ventilator because of oxygen deficiency, which greatly reduces her life expectancy. The great imitator.

Ha, I just learned how to reply to multiple things without having to do separate responses so as to not clog up these threads so inefficiently as I have been. I agree entirely. I think thiamine deficits are large much like B2/3/7/12, A/D3/K2/E, magnesium, potassium, calcium, copper, zinc, etc. And if not due to excess of the antagonist in some situations, simply a barrenness supply of said vitamin/mineral and its cofactors and how that impacts enzymatic processes and hormone metabolism, etc.

 

[Simatta]

I experienced this. Shoulder pain, arm pain, quite unpleasant. Also hair fall. Anything sulfuric seems to make my hair fall.

Missed this somehow. Yes, often riboflavin (B2) [around 10mg Riboflavin-5-phosphate], B6 [low-dose], B12 [methyl-forms but could require more nuance] with molybdenum [around 50mcg], selenium [around 50mcg] can address the sulfur metabolism issues up to a point to make a certain amount of sulfur tolerable for those having difficulty metabolizing these substances.

 

[Peater]

Missed this somehow. Yes, often riboflavin (B2) [around 10mg Riboflavin-5-phosphate], B6 [low-dose], B12 [methyl-forms but could require more nuance] with molybdenum [around 50mcg], selenium [around 50mcg] can address the sulfur metabolism issues up to a point to make a certain amount of sulfur tolerable for those having difficulty metabolizing these substances.

Great info thanks simatta

 

[Simatta]

Great info thanks simatta

You're welcome ^_^.

 

[Sulcuscentralis]

Agreed. You might like this video as well. Great point on potassium and I think magnesium as well as the obvious B complex.



I created Time-Stamps took like 2 hours but I felt it worthwhile.

00:39 - Why Elliot got interested in thiamine (author Dr. Derrick Lonsdale and the myth that thiamine deficiency disappeared)

02:00 - Thiamine deficiency first presented in Japan when refining rice to white rice because it was more aesthetically pleasing, which became a status symbol. Symptoms such as Beri Beri, peripheral nervous system disorder, Wernicke-korsakoff syndrome, psychosis, cardiac arrhythmias, gastrointestinal system via constipation, GERD, breathlessness, inability to concentrate, regulate emotions.

04:00 - When you refine foods you run into vitamin deficiencies even if physicians state thiamine deficiency is a thing of the past, Elliot has found this not to be the case. 04:43 - Alcoholic’s, anorexia begins to reseed usually on a lot of carbs and needs thiamine significantly.

05:16 - Early stage of thiamine deficiency doesn’t necessarily present as typical symptoms

05:27 - Dr. Derrick Lonsdale was a Cleveland Clinic Pediatrician who wrote a book co-authored with Chandler Marrs Thiamine Deficiency Disease, Dysautonomia, and High-Calorie Malnutrition

06:11 - Thiamine deficiency isn’t a thing of the past, Elliot’s perspective on going back to basics on to why we need thiamine. When you eat certain foods like fats, carbs, and proteins. We need enzymes, so say you consume sugar, and it is transported into the cells, the end product is usable energy called ATP. The cells need this to do things. For the cells to work you need co-factors like vitamins/minerals. Thiamine is a very important part of those enzymes to make utilization of energy from these foods particularly carbohydrates.

08:15 - Problem with refining the foods you take out the nutrients and minerals. So you get a pure energy food substrate, but without the co-factors to make use of this without taxing your reserves.

08:52 - Sugar cane has a vast amount of vitamins and minerals. And with thiamine being water-soluble you need to get them from somewhere, so you need a constant supply of them.

09:19 - Every time you have sugar or fats, you are using some of the thiamine you have. And ordinarily, when eating whole foods, you’ll be adding in thiamine when consuming sugar. The problem lies when you’re using refined foods you’re taxing thiamine. Therefore the problem you run into is carb metabolism issues cause the necessary co-factors aren’t any longer present with high-calorie vitamin/mineral deficits.

10:37 - Acetylcholine is one of the major neurotransmitters and needs thiamine to keep healthy levels. Because it helps with the synthesis of neurotransmitters. Thus nerve transmission and thinking requires thiamine.

10:52 - One of the symptoms of cognitive decline is from deficits of thiamine.

11:04 - Research suggests that thiamine is important for maintaining the health of the myelin sheath and the neurons themself.

11:21 - There is a part of the brain called the limbic system and it's part of the brain stem, (emotional brain) it is a primitive part that has a lot of control of the autonomic nervous system.

11:38 - The cells in that part of the brain are particularly sensitive to thiamine deficiency. And when there is no longer thiamine in that part of the brain it acts similar to a deficiency of oxygen. And we know what happens when there is a deficit of oxygen. The cells die and they no longer function. So this is similar to what happens to that part of the brain when thiamine is low.

12:03 - People can get more emotional, mood problems. Some symptoms of early stages of thiamine deficiency are depression, emotional instability, mood changes, bipolar, schizophrenia. And even though it impacts our emotions, it can impact our entire body. Because our nervous system is really in control of the vasculature, so it can control how many of the organs function especially the cardiovascular system. So when you look at early-stage thiamine deficiency, it can manifest in multiple different ways. One of the first symptoms is heart palpitations, but eventually, the heart can enlarge to try to make up what it perceives to be an oxygen deficit. Which can lead to heart failure.

13:12 - Even benign symptoms like Reynaurds which is the uncontrolled constriction and dilation of the blood vessels in response to different temperatures. But essentially when there is a thiamine deficiency, it means the nervous system can effectively no longer adapt to the environment. So temp regulation can be skewed.

13:36 - There is a condition called POTS postural orthostatic tachycardia syndrome, this typically involves the nervous system being unable to control the blood vessels which can result in all types of symptoms.

13:50 - This can also impact the gut, because we have to understand that the gut, in order for it to propel food from the stomach down the intestine it requires it to contract. So one of the aspects you’ll find is SIBO small intestinal bacterial overgrowth due to improper migrating motor complex which can go unrecognized.

14:15 - Pins and needles around the arms or neurological symptoms like this can be due to thiamine deficiency

14:52 - Thiamine’s function in energy metabolism. Energy metabolism occurs in every single cell. In order for all cells to do what they need to do they need enough energy. And when you look at various diseases all have mitochondrial dysfunction or defective energy production. This refers to cells no longer being able to make energy as well as it once did. And when we look at thiamine, it sits at the top of how a cell can make energy. Without it, energy production is mostly halted.

15:54 - What Derrick Lonsdale found was that people whom he treated, had skewed immune function and that’s because the immune system requires energy. So he saw in many of his client's poor immune function due to thiamine deficits.

16:16 - The integrity of tissue, say the bladder, the cells that line in the bladder being mucosa and in order for that mucosa to be healthy you need enough energy to produce healthy tissue. This being a more novel idea to medicine that restoring energy production restores tissue health. And how thiamine can improve so many conditions even that seem unrelated.

17:33 - A lot of research on thiamine being used for things like Chronic Fatigue. Which its base being mitochondrial dysfunction. Fibromyalgia being another. And the onset of CF and FB showed its face typically with the use of an antibiotic classified as a fluoroquinolone antibiotic. One of the aspects of this is fluoroquinolone depletes thiamine, and so researchers are using thiamine to successfully treat CF and Fibromyalgia. In one small study on Fibromyalgia, they found up to 80% of 3 people just supplementing thiamine in relief of malaise, subjective feeling of well-being, etc.

18:52 - Fluoroquinolone depletes thiamine in unknown ways but it has been documented. Elliot suspects oxalate components but it is very complex. And it may inhibit the absorption of thiamine. Ruptured tendons being an issue with fluoroquinolone, which likely has an issue with glycine, vitamin B6, vitamin C. It gets progressively complex.

20:45 - Trickle-down effect or downstream effect that can affect the metabolism of various B vitamins and collagen synthesis and energy metabolism. Some aspects being disruption of microbiome and oxalates.

21:09 - Need b vitamins to get nutrients in our tendons.

21:25 - Other medications such as oral contraceptives, metformin, (possibly NSAIDs), and many others reduce thiamine in the body.

22:09 - Most B vitamins are produced by the microbiome. But the majority comes from the diet.

22:31 - Another problem is absorption. One issue is tannins in tea, coffee, sulfites, hydrogen sulfite (imbalanced gut bacteria that produces hydrogen sulfite can degrade B vitamin in the gut so it doesn’t even get absorbed). Another issue is celiac, Crohn’s disease can potentially inhibit the absorption of thiamine. Also, genetic transporter issues such as mutations in genes would prevent proper absorption of thiamine more easily.

24:04 - Doses of thiamine. The type of thiamine named Thiamine HCL is of low bio-availability. When prescribed at therapeutic doses, not much is absorbed. But mega doses of around 300-600mg a day could have beneficial effects. Thiamine transporters on the cell membrane that help thiamine get into the cell. And this makes testing thiamine difficult. Because someone could have normal blood levels of thiamine, but it doesn’t mean it can get into the cell, and on top of that it doesn’t mean it can be utilized once in the cell. So to find thiamine that can get into the cell Benfotiamine can be used to readily get into the cell and treat diabetic neuropathy.

26:12 - Certain types of thiamine can get into the brain. TTFD Thiamine is a Lipo-Soluble that can get into the brain as shown in Japanese studies. These are lower doses, such as below 100mg, although higher doses could prove very helpful.

27:23 - When there is a chronic deficiency like thiamine. Because we have various machinery in our cells that use thiamine, and when we have low levels of the vitamin, the machinery [proteins, enzymes] are naturally going to be down-regulated to match the deficit. In that case, the enzymes may be down-regulated, but likewise, the transporters may also be down-regulated. So if there aren’t enough enzymes or transporters for thiamine, it won’t be used to a high efficacy. They basically found that you may need to do high dose thiamine to send a message to the body to encourage the body to adapt its machinery to match the requirement [proteins, enzymes, transporters] to heal the energy metabolism. Even POTs situations might need 3-5 months of treatment to see the benefit in those situations.

30:10 - POTs many symptoms can be eradicated permanently with thiamine if structural damage hadn’t occurred. Digestive symptoms, blood pressure issues, etc. Can be resolved with treatment.

31:17 - A chronic deficiency can go on for a very long time. And oftentimes you need a stressor to initiate warning signs of that chronic deficiency. It could be a vaccine, infection, UV light, life event, etc. Which can put a lot of stress on the system, which can illustrate the thiamine deficiency.

32:37 - Gardasil vaccine leads to POT’s in many situations and thiamine can treat this.

33:12 - Type 1 and Type 2 diabetics have shown 50-60% less thiamine in these groups in studies. What we see in the cell for these individuals impacts drastically how insulin works in these individuals. Even in non-diabetes thiamine deficits can show hypo or hyperglycemia. So blood sugar balance is very dependent on thiamine. And even in different eating behaviors like bulimia and anorexia, it can cause a voracious appetite or disenchantment with food, and with thiamine, you can treat both of these conditions. 34:35 - Thiamine is a very safe treatment. Upon administrating thiamine, we need magnesium. Sometimes when you administer thiamine you might see heart palpitations initially, if you take it with magnesium with a b complex these didn’t occur.

36:16 - Learning difficulties, autism seem to improve significantly with thiamine. As well as chronic vomiting, gastrointestinal issues, nausea, migraines, headaches all got better with thiamine administration. As well as cardiovascular issues typically respond favorably.

37:17 - Much of the heart's electrical activity is coordinated by the autonomic nervous system through the vagus nerve. And when there is low thiamine, it can really breakdown the body’s ability to regulate the stress system. One of the big symptoms is an over-active sympathetic nervous system [fight or flight]. Thiamine can really help intervene with these issues.

38:37 - Why do you think thiamine doesn’t get much attention? Elliot finds it odd there isn’t much publicity surrounding this substance. It is such a lone-wolf and so he hopes the book can encourage further research surrounding this safe effective treatment of so many conditions. Especially for those using sugar and refined foods as calorie sources.

39:45 - People with kidney failure, gastric bypass, anyone with anorexia, the elderly, and anyone who is young such as children all are very susceptible to thiamine deficits. The general population at large is likely suffering from some sub-clinical thiamine deficiency. As well with many people taking over-the-counter drugs, it can lead to deficits in thiamine. And especially gut dysbiosis (constipation or diarrhea). Mold toxicity is another major aspect that can deplete thiamine. He finds most people eating refined carbs especially are at risk of thiamine deficiency. And if you drink tea or coffee do so away from foods if you refuse to supplement. If you boil potatoes you lose the B vitamin.

Thank you for plugging this video! The guy in the video and Derrick Lonsdale saved my life.

 

[GenericName86]

Agreed. You might like this video as well. Great point on potassium and I think magnesium as well as the obvious B complex.



I created Time-Stamps took like 2 hours but I felt it worthwhile.

00:39 - Why Elliot got interested in thiamine (author Dr. Derrick Lonsdale and the myth that thiamine deficiency disappeared)

02:00 - Thiamine deficiency first presented in Japan when refining rice to white rice because it was more aesthetically pleasing, which became a status symbol. Symptoms such as Beri Beri, peripheral nervous system disorder, Wernicke-korsakoff syndrome, psychosis, cardiac arrhythmias, gastrointestinal system via constipation, GERD, breathlessness, inability to concentrate, regulate emotions.

04:00 - When you refine foods you run into vitamin deficiencies even if physicians state thiamine deficiency is a thing of the past, Elliot has found this not to be the case. 04:43 - Alcoholic’s, anorexia begins to reseed usually on a lot of carbs and needs thiamine significantly.

05:16 - Early stage of thiamine deficiency doesn’t necessarily present as typical symptoms

05:27 - Dr. Derrick Lonsdale was a Cleveland Clinic Pediatrician who wrote a book co-authored with Chandler Marrs Thiamine Deficiency Disease, Dysautonomia, and High-Calorie Malnutrition

06:11 - Thiamine deficiency isn’t a thing of the past, Elliot’s perspective on going back to basics on to why we need thiamine. When you eat certain foods like fats, carbs, and proteins. We need enzymes, so say you consume sugar, and it is transported into the cells, the end product is usable energy called ATP. The cells need this to do things. For the cells to work you need co-factors like vitamins/minerals. Thiamine is a very important part of those enzymes to make utilization of energy from these foods particularly carbohydrates.

08:15 - Problem with refining the foods you take out the nutrients and minerals. So you get a pure energy food substrate, but without the co-factors to make use of this without taxing your reserves.

08:52 - Sugar cane has a vast amount of vitamins and minerals. And with thiamine being water-soluble you need to get them from somewhere, so you need a constant supply of them.

09:19 - Every time you have sugar or fats, you are using some of the thiamine you have. And ordinarily, when eating whole foods, you’ll be adding in thiamine when consuming sugar. The problem lies when you’re using refined foods you’re taxing thiamine. Therefore the problem you run into is carb metabolism issues cause the necessary co-factors aren’t any longer present with high-calorie vitamin/mineral deficits.

10:37 - Acetylcholine is one of the major neurotransmitters and needs thiamine to keep healthy levels. Because it helps with the synthesis of neurotransmitters. Thus nerve transmission and thinking requires thiamine.

10:52 - One of the symptoms of cognitive decline is from deficits of thiamine.

11:04 - Research suggests that thiamine is important for maintaining the health of the myelin sheath and the neurons themself.

11:21 - There is a part of the brain called the limbic system and it's part of the brain stem, (emotional brain) it is a primitive part that has a lot of control of the autonomic nervous system.

11:38 - The cells in that part of the brain are particularly sensitive to thiamine deficiency. And when there is no longer thiamine in that part of the brain it acts similar to a deficiency of oxygen. And we know what happens when there is a deficit of oxygen. The cells die and they no longer function. So this is similar to what happens to that part of the brain when thiamine is low.

12:03 - People can get more emotional, mood problems. Some symptoms of early stages of thiamine deficiency are depression, emotional instability, mood changes, bipolar, schizophrenia. And even though it impacts our emotions, it can impact our entire body. Because our nervous system is really in control of the vasculature, so it can control how many of the organs function especially the cardiovascular system. So when you look at early-stage thiamine deficiency, it can manifest in multiple different ways. One of the first symptoms is heart palpitations, but eventually, the heart can enlarge to try to make up what it perceives to be an oxygen deficit. Which can lead to heart failure.

13:12 - Even benign symptoms like Reynaurds which is the uncontrolled constriction and dilation of the blood vessels in response to different temperatures. But essentially when there is a thiamine deficiency, it means the nervous system can effectively no longer adapt to the environment. So temp regulation can be skewed.

13:36 - There is a condition called POTS postural orthostatic tachycardia syndrome, this typically involves the nervous system being unable to control the blood vessels which can result in all types of symptoms.

13:50 - This can also impact the gut, because we have to understand that the gut, in order for it to propel food from the stomach down the intestine it requires it to contract. So one of the aspects you’ll find is SIBO small intestinal bacterial overgrowth due to improper migrating motor complex which can go unrecognized.

14:15 - Pins and needles around the arms or neurological symptoms like this can be due to thiamine deficiency

14:52 - Thiamine’s function in energy metabolism. Energy metabolism occurs in every single cell. In order for all cells to do what they need to do they need enough energy. And when you look at various diseases all have mitochondrial dysfunction or defective energy production. This refers to cells no longer being able to make energy as well as it once did. And when we look at thiamine, it sits at the top of how a cell can make energy. Without it, energy production is mostly halted.

15:54 - What Derrick Lonsdale found was that people whom he treated, had skewed immune function and that’s because the immune system requires energy. So he saw in many of his client's poor immune function due to thiamine deficits.

16:16 - The integrity of tissue, say the bladder, the cells that line in the bladder being mucosa and in order for that mucosa to be healthy you need enough energy to produce healthy tissue. This being a more novel idea to medicine that restoring energy production restores tissue health. And how thiamine can improve so many conditions even that seem unrelated.

17:33 - A lot of research on thiamine being used for things like Chronic Fatigue. Which its base being mitochondrial dysfunction. Fibromyalgia being another. And the onset of CF and FB showed its face typically with the use of an antibiotic classified as a fluoroquinolone antibiotic. One of the aspects of this is fluoroquinolone depletes thiamine, and so researchers are using thiamine to successfully treat CF and Fibromyalgia. In one small study on Fibromyalgia, they found up to 80% of 3 people just supplementing thiamine in relief of malaise, subjective feeling of well-being, etc.

18:52 - Fluoroquinolone depletes thiamine in unknown ways but it has been documented. Elliot suspects oxalate components but it is very complex. And it may inhibit the absorption of thiamine. Ruptured tendons being an issue with fluoroquinolone, which likely has an issue with glycine, vitamin B6, vitamin C. It gets progressively complex.

20:45 - Trickle-down effect or downstream effect that can affect the metabolism of various B vitamins and collagen synthesis and energy metabolism. Some aspects being disruption of microbiome and oxalates.

21:09 - Need b vitamins to get nutrients in our tendons.

21:25 - Other medications such as oral contraceptives, metformin, (possibly NSAIDs), and many others reduce thiamine in the body.

22:09 - Most B vitamins are produced by the microbiome. But the majority comes from the diet.

22:31 - Another problem is absorption. One issue is tannins in tea, coffee, sulfites, hydrogen sulfite (imbalanced gut bacteria that produces hydrogen sulfite can degrade B vitamin in the gut so it doesn’t even get absorbed). Another issue is celiac, Crohn’s disease can potentially inhibit the absorption of thiamine. Also, genetic transporter issues such as mutations in genes would prevent proper absorption of thiamine more easily.

24:04 - Doses of thiamine. The type of thiamine named Thiamine HCL is of low bio-availability. When prescribed at therapeutic doses, not much is absorbed. But mega doses of around 300-600mg a day could have beneficial effects. Thiamine transporters on the cell membrane that help thiamine get into the cell. And this makes testing thiamine difficult. Because someone could have normal blood levels of thiamine, but it doesn’t mean it can get into the cell, and on top of that it doesn’t mean it can be utilized once in the cell. So to find thiamine that can get into the cell Benfotiamine can be used to readily get into the cell and treat diabetic neuropathy.

26:12 - Certain types of thiamine can get into the brain. TTFD Thiamine is a Lipo-Soluble that can get into the brain as shown in Japanese studies. These are lower doses, such as below 100mg, although higher doses could prove very helpful.

27:23 - When there is a chronic deficiency like thiamine. Because we have various machinery in our cells that use thiamine, and when we have low levels of the vitamin, the machinery [proteins, enzymes] are naturally going to be down-regulated to match the deficit. In that case, the enzymes may be down-regulated, but likewise, the transporters may also be down-regulated. So if there aren’t enough enzymes or transporters for thiamine, it won’t be used to a high efficacy. They basically found that you may need to do high dose thiamine to send a message to the body to encourage the body to adapt its machinery to match the requirement [proteins, enzymes, transporters] to heal the energy metabolism. Even POTs situations might need 3-5 months of treatment to see the benefit in those situations.

30:10 - POTs many symptoms can be eradicated permanently with thiamine if structural damage hadn’t occurred. Digestive symptoms, blood pressure issues, etc. Can be resolved with treatment.

31:17 - A chronic deficiency can go on for a very long time. And oftentimes you need a stressor to initiate warning signs of that chronic deficiency. It could be a vaccine, infection, UV light, life event, etc. Which can put a lot of stress on the system, which can illustrate the thiamine deficiency.

32:37 - Gardasil vaccine leads to POT’s in many situations and thiamine can treat this.

33:12 - Type 1 and Type 2 diabetics have shown 50-60% less thiamine in these groups in studies. What we see in the cell for these individuals impacts drastically how insulin works in these individuals. Even in non-diabetes thiamine deficits can show hypo or hyperglycemia. So blood sugar balance is very dependent on thiamine. And even in different eating behaviors like bulimia and anorexia, it can cause a voracious appetite or disenchantment with food, and with thiamine, you can treat both of these conditions. 34:35 - Thiamine is a very safe treatment. Upon administrating thiamine, we need magnesium. Sometimes when you administer thiamine you might see heart palpitations initially, if you take it with magnesium with a b complex these didn’t occur.

36:16 - Learning difficulties, autism seem to improve significantly with thiamine. As well as chronic vomiting, gastrointestinal issues, nausea, migraines, headaches all got better with thiamine administration. As well as cardiovascular issues typically respond favorably.

37:17 - Much of the heart's electrical activity is coordinated by the autonomic nervous system through the vagus nerve. And when there is low thiamine, it can really breakdown the body’s ability to regulate the stress system. One of the big symptoms is an over-active sympathetic nervous system [fight or flight]. Thiamine can really help intervene with these issues.

38:37 - Why do you think thiamine doesn’t get much attention? Elliot finds it odd there isn’t much publicity surrounding this substance. It is such a lone-wolf and so he hopes the book can encourage further research surrounding this safe effective treatment of so many conditions. Especially for those using sugar and refined foods as calorie sources.

39:45 - People with kidney failure, gastric bypass, anyone with anorexia, the elderly, and anyone who is young such as children all are very susceptible to thiamine deficits. The general population at large is likely suffering from some sub-clinical thiamine deficiency. As well with many people taking over-the-counter drugs, it can lead to deficits in thiamine. And especially gut dysbiosis (constipation or diarrhea). Mold toxicity is another major aspect that can deplete thiamine. He finds most people eating refined carbs especially are at risk of thiamine deficiency. And if you drink tea or coffee do so away from foods if you refuse to supplement. If you boil potatoes you lose the B vitamin.

Thanks for posting this, I can't check out the video atm but will watch it a bit later for sure. Does he go over which type of thiamine is best to supplement with?

 

[ecstatichamster]

Agreed. You might like this video as well. Great point on potassium and I think magnesium as well as the obvious B complex.



I created Time-Stamps took like 2 hours but I felt it worthwhile.

00:39 - Why Elliot got interested in thiamine (author Dr. Derrick Lonsdale and the myth that thiamine deficiency disappeared)

02:00 - Thiamine deficiency first presented in Japan when refining rice to white rice because it was more aesthetically pleasing, which became a status symbol. Symptoms such as Beri Beri, peripheral nervous system disorder, Wernicke-korsakoff syndrome, psychosis, cardiac arrhythmias, gastrointestinal system via constipation, GERD, breathlessness, inability to concentrate, regulate emotions.

04:00 - When you refine foods you run into vitamin deficiencies even if physicians state thiamine deficiency is a thing of the past, Elliot has found this not to be the case. 04:43 - Alcoholic’s, anorexia begins to reseed usually on a lot of carbs and needs thiamine significantly.

05:16 - Early stage of thiamine deficiency doesn’t necessarily present as typical symptoms

05:27 - Dr. Derrick Lonsdale was a Cleveland Clinic Pediatrician who wrote a book co-authored with Chandler Marrs Thiamine Deficiency Disease, Dysautonomia, and High-Calorie Malnutrition

06:11 - Thiamine deficiency isn’t a thing of the past, Elliot’s perspective on going back to basics on to why we need thiamine. When you eat certain foods like fats, carbs, and proteins. We need enzymes, so say you consume sugar, and it is transported into the cells, the end product is usable energy called ATP. The cells need this to do things. For the cells to work you need co-factors like vitamins/minerals. Thiamine is a very important part of those enzymes to make utilization of energy from these foods particularly carbohydrates.

08:15 - Problem with refining the foods you take out the nutrients and minerals. So you get a pure energy food substrate, but without the co-factors to make use of this without taxing your reserves.

08:52 - Sugar cane has a vast amount of vitamins and minerals. And with thiamine being water-soluble you need to get them from somewhere, so you need a constant supply of them.

09:19 - Every time you have sugar or fats, you are using some of the thiamine you have. And ordinarily, when eating whole foods, you’ll be adding in thiamine when consuming sugar. The problem lies when you’re using refined foods you’re taxing thiamine. Therefore the problem you run into is carb metabolism issues cause the necessary co-factors aren’t any longer present with high-calorie vitamin/mineral deficits.

10:37 - Acetylcholine is one of the major neurotransmitters and needs thiamine to keep healthy levels. Because it helps with the synthesis of neurotransmitters. Thus nerve transmission and thinking requires thiamine.

10:52 - One of the symptoms of cognitive decline is from deficits of thiamine.

11:04 - Research suggests that thiamine is important for maintaining the health of the myelin sheath and the neurons themself.

11:21 - There is a part of the brain called the limbic system and it's part of the brain stem, (emotional brain) it is a primitive part that has a lot of control of the autonomic nervous system.

11:38 - The cells in that part of the brain are particularly sensitive to thiamine deficiency. And when there is no longer thiamine in that part of the brain it acts similar to a deficiency of oxygen. And we know what happens when there is a deficit of oxygen. The cells die and they no longer function. So this is similar to what happens to that part of the brain when thiamine is low.

12:03 - People can get more emotional, mood problems. Some symptoms of early stages of thiamine deficiency are depression, emotional instability, mood changes, bipolar, schizophrenia. And even though it impacts our emotions, it can impact our entire body. Because our nervous system is really in control of the vasculature, so it can control how many of the organs function especially the cardiovascular system. So when you look at early-stage thiamine deficiency, it can manifest in multiple different ways. One of the first symptoms is heart palpitations, but eventually, the heart can enlarge to try to make up what it perceives to be an oxygen deficit. Which can lead to heart failure.

13:12 - Even benign symptoms like Reynaurds which is the uncontrolled constriction and dilation of the blood vessels in response to different temperatures. But essentially when there is a thiamine deficiency, it means the nervous system can effectively no longer adapt to the environment. So temp regulation can be skewed.

13:36 - There is a condition called POTS postural orthostatic tachycardia syndrome, this typically involves the nervous system being unable to control the blood vessels which can result in all types of symptoms.

13:50 - This can also impact the gut, because we have to understand that the gut, in order for it to propel food from the stomach down the intestine it requires it to contract. So one of the aspects you’ll find is SIBO small intestinal bacterial overgrowth due to improper migrating motor complex which can go unrecognized.

14:15 - Pins and needles around the arms or neurological symptoms like this can be due to thiamine deficiency

14:52 - Thiamine’s function in energy metabolism. Energy metabolism occurs in every single cell. In order for all cells to do what they need to do they need enough energy. And when you look at various diseases all have mitochondrial dysfunction or defective energy production. This refers to cells no longer being able to make energy as well as it once did. And when we look at thiamine, it sits at the top of how a cell can make energy. Without it, energy production is mostly halted.

15:54 - What Derrick Lonsdale found was that people whom he treated, had skewed immune function and that’s because the immune system requires energy. So he saw in many of his client's poor immune function due to thiamine deficits.

16:16 - The integrity of tissue, say the bladder, the cells that line in the bladder being mucosa and in order for that mucosa to be healthy you need enough energy to produce healthy tissue. This being a more novel idea to medicine that restoring energy production restores tissue health. And how thiamine can improve so many conditions even that seem unrelated.

17:33 - A lot of research on thiamine being used for things like Chronic Fatigue. Which its base being mitochondrial dysfunction. Fibromyalgia being another. And the onset of CF and FB showed its face typically with the use of an antibiotic classified as a fluoroquinolone antibiotic. One of the aspects of this is fluoroquinolone depletes thiamine, and so researchers are using thiamine to successfully treat CF and Fibromyalgia. In one small study on Fibromyalgia, they found up to 80% of 3 people just supplementing thiamine in relief of malaise, subjective feeling of well-being, etc.

18:52 - Fluoroquinolone depletes thiamine in unknown ways but it has been documented. Elliot suspects oxalate components but it is very complex. And it may inhibit the absorption of thiamine. Ruptured tendons being an issue with fluoroquinolone, which likely has an issue with glycine, vitamin B6, vitamin C. It gets progressively complex.

20:45 - Trickle-down effect or downstream effect that can affect the metabolism of various B vitamins and collagen synthesis and energy metabolism. Some aspects being disruption of microbiome and oxalates.

21:09 - Need b vitamins to get nutrients in our tendons.

21:25 - Other medications such as oral contraceptives, metformin, (possibly NSAIDs), and many others reduce thiamine in the body.

22:09 - Most B vitamins are produced by the microbiome. But the majority comes from the diet.

22:31 - Another problem is absorption. One issue is tannins in tea, coffee, sulfites, hydrogen sulfite (imbalanced gut bacteria that produces hydrogen sulfite can degrade B vitamin in the gut so it doesn’t even get absorbed). Another issue is celiac, Crohn’s disease can potentially inhibit the absorption of thiamine. Also, genetic transporter issues such as mutations in genes would prevent proper absorption of thiamine more easily.

24:04 - Doses of thiamine. The type of thiamine named Thiamine HCL is of low bio-availability. When prescribed at therapeutic doses, not much is absorbed. But mega doses of around 300-600mg a day could have beneficial effects. Thiamine transporters on the cell membrane that help thiamine get into the cell. And this makes testing thiamine difficult. Because someone could have normal blood levels of thiamine, but it doesn’t mean it can get into the cell, and on top of that it doesn’t mean it can be utilized once in the cell. So to find thiamine that can get into the cell Benfotiamine can be used to readily get into the cell and treat diabetic neuropathy.

26:12 - Certain types of thiamine can get into the brain. TTFD Thiamine is a Lipo-Soluble that can get into the brain as shown in Japanese studies. These are lower doses, such as below 100mg, although higher doses could prove very helpful.

27:23 - When there is a chronic deficiency like thiamine. Because we have various machinery in our cells that use thiamine, and when we have low levels of the vitamin, the machinery [proteins, enzymes] are naturally going to be down-regulated to match the deficit. In that case, the enzymes may be down-regulated, but likewise, the transporters may also be down-regulated. So if there aren’t enough enzymes or transporters for thiamine, it won’t be used to a high efficacy. They basically found that you may need to do high dose thiamine to send a message to the body to encourage the body to adapt its machinery to match the requirement [proteins, enzymes, transporters] to heal the energy metabolism. Even POTs situations might need 3-5 months of treatment to see the benefit in those situations.

30:10 - POTs many symptoms can be eradicated permanently with thiamine if structural damage hadn’t occurred. Digestive symptoms, blood pressure issues, etc. Can be resolved with treatment.

31:17 - A chronic deficiency can go on for a very long time. And oftentimes you need a stressor to initiate warning signs of that chronic deficiency. It could be a vaccine, infection, UV light, life event, etc. Which can put a lot of stress on the system, which can illustrate the thiamine deficiency.

32:37 - Gardasil vaccine leads to POT’s in many situations and thiamine can treat this.

33:12 - Type 1 and Type 2 diabetics have shown 50-60% less thiamine in these groups in studies. What we see in the cell for these individuals impacts drastically how insulin works in these individuals. Even in non-diabetes thiamine deficits can show hypo or hyperglycemia. So blood sugar balance is very dependent on thiamine. And even in different eating behaviors like bulimia and anorexia, it can cause a voracious appetite or disenchantment with food, and with thiamine, you can treat both of these conditions. 34:35 - Thiamine is a very safe treatment. Upon administrating thiamine, we need magnesium. Sometimes when you administer thiamine you might see heart palpitations initially, if you take it with magnesium with a b complex these didn’t occur.

36:16 - Learning difficulties, autism seem to improve significantly with thiamine. As well as chronic vomiting, gastrointestinal issues, nausea, migraines, headaches all got better with thiamine administration. As well as cardiovascular issues typically respond favorably.

37:17 - Much of the heart's electrical activity is coordinated by the autonomic nervous system through the vagus nerve. And when there is low thiamine, it can really breakdown the body’s ability to regulate the stress system. One of the big symptoms is an over-active sympathetic nervous system [fight or flight]. Thiamine can really help intervene with these issues.

38:37 - Why do you think thiamine doesn’t get much attention? Elliot finds it odd there isn’t much publicity surrounding this substance. It is such a lone-wolf and so he hopes the book can encourage further research surrounding this safe effective treatment of so many conditions. Especially for those using sugar and refined foods as calorie sources.

39:45 - People with kidney failure, gastric bypass, anyone with anorexia, the elderly, and anyone who is young such as children all are very susceptible to thiamine deficits. The general population at large is likely suffering from some sub-clinical thiamine deficiency. As well with many people taking over-the-counter drugs, it can lead to deficits in thiamine. And especially gut dysbiosis (constipation or diarrhea). Mold toxicity is another major aspect that can deplete thiamine. He finds most people eating refined carbs especially are at risk of thiamine deficiency. And if you drink tea or coffee do so away from foods if you refuse to supplement. If you boil potatoes you lose the B vitamin.

thank you so much. This is great.

 

[mbachiu]

Is anyone here from Canada who has found a decent allithiamine brand? I’ve been searching & can only find benfothiamine (or the other two types).

 

[ilhanxx]

I start sulbutiamin program today, I hope it will be good option for my asthenia, procrastination and mood swing problems. Also I will make topical solution for hair. It has 0.0467 mg/mL water solubility properties.